ESPE Abstracts

Objective of The Study: To study the characteristics of carbohydrate and lipid metabolism in obese children and adolescents depending on the age.

Materials and Methods: We examined 171 children and adolescents aged from 6 to 16. Among them, there were 100 children and adolescents with ECO and 71 healthy children and adolescents. ECO patients were divided into 2 groups: group 1 including children with ECO aged 6-<10 years old, group 2 with adolescents aged 10-<16 years old. All the children and adolescents were checked for lipids, carbohydrate metabolism, insulin resistance using HOMA-IR. RESULTS AND DISCUSSION: In children aged from 6 to 10 years old, the indicators of carbohydrate metabolism differed significantly from the control, while the level of activity in 2 hours (11.6%) and HbA1c (15.2%) in patients of the second group was higher. Impaired fasting glycemia (fasting ≥5.6<6.1 mmol/l; in 2 hours <7.8 mmol/l) caces were not identified in 1 (5.0%) 7 years old girl and 3 (3.8%) adolescents with ECO. Analysis of the lipid spectrum indicators showed that both in the 1st and 2nd groups were patients with total cholesterol ≥5.2 mmol / l (25.0% and 37.5%, respectively), TG ≥ 1.7 mmol /l (60.0% and 70.0%, respectively), LDL ≥3.5 mmol/l (30.0% and 23.8%, respectively) and HDL < 1.03 mmol/l (15.0% and 33.8%). In children under 10 years old, the level of total cholesterol and HDL did not differ significantly from the control. LDL in patients of this group was 2.4 times (P=0.0001), TG 1.8 times (P=0.0001) and AI 1.4 times (P=0.04) higher, than in the children of the control group. In the group of adolescents, the data of the lipid spectrum differed significantly from the control. So, the level of total cholesterol was increased by 34.2%, LDL by 76.4%, TG by 66.7% and AI by 42.1% compared to adolescents from the control group. HOMA-IR reference values for children (1.2) and adolescents (1.8) were calculated. HOMA-IR index ≥97 peppers (≥1.2 for children) was detected in 5 (29.4%) of 17 children. Cases of HOMA-IR≥97pp. (≥1.8 for adolescents) were registered in 47 (70.1%) of 67 adolescents.

Conclusions: 1. HOMA index > 97 percentile (>1.2 for children) was detected in 75% of the children of group 1) Cases with HOMA>97 percentile (>1.8 for adolescents) were registered in 70.1% of adolescents of 2nd group.