ESPE2023 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (34 abstracts)
Relationship between birth body weight<10.th centile (sga) and insulin-like growth factor binding protein-3: relevance of birth chest circumference / birth body weight ratio independently of birth gestational age, insulin-like growth factor binding protein-1 and -2 in the not-life threatened newborn
Cesare Terzi 1,2 , Raffaele Virdis 1,2 , Cristiana Magnani 3 , Gabriele Tridenti 3 , Andrea Cerioli 4 , Marco Riani 4 , Lidia Garavelli 3 , Gian Luigi De Angelis 1,2 , Sergio Bernasconi 1,2 , Werner F. Blum 5 & Giacomo Banchini 3
1Dept of Medicine and Surgery, University of Parma, Parma, Italy. 2Mother-Child Dep.t, Azienda Ospedaliero-Univesritaria di Parma, Parma, Italy. 3Mother-Child Dep.t, S. Maria Nuova Hospital Reggio Emilia, Reggio Emilia, Italy. 4Dep.t of Economics, University of Parma, Parma, Italy. 5Center of Child and Adolescent Medicine, Justus-Liebig University Giessen, Giessen, Germany
Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Growth retarded fetuses gestated by hypoxic pregnant animals may present increments of blood serum Insulin-like Growth Factor Binding Protein(IB)1 (IB1) and IB2, but not of IB3. An evaluation of the relevance of human newborn(NWB) CC/BW ratio(i.e., CC through BW, CC/BWR) to relationships between BW<=10.th centile for GA(SGA) and IB3 was conducted by multiple linear regression(MLR). NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid-, catecholamine- or methylxantine-based treatments, life-threatening disease, diabetes mellitus(DM) or other endocrine diagnosis, malformation, and mother with DM were excluded. 78 included NWBs, all studied before covid-19 pandemic and from conception to study end near sea-level, had complete data for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), IB1, IB2 and IB3 radioimmunoassay(unit=uM/dl), and for 2) gender(SEX), GA(unit: complete week; extremes=28–42), GA<=36 present(PTB, n=46), CC(25th-75th centiles=27-32cm), BW(25th-75th centiles=1926-2942g), and SGA(n=20)(computations; male SEX(n=43), SGA; condition absent=0, condition present=1). SPSS-28 software was used to generate GA-unrelated CC/BWR standardized residuals(CC/BWRsr)(i.e., Linear regression procedure-Save pushbutton/ Standardized residual checkbox-Continue pushbutton/ regress CC/BWR on only GA). IB1, IB2 and IB3 averages were calculated at x-y-z time-points (i.e., (x+y+z)/3; resp. IB1M, IB2M and IB3M). IB3RM normal score according to Van der Waerden(IB3M-NS) was normally distributed. Spearman rank correlations between the following variable pairs are reported(Rho; significance): CC/BWRsr vs IB3M(-.304; P=.007), IB1M vs IB3M(-.251: P=.027), IB2M vs IB3M(-.257; P=.015). SGA partial correlation(pc) coefficient(pcc) with outcome IB3M-NS in MLR was significant 1) with SEX-GA-SGA-PNAx-IB1M-IB2M as predictors (SGA vs IB3M-NS; t=-3.526, P=.0007, pcc=-.386), but non-significant 2) with SEX-GA-SGA-CC/BWRsr-PNAx-IB1-IB2 as predictors(MLR R2,. 501 /. 568, always significant). CC/BWRsr could be involved in inverse relationships between SGA and IB3M-NS after controls including GA, IB1M and IB2M in not-life-threatened NWBs.
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