ESPE2023 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (34 abstracts)
Relationships between birth body weight<10.th centile (SGA) and insulin-like growth factor-ii / insulin-like growth factor binding protein-3 ratio in the not-life threatened newborn: relevance of birth chest circumference / birth body weight ratio and oxygen supplementation
Cesare Terzi 1,2 , Werner F. Blum 3 , Cristiana Magnani 4 , Gabriele Tridenti 4 , Andrea Cerioli 5 , Marco Riani 5 , Elena Chesi 4 , Gian Luigi De Angelis 1,2 , Sergio Bernasconi 1,2 , Raffaele Virdis 1,2 & Giacomo Banchini 4
1Dept of Medicine and Surgery, University of Parma, Parma, Italy. 2Mother-Child Dept, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. 3Center of Child and Adolescent Medicine, Justus-Liebig University Giessen, Giessen, Germany. 4Mother-Child Dept, S. Maria Nuova Hospital Reggio Emilia, Reggio Emilia, Italy. 5Dept of Economics, University of Parma, Parma, Italy
Direct relationships of estimated birth brain weight(BRW) to birth body weight (BW) ratios (BBR) and of BW<=10.th centile for GA(SGA) with blood serum Insulin-like Growth Factor-II(IG2) to blood serum Insulin-like Growth Factor Binding Protein-3 (IB3) ratios (IG2/IB3R), and inverse relations between BW-SDS and birth chest circumference(CC) / BW ratio (i.e., CC through BW; CC/BWR) have been detected by our group in the human newborn(NWB). We evaluated the possibility that CC/BWR could be involved in NWB BBR-IG2/IB3R relationships. NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid-, catecholamine- or methylxantine-based treatments, life-threatening disease, diabetes mellitus(DM) or other endocrine diagnosis, malformation, and mother with DM were excluded. 78 included NWBs, all studied before covid-19 pandemic and from conception to study end near sea-level, had complete data for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), %O2 in respiratory gases(FiO2; range, x=21-80, y=21-30, z=21-26) and IG2 and IB3 radioimmunoassay(unit=uM/dl), and for 2) gender (SEX), GA(unit:complete week; extremes=28–42), GA<=36 present(PTB, n=46), CC(25th-75th centiles=27-32cm), BW(unit=g; 25th-75th centiles=1926-2942g), and SGA(n=20)(computations; male SEX(n=43), SGA; condition absent=0, condition present=1). BRW (unit=g; 0.037 × head circumference (cm)2.57) and BBR(100 x (BRW/BW)) were calculated according to Lindley - McLennan. SPSS-28 software was used to generate GA-unrelated BBR and CC/BWR standardized residuals(resp. BBRsr and CC/BWRsr)(i.e., Linear regression procedure-Save pushbutton/ Standardized residual checkbox-Continue pushbutton/ regress either BBRsr or CC/BWR on only GA). IG2/IB3R at x-y-z time-points was averaged (i.e., (x+y+z)/3; IG2/IB3RM). IG2/IB3RM normal score according to Van der Waerden(IG2/IB3RM-NS) resulted normally distributed. Spearman rank correlations between the following variable pairs are reported(Rho; significance): BBRsr vs CC/BWRsr(.738; P<.000001), CC/BWR vs IG2/IB3RM(,564; P<.000001), CC/BWR vs FiO2x(.401, P=.0003), FiO2x vs IG2/IB3RM(.451, P<.00005). Partial correlation(pc) coefficient(pcc) of BBRsr pc with outcome IG2/IB3RM-NS in Multiple linear regression (MLR) was significant(t=4.287, P<.00005, pcc=.451) with SEX-GA-BBRsr -FiO2x-PNAx-FiO2x as predictors, but was non-significant with SEX-GA-BBRsr-CC/BWRsr-FiO2x-PNAx-FiO2x as predictors (MLR R2,. 332 /. 440, always significant). CC/BWRsr could be involved in direct relationships between BBRsr and IG2/IB3RM-NS independently of GA and FiO2x in not-life-threatened NWBs.
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