Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Poster Category 1

Pituitary, Neuroendocrinology and Puberty

hrp0097p1-142 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Stimulated copeptin based diagnosis of central diabetes insipidus in children and adolescents

Gippert Sebastian , Choukair Daniela , Brune Maik , Bettendorf Markus

Introduction: Diagnosis of central diabetes insipidus (CDI) remains challenging. Water deprivation test and hypertonic saline infusion, as established diagnostic tests, are mentally and physically demanding for patients. Copeptin response to arginine-stimulation and insulin tolerance test (ITT) has been shown to be a putative parameter in the diagnosis of CDI in adults, but data are lacking for children and adolescents.Methods:</...

hrp0097p1-143 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Comparison of the Test Accuracy of a Subcutaneous Gonadotropin-Releasing Hormone Agonist (Triptorelin Acetate) vs. Intravenous Gonadorelin in the Diagnosis of Central Precocious Puberty

Ahn Jungmin , Rim Jeong Hwal

Purpose: In the diagnosis of central precocious puberty (CPP), the gonadotropin-releasing hormone (GnRH) stimulation test using intravenously injected gonadorelin is the gold standard. However, gonadorelin is not always readily available. In this study, the diagnostic accuracy of a test based on the GnRH agonist triptorelin acetate (triptorelin) was compared to that of the classical gonadorelin-based test in the diagnosis of CPP in girls.<p class="abstext"...

hrp0097p1-144 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Idiopathic Central Precocious Puberty on the Rise: A Retrospective Study Before and During the COVID-19 Pandemic in a Portuguese Tertiary-Level Hospital

Miguel Resende Maria , Gomes Pereira Patrícia , Mendes Catarina , João Oliveira Maria , Borges Teresa , Freitas Joana

Background and Aims: In light of the recent evidence suggesting an increase in idiopathic central precocious puberty (ICPP) cases during the COVID-19 pandemic, this study aimed to assess the proportion of patients referred for precocious puberty (PP) and, within this group, the number of ICPP cases diagnosed before and during the pandemic. Additionally, we compared the demographic, anthropometric, and clinical characteristics of ICPP patients between the two g...

hrp0097p1-145 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Novel clinical and imaging tools to identify and grade hypothalamic disease in populations at risk

Cerbone Manuela , D'Arco Felice , A Spoudeas Helen , Clark Chris , T Dattani Mehul

Background: Hypothalamic dysfunction (HD) is life-threatening but precise diagnostic tools are lacking. Normal hypothalamic anatomy is difficult to delineate on MRI. Damage to the area is inferred from a visible lesion, but how widely it disturbs signalling connections or correlates with symptoms is unclear. Furthermore, in congenital/syndromic diseases the hypothalamus appears normal even in cases with clear HD. We aimed to develop novel clinical and radiolog...

hrp0097p1-146 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation of pubertal suppression in adolescents with gender dysphoria in different Tanner stadia

Becking-Malpasso Karlijn , Lahaije Fleur , Levels Willemien , Claahsen Hedi

Background: Gonadotropin-releasing hormone agonists (GnRHa) are common treatment in adolescents with gender dysphoria to prevent development of unwanted physical changes. However, the safe use of GnRHa is debated in the media and objective literature is sparse. Specifically, there is a lack of literature comparing between different Tanner stadia, since it is debatable whether GnRHa treatment is effective in adolescents who have almost gone through puberty (Tan...

hrp0097p1-147 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Quantification of overnight urinary gonadotropin excretion predicts imminent puberty in girls: a semi-longitudinal study

Demir And , Büyükgebiz Atilla , Aydin Adem , Hero Matti

Objectives: We explored the alternative of using overnight fold change in gonadotropin levels by comparing the last-night-voided and first-morning-voided urine concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as a conceptual analogy to the invasive gonadotropin-releasing hormone (GnRH) stimulation test setting.Methods: We investigated the nocturnal changes in the immunoreactivity levels o...

hrp0097p1-148 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Prevalence of brain alterations in boys with isolated central precocious puberty

Amodeo Mariaelisa , Deodati Annalisa , Pedicelli Stefania , Pampanini Valentina , Cianfarani Stefano

Introduction: Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in boys with central precocious puberty (CPP). In contrast to girls, in whom more than 90% of cases are idiopathic, it has been reported that 4 up to 75% of boys with CPP have pathological brain lesions.Aim: to evaluate the prevalence of brain lesions in males with isolated CPP and to identify potential clinical and bioc...

hrp0097p1-149 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation of new cutt-off points of the LHRH stimulation test in the diagnosis of central precocious puberty

Valls Llussà Aina , Murillo Vallés Marta , Martinez Couselo Silvia , Sol Ventura Paula

Introduction: Central precocious puberty (PPC) is defined by the appearance of sexual characters at a chronological age lower than -2.5DS of the average for the reference population. Diagnostic is clinical but the hormonal assessment is essential. Basal gonadotropin values are not enough for the diagnosis. Gonadotropin-releasing hormone (GnRH) stimulation tests evidence the activation of the hypothalamic-pituitary-gonadal axis, however there is controversy abo...

hrp0097p1-150 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Comparative of serum estradiol levels in girls with different types of precocious puberty by liquid chromatography tandem-mass spectrometry and chemiluminescence immunoassay method

Chen Linqi , Shen Xinyi

Objectives: To compare the levels of E2 in girls measured by LC-MS/MS and CLIA, and to evaluate the correlations between E2 levels and bone age, uterine length, and uterine volume.Methods: 133 newly diagnosed girls were selected. There were 80 girls in the ICPP group (44 in the Tanner II stage in the ICPP group, 36 in the Tanner III in the ICPP group), and 53 in the PT group, 40 healthy girls in the Tanner III gro...

hrp0097p1-151 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical profile of children with central precocious puberty in a single tertiary centre

Yen Wee Chun , Beng Hui Ng Nicholas , Wei Li Ho Cindy , Anjian Sng Andrew , Leiqiu Tay Vanerry , Seng Lee Yung , Yin Loke Kah , Yijuan Lim Yvonne

Introduction: Our study aimed to describe the clinical profile of children with central precocious puberty (CPP) presenting to a single tertiary centre, and to determine the factors that would lead patients and families to pursue treatment with gonadotrophin releasing hormone (GnRH) agonist as well as the predictors of a more favourable final adult height in this cohort.Methods: We conducted a retrospective medical chart...

hrp0097p1-152 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The awakening of the hypothalamic-pituitary-gonadal axis in the post-COVID era; the Greek experience.

Hatziagapiou Kyriaki , Anargyros Vasilakis Ioannis- , Binou Maria , Dolianiti Maria , C. Nicolaides Nicolas , Zoumakis Emmanouil , Papathanasiou Chryssanthi , Gkougkouli Eleni , Barouti Konstantina , Kanaka-Gantenbein Christina , D. Sakka Sophia

Background: Puberty onset results from the interplay between genetic and environmental factors. During COVID-19 pandemic, children experienced epidemic-related changes, such as stress, sedentary lifestyle, excessive use of electronic devices, all leading to weight gain.Objective: The aim of our study is to retrospectively evaluate the incidence of premature activation of the hypothalamic-pituitary-gonadal axis, as eviden...

hrp0097p1-153 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Precocious puberty: a new score to assist therapeutic management

Clemenceau Claire , Cuny Ariane , Feray Dagmara , Gayet Claire , Naccache Alexandre , Fraissinet François , Castanet Mireille

Context: Premature breast enlargement before the age of 8 in girls is caused by a broad spectrum from premature thelarche to central precocious puberty. Treatment with GnRH analogues aim to delay either early onset of menstruation with its psychological consequences and/or early epiphyseal fusion. The Indication of treatment is a challenge classically based on the result of the luteinizing hormone (LH)-releasing hormone (LHRH) stimulation test.<p class="ab...

hrp0097p1-154 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Central Precocious Puberty in Boys; Diagnosis, Treatment and Follow-up: A Nation-Wide Study

Odabasi Gunes Sevinc , Sakar Merve , Muratoglu Sahin Nursel , Karaguzel Gulay , Ayça Cimbek Emine , Darendeliler Feyza , Sarban Ezgi , Doger Esra , Onder Ganimet , Siklar Zeynep , Senyazar Gizem , Murat Aydin Aydin Hasan , Ozkan Behzat , Sangun Ozlem , Parlak Mesut , Akin Onur , Cansu Sahin Kadriye , Esen Ihsan , Kilinc Ugurlu Aylin , Seymen Gulcan , Bolu Semih , Sobu Elif , Ozalkak Servan , Demet Akbas Emine , Buyukyilmaz Gonul , Selver Eklioglu Beray , Ucar Ahmet , Kocaay Pinar , Tunc Selma , Bas Serpil , Dundar Ismail , Celebi Bitkin Eda , Torel Ergur Ayca , Bingol Aydin Dilek , Kirel Birgul , Ata Aysun , Atar Muge , Isakoca Mehmet , Hatun Aytac Kaplan Emel , Kontbay Tugba , Tepe Derya , Ercan Oya , Boyraz Mehmet , Akyurek Nesibe , Unal Edip , Ozcan Murat Nurhan , Bilge Koca Serkan , Kocabey Sutcu Zumrut , Çetinkaya Semra

Objective: The aim of this study was to evaluate demographic characteristics; clinical, laboratory, imaging features; and response to treatment of boys who were followed up and treated with the diagnosis of central precocious puberty (CPP) in Turkiye.Materials and Methods: The study was planned as a multicenter, retrospective study. Cases with a diagnosis of CPP, whose follow-up data were available were included. Patient...

hrp0097p1-155 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The long-term efficacy of triptorelin 3-month depot in girls with central precocious puberty

Hyun Park Kyu , Gwag Si-Hwa , Yoojin Chung Lindsey , Kang Eungu , Nam Hyo-Kyoung , Rhie Young-Jun , Lee Kee-Hyoung

Purpose: The 3-month gonadotropin-releasing hormone analogs (GnRHa) are expected to achieve better compliance in central precocious puberty (CPP) patients, but the 1-month depot remains the dominant choice for conventional treatment worldwide. Our study aimed to investigate the long-term efficacy of 3-month GnRHa for the treatment of CPP.Methods: In this retrospective study, 69 Korean girls diagnosed with CPP were includ...

hrp0097p1-156 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

A novel ROBO1 gene variant in a patient with pituitary stalk interruption and multiple congenital anomalies

Nioti Olga , Smyrnaki Pinelopi , Giatzakis Christoforos , Xekouki Paraskevi , Stratakis Constantine

Background: Pituitary stalk interruption syndrome is a rare disorder characterized by an absent or ectopic posterior pituitary, anterior pituitary hypoplasia and an interrupted pituitary stalk. In some cases, a variety of additional congenital defects may be present. A genetic cause is identified in only around 5% of all cases.Case presentation: A 13-year-old male presented to the pediatric endocrinology clinic because o...

hrp0097p1-157 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Girls born small for gestational age may have an earlier pubertal development comparing to girls born appropriate for gestational age

Nicolas Georges , Haddad Nicolas

Key words: girls, small for gestational age, thelarche, pubarche, menarche.Background: Small for gestational age (SGA) babies are more prone to have an earlier onset of pubertal development and menarche. We conducted a study comparing the first menarche of small for gestational age (SGA) to appropriate for gestational age (AGA) girl newborns.Objective: The objective of the study is...

hrp0097p1-158 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Outcome of Children with Neurofibromatosis in the West of Scotland.

Romagnoli Gea , Sepich Margherita , Ching Chen Suet , Ronghe Milind , Sastry Jairam , McIntosh Diana , O’Kane Roddy , Murphy Dermot , Guftar Shaikh M

Background: Neurofibromatosis 1 (NF1) is a clinically heterogeneous genetic condition caused by the mutation of the NF1 gene. Individuals with NF1 have an increased risk of developing tumours, both benign and malignant. The most characteristic are plexiform neurofibromas, occurring in almost all patients. Other manifestations include café-au-lait macules, ocular involvement, intertriginous freckling, and learning disabilities or behavioural problems. Th...

hrp0097p1-159 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Long-Term Effect of Gonadotropin-Releasing Hormone Analogue Therapy on Adult Height in Girls with Central Precocious Puberty Diagnosed before 4 Years of Age

Freire Analía , Gryngarten Mirta , Gabriela Ballerini María , Vieites Ana , Gabriela Ropelato María , Arcari Andrea

Background: Central precocious puberty (CPP) is uncommon before the age of 4 and treatment with GnRH analogues have shown unequivocal benefits. CPP during or near mini puberty entails differential clinical and biochemical features in the diagnosis and leads to longer treatment and follow-up. There are very limited studies with long-term outcomes about CPP girls exclusively < 4 years of age regarding growth, menarche, and adult height after GnRHa withdrawal....

hrp0097p1-160 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

COX deficiency: undescribed endocrinological features in three patients with SCO1 mutation

Barbato Alessandro , Gori Giulia , Sacchini Michele , Pochiero Francesca , Stagi Stefano

Background: Cytochrome C oxidase (COX) is the fourth component of the respiratory chain. This protein is located within the internal membrane of mitochondria. COX deficiency is an inherited mitochondrial disease associated with considerable genetic and clinical variability(1). In fact, four clinical subtypes of this condition have been identified, each one with several phenotypic and genetic variants. Mitochondrial complex IV deficiency nuclear type 4 is a rar...

hrp0097p1-161 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Quality of life domains changes in children with central precocious puberty

Raafat Shaimaa , Mowafy Ehsan , Abdelaal Esraa , Khalil Mona

Background: Precocious puberty is considered a stressful condition leading to psychosocial and behavioral problems in children. Many factors are involved in these changes such as early body changes which make them feeling strange and cause the sense of isolation from social groups. On the other hand, GnRHa treatment can affect psychological functioning of children with CPP through several pathways. There is controversy in the results of studies dealing with th...

hrp0097p1-162 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The Therapeutic Effect of Oral Desmopressin Lyophilisate Formulation in Children with Central Diabetes Insipidus

Anil Korkmaz Huseyin , Coskunol Fulya , Gonullu Ahmet , Ozkan Behzat

Background: Experience with oral desamino-D-arginine-8-vasopressin lyophilisate (OLD) for central diabetes insipidus (CDI) in children with CNS malformations is limited.Objective and hypotheses: We aimed to assess the efficacy of oral use of OLD in children with CDI.Methods: Clinical, laboratory, and imaging characteristics of twenty-five children with CDI treated with OLD were eva...

hrp0097p1-163 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Identification of novel NFKB2 mutation in a Korean boy presenting with muscle weakness

Kim Yoo-Mi , Kim Eun-Hee , Kim Minji , So Hyejin , Hyuk Lim Han

Introduction: Deficient anterior pituitary with variable immune deficiency (DAVID) syndrome is a rare condition characterized by symptomatic ACTH deficiency and primary hypogammaglobulinemia, caused by a heterozygous mutation in the NFKB2 gene (MIM#164012) on chromosome 10q24. We report the novel mutation of the NFKB2 gene in a Korean boy presenting with gait disturbance, calf pain, and abnormal thyroid function test.<s...

hrp0097p1-164 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Insight into Gut Microbiota of Normal Body Mass Index Girls with Idiopathic Precocious Puberty

Lin Yifan , Fu Dongxia , Yuan Shuxian , Wei Haiyan

Key words: precocious puberty; idiopathic central precocious puberty; premature thelarche; gut microbiota; HPG axisBackground: The incidence of precocious puberty and obesity has increased significantly after the COVID-19 epidemic, and the specific cause is not clear. There seems to be a causal relationship between obesity and idiopathic central precocious puberty. A few studies have shown that the changes of gut microbi...

hrp0097p1-165 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Pheochromocytoma and it's cardiovascular complications in children.

Rakhimzhanova Marzhan , Nurgaliyeva Assiya , Zhanatkyzy Aikerim

Intoduction: Pheochromocytoma is a neuroendocrine disease rarely encountered in childhood, and it’s complications are even less frequent among children. Catecholamine-induced cardiomyopathy (CICMPs) is a rare complication of pheochromocytoma with a reported incidence of 8–11 % of all patients. Symptoms are often accompanied by hypertension, which is most common among children. However, classical symptoms such as hypertension, paroxysmal headache, s...

hrp0097p1-341 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Correlation Analysis of Genotypes and Phenotypes of 91 young male paediatric patients with congenital hypogonadotropic hypogonadism

Fu Dongxia , Chen Jiajia , Wei Haiyan

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which is the master hormone regulating the reproductive axis. CHH can be divided into Kallmann syndrome (KS) with dysosmia and normosmic Congenital hypogonadotropic hypogonadism (nCHH) according to the presence or absence of an olfactory disorder.Methods:</...

hrp0097p1-342 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The relationship between the amount of ghrelin-positive cells in the stomach and the concentration of ghrelin and anti-ghrelin antibodies in the blood in short stature children, with additional analysis of the impact of H. pylori infection.

Kolasa-Kicińska Marzena , Stawerska Renata , Czkwianianc Elżbieta , Stawerski Wojciech , Stawerski Paweł , Foks Maciej , Lewiński Andrzej

Introduction: The growth process in children depends on GH/IGF-1. Ghrelin is stimulator of GH synthesis. Ghrelin also stimulates the orexigenic center peptides responsible for appetite. It is synthesized in the stomach, thus its secretion may be alter by gastrointestinal tract deseases. Recently, high titers of antibodies against some neuropeptides (including anti-ghrelin) have been found in indyviduals with certain microflora components, e.g. Helicobacter pyl...

hrp0097p1-343 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Facilitating Transition of Care Into Adulthood in Brain Cancer Survivors With Acquired Pediatric Growth Hormone Deficiency: Insights From an Advisory Board

Alter Craig , Boguszewski Margaret , Clemmons David , Dobri Georgiana , Geffner Mitchell , Kelepouris Nicky , Miller Bradley , Oh Rich , Shea Heidi , Yuen

Kevin

Childhood cancer survivors (CCS), particularly brain cancer survivors, are at risk of developing growth hormone deficiency (GHD) due to hypothalamic-pituitary damage from direct tumor mass effects or treatment. Optimization of testing, long-term treatment, and monitoring during care transition from pediatric to adult endocrinology providers remain challenging. A group of endocrinology experts convened to discuss these challenges, the risks and benefits of GH therapy in CCS wit...

hrp0097p1-344 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Neurobehavioural impairments in children with septo-optic dysplasia spectrum conditions: A systematic review

Mann Amy , Aghababaie Arameh , Kalitsi Jennifer , Martins Daniel , Paloyelis Yannis , R Kapoor Ritika

Background: Septo-optic dysplasia (SOD) is a rare condition diagnosed in children with two or more of the following: hypopituitarism, midline brain abnormalities, and optic nerve hypoplasia (ONH). Children with SOD experience varied visual impairment and endocrine dysfunction. Autistic-like behaviours have been reported, however the nature and prevalence of these neurobehavioural impairments remain to be fully understood. The present systematic review aimed to...

hrp0097p1-345 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

45 mg Subcutaneous Leuprolide Acetate Suppressed Unstimulated Luteinizing Hormone (LH) to Prepubertal Concentrations

Miller Bradley , Boldt-Houle Deborah , Daugherty Rhea , Atkinson Stuart

Background: There is evidence that unstimulated LH concentrations may be appropriate to monitor hormone suppression in children with central precocious puberty (CPP) during treatment with gonadotropin-releasing hormone agonists (GnRHa). Literature suggests that unstimulated LH concentrations <0.3 and >0.8 IU/L are prepubertal and clearly pubertal, respectively. We present secondary analyses of unstimulated LH suppression data from the pivotal trial of th...

hrp0097p1-346 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Does premature adrenarche affect adult height in girls?

Vuralli Dogus , Oguz Demir Osman , Celep Ismahan , Gonc Nazli , Ozon Alev

Background: Premature adrenarche (PA) is characterized by an advanced bone age (BA) relative to chronological age (CA); nevertheless, clinical importance of this is not entirely understood. Literature contains few data on the impact of increased BA on adult height (AH) in PA. Objective of this study is to assess AH in girls with PA, and factors influencing AH.Methods: Retrospective analysis was carried out on 477 girls w...

hrp0097p1-347 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Treatment of Children with Central Precocious Puberty (CPP) with Gonadotropin-Releasing Hormone agonist (GnRHa): Evaluation of The Effectiveness of Treatment and Recovery of Gonadal Function

Mohamed Duaa , Al Remeithi Sareea , Al Jneibi Sara , Elyazori Yara

Background: GnRHa is the treatment for CPP, it arrests puberty progression, slows bone age (BA) maturation, and increases pubertal height. In the last decades, the use of GnRHa has demonstrated its favorable effects on linear growth, although the net height gain and predictors of long-term outcomes remains debated. Concerns raised on thepotential negative effects of treatment on weight and reproductive function.Methods: ...

hrp0097p1-348 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical course and genetic analysis in patients with childhood-onset congenital combined pituitary hormone deficiency

Ha Lee Yoon , Young Kim Ka , Hye Lee Da , Jee Kim Min , Jeong Lee Yun , Ah Lee Young , Min Ko Jung , Ho Shin Choong

Background: Congenital combined pituitary hormone deficiency (CPHD) has various clinical presentations and can be caused by genetic defects related to pituitary development. We investigated the clinical features and genetic analysis in Korean patients with congenital CPHD.Method: Among 444 patients diagnosed with CPHD between 1994 and 2021 from Seoul National University Children’s Hospital, 43 patients with congeni...

hrp0097p1-349 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Compound heterozygous variants in ROBO1 gene cause CPHD and middle line defects

Sertedaki Amalia , Macropoulou Panagiota , Nikaina Eirini , Binou Maria , Farakla Ioanna , Siahanidou Tania , Kanaka-Gantenbein Christina

Abstract: Combined Pituitary Hormone Deficiency (CPHD) is characterized by growth hormone and at least one other pituitary hormone deficiency. It is of varying etiology, extent and severity and it usually occurs sporadically with only 10% of cases being familial. Although pathogenic variants in more than 30 genes expressed during the development of the head, hypothalamus and/or pituitary have been identified so far to cause genetic forms of CPHD, the aetiology...

hrp0097p1-350 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Onset of puberty and timing of menarche in Saudi schoolgirls: Riyadh Puberty Study II

Al Alwan Ibrahim , Babiker Amir , Alfaraidi Haifa , Al Juraibah Fahad , Al Dubayee Mohamed , Al Malki Samia , Tamimi Waleed

Objective: Puberty has a significant contribution to different psychosocial wellbeing aspects. Hence; it is crucial to understand the normal variations in onset and tempo of puberty in a specific population. In this study, we aimed to provide normative data on timing of onset of puberty and age of menarche in Saudi schoolgirls in RiyadhMethods: This is a cross-sectional field study (2011-2013) including Saudi schoolgirls...

hrp0097p1-351 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Kallmann syndrome as a manifestion of tubulinopathies - a boy with newly defined TUBB3 R262H syndrome.

Folga Barbara , Winczewska-Wiktor Anna , Smigiel Robert , Niedziela Marek , Kolesinska Zofia

Background: Microtubules, polar polymers of αβ-tubulin heterodimers, constitute dynamic cytoskeletal structures implicated in the regulation of axonal activity along with neuronal proliferation and migration. Tubulinopathies, caused by pathogenic variants in genes encoding different isotypes of tubulin, lead to a wide and overlapping range of nervous system malformations and neurodevelopmental disorders. Namely, heterozygous missense and nonsense mu...

hrp0097p1-352 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The incidence of central precocious puberty in Korea between 2012 and 2020, population-based study.

Chung InHyuk

Purpose: A decline in the age of pubertal onset and increases in the prevalence of central precocious puberty (CPP) have recently been widely reported throughout the world. Based on national population data, this study was conducted to analyze Korea's CPP incidence rate.Methods: Between 2012 and 2020, data from the Korean national health insurance service for girls aged 8 years and younger and boys aged 9 years and ...

hrp0097p1-353 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical features of hyperprolactinemia in children and adolescents

Sang Lee Hae , Suk Shim Young , Sub Lim Jung , Soon Hwang Jin

Background/Purpose: Hyperprolactinemia is a rare endocrine disorder in childhood and there are limited etiological, clinical, and demographic data. The purpose of this study was to evaluate the clinical features and course of hyperprolactinemia in childhood and adolescents and to help diagnose and plan the management.Methods: In this single-center retrospective study included 21 patients with hyperprolactinemia from Ajou...

hrp0097p1-354 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The effect of leuprolide acetate 11.25mg 3-month formulation in children with central precocious puberty: A systematic review and meta-analysis

Wu Wei , Huang Ke , Dong Guanping , Fu Junfen

Background: Central precocious puberty (CPP) results from the premature pubertal activation of the hypothalamic-pituitary-gonadal axis before eight years for girls or nine years for boys. A systematic review and meta-analysis was conducted to evaluate the long-term efficacy and safety of leuprolide acetate (LA) 11.25mg 3-month formulation in children with CPP.Methods: A systematic search in PubMed and Embase was conducte...

hrp0097p1-355 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Effects of probiotic supplementation during childhood on the gut microbiota when puberty onset in lactating female mice

Yuan Xin , Chen Ruimin

Background: The relationship between probiotic supplementation and puberty onset has not been explored.Objective: To investigate the effects of probiotics oral intake during childhood on the gut microbiota when puberty onset in lactating female mice.Method: Feeding female mice with probiotic suspension of Bifidobacterium longum, Lactobacillus bulgaricus and Streptococcus thermophil...

hrp0097p1-356 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Acquired Hypothalamic dysfunction in childhood: “What do patients need?“ – an Endo-ERN survey

van Roessel I.M.A.A. , de Graaf J.P. , Biermasz N.R. , Charmandari E. , van Santen H.M.

Objective: Hypothalamic dysfunction is a rare condition and can be encountered in patients who have been diagnosed or treated for a suprasellar brain tumor. Due to its rarity, signs and symptoms of hypothalamic dysfunction may be difficult to recognize, leading to delayed diagnosis of the suprasellar brain tumor or to difficulties in finding the health care expertise for hypothalamic dysfunction after tumor treatment. To improve care and outcome of patients wi...

hrp0097p1-357 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation of the pituitary gland in patients with Fanconi Anemia

Corredor Andrés Beatriz , Solis Muñiz Inés , Zubicaray Josune , Martín Rivada Álvaro , Barrios Sabador Vicente , Sevilla Julián , Argente Jesús

Introduction: Fanconi anemia (FA) is a genomic instability syndrome associated with congenital abnormalities. Structural anomalies of the central nervous system (CNS), particularly a small pituitary gland, have been published in a few case series. This has been thought to be the cause of the short stature (SS) observed in FA.Methods: A cross-sectional exploratory study was carried out in pediatric patients at the FA Span...

hrp0097p1-358 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Do gonadotropin releasing hormone analogues increase the total body fat mass and body mass index in girls with idiopathic central precocious puberty?

Donbaloğlu Zeynep , Singin Berna , Barsal Cetiner Ebru , Aydin Behram Bilge , Bedel Aynur , Tuhan Hale , Parlak Mesut

Aim: Gonadotropin-releasing hormone analogues (GnRHa) are widely used in the treatment of idiopathic central precocious puberty (ICPP) cases due to premature maturation of the hypothalamus-pituitary-gonad axis. The effect of GnRHa therapy on body weight and fat distribution is controversial in the literature. We aimed to examine the anthropometric measurements and body composition analysis of the girls with ICPP and to investigate the effect of related factors...

hrp0097p1-359 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

An Evaluation of coping strategies in girls diagnosed of central precocious puberty before and after the COVID-19 lockdown, and in their mothers: preliminary study.

E Street Maria , Rollo Dolores , Rossi Maurizio , Sartori Chiara , Petraroli Maddalena , Pilloni Simone , Francavilla Roberta , Lattanzi Claudia , Miglioli Irene , Iughetti Lorenzo , Stagi Stefano

During the COVID-19 pandemic, a significant increase in Central Precocious Puberty(CPP) has been observed worldwide. The reasons for this phenomenon are yet unclear. In order to evaluate if fear, stress and coping strategies used by children and parents when dealing with negative emotional situations and health issues might have acted as triggers for this phenomenon, we administered specific questionnaires to girls who had a diagnosis of CPP before and after the COVID-19 relat...

hrp0097p1-360 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Management of central diabetes insipidus in disabled children with diluted oral desmopressin lyophilisate formulation administered through nasogastric tube

Anıl Korkmaz Hüseyin , Bhushan Arya Ved , Gönüllü Ahmet , Coşkunol Fulya , Özkan Behzat

Background: Experience with nasogastric administration of oral DDAVP [desamino-D-arginine-8-vasopressin] lyophilisate (ODL) for central diabetes insipidus (CDI) in disabled children with swallowing coordination difficulties is limited.Objective: We aimed to assess the safety and efficacy of nasogastric use of ODL in disabled children with CDI.Methods: Clinical, laboratory and neuro...

hrp0097p1-361 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

First interim analysis of the value of First Morning Voided(FMV)Urinary GnRH for the Diagnosis in China CPP Patients

Ye Feng , Luo Xiaoping , Dong Guoqing , Chen Ruimin , Dong Zhiya , Lu Wenli , Luo Feihong , Gong Chunxiu , Wei Liya , Yang Yu , Zhu Min , Ma Huamei , Chen Qiuli , Cheng Xinran , Gou Peng

Background: The gold standard for CPP diagnosis is gonadotropin releasing hormone stimulation test (GnRHST). However, this test is expensive, invasive and inconvenient for screening. Some recent studies have demonstrated that the FMV urinary luteinizing hormone (U-LH) has a strong correlation with LH peak value and serum basal LH, and a high consistency with Tanner staging results, but due to the lack of large-sample, multicenter clinical research data, a form...

hrp0097p1-362 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Case Report: rare case of genetic neurohypophyseal diabetes insipidus associated with congenital hypopituitarism: when the fluid deprivation test does not make the diagnosis

Ferri Chiara , Palmoni Monica , Finamore Martina , Mascaro Rossella , Polenzani Ilaria , Rizzi Alessia , Magnacavallo Annalia , Meroni Silvia , Bucolo Carmen , Barera Graziano , Pozzobon Gabriella

Six-year-old female, diagnosed with GH deficiency at another Center (H: -3.13SDS; H peak with clonidine 5.7ng/mL, with insulin 1.2ng/mL). Brain MRI at diagnosis: small pituitary gland, ectopic neurohypophysis, normal stalk, right internal carotid artery aplasia. At 10 years onset of polyuria-polydipsia syndrome (PPS) (4L/day–154ml/kg/die); mood disorders and ADHD diagnosis were also reported. A fluid deprivation test was performed, lasting 22 hours (pre: S-Osm 275mOsm/L,...

hrp0097p1-363 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Xanthomatous hypophysitis: A rare cause of paediatric hypopituitarism

Bendor-Samuel Owen , Statchard Rebecca , Daskas Nikolaos

Primary Xanthomatous Hypophysitis (XH) is the rarest histological subtype of hypophysitis. Here we describe the case of a young 9-year-old girl diagnosed with this condition. The patient presented with a four-month history of an intermittent temporal-frontal headache that became gradually worse and constant for three days prior to admission. She did not have clinical signs or symptoms suggestive of increased intracranial pressure but had mild ataxia. On admission she was febri...

hrp0097p1-364 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Transient diencephalic syndrome as a result of hypothalamic compression in a paediatric case of neurofibromatosis Type 1 (NF1).

Sepich Margherita , Romagnoli Gea , Ching Chen Suet , McIntosh Diana , O’Kane Roddy , Murphy Dermot , Guftar Shaikh M

Introduction: Diencephalic syndrome (DS) is a rare condition characterised by weight loss despite adequate calorie intake in association with other signs and symptoms such as hyperalertness, hyperactivity, visual field defects, nystagmus and vomiting. DS occurs in the presence of hypothalamic lesions, but its exact mechanism remains unclear. The diagnosis is often delayed due to the absence of specific clinical and biochemical features.<...

hrp0097p1-540 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Central precocious puberty in boys: clinical decision-making and secular trend

Huttunen Heta , Kärkinen Juho , Varimo Tero , J. Miettinen Päivi , Raivio Taneli , Hero Matti

Objective Recent studies suggest that boys are undergoing puberty at a younger age. Further, the number of idiopathic male central precocious puberty (CPP) cases are increasing over time. Only a few studies have evaluated the etiological factors in boys with CPP. We describe the etiology of CPP. Further, we define key auxological and clinical cues indicative of organic CPP (OCPP) and characterize the incidence of CPP.Methods&#x20...

hrp0097p1-541 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Prediction of Adult Height Based on Automated Bone Age Estimation in Early Puberty: A Single-Center Prospective Study

Huseyin Yigit Murat , Yesiltepe Mutlu Gul , Eviz Elif , Hatun Sukru

Introduction: In cases of precocious puberty, an important factor in making treatment decisions is when adult height estimates based on bone age (BA) determination are behind midparental height. In Turkey, clinicians often use the Greulich Pyle (GP) atlas to determine BA, which can lead to significant differences between assessors. The aim of this study was to compare estimated adult height (EAH) calculations based on BA determined by the automated BoneXpert m...

hrp0097p1-542 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Comparation between syndromic and non-syndromic central precocious puberty: a 10-year experience

Assirelli Valentina , Ortolano Rita , Baronio Federico , Di Natale Valeria , Cantarelli Erika , Bernardini Luca , Cassio Alessandra

Introduction: Central Precocious Puberty (CPP) has recently been described in patients with isolated or syndromic neurodevelopmental disorders, with greater attention from the scientific community. We carried out this study to compare the main aspects of non-isolated and isolated forms of CPP.Methods: We conducted a retrospective monocentric study, collecting all treated cases of CPP from 1st January 2013 to 31 December ...

hrp0097p1-543 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Phenotype and genotype in patients with growth hormone difenciency and pituitary morfology abnormality

Aguilar-Riera Cristina , González-Llorens Núria , Mogas Eduard , Campos Ariadna , Fàbregas Anna , Fernández Paula , Vázquez Elida , Yeste Diego , Clemente María

Introduction: Congenital hypopituitarism is a heterogeneous disorder with isolated hormone deficiency(IPHD) or combined(CPHD). Main risk factors for CPHD include H-P abnormalities such agenesis corpus callosum(ACC), anterior pituitary hypoplasia(APH), ectopic posterior pituitary(EPP), pituitary stalk interruption(PSI), septo-optic dysplasia(SOD), and holoprosencephaly(HPE).Patients and Methods: Prospective and longitudin...

hrp0097p1-544 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical and laboratory characteristics of arginine vasopressin resistance and high carrier frequency of a novel homozygous variant p.R113C in the AQP2 gene among Buryats

Makretskaya Nina , Nanzanova Ulyana , Hamaganova Irina , Eremina Elena , Filatova Alexandra , Skoblov Mikhail , Tiulpakov Anatoly

Background: Congenital nephrogenic diabetes insipidus (arginine vasopressin resistance) is a rare inherited disorder characterized by insensitivity of the kidney to the antidiuretic effect of vasopressin. About 90% cases nephrogenic diabetes insipidus is an X-linked recessive disorder caused by variants in the AVP V2 receptor gene (AVPR2). In the remaining cases (10%) the disease is autosomal recessive or dominant and, for these patients, variants in ...

hrp0097p1-545 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Challenges in Diagnosing and Managing Paediatric Metastatic Paraganglioma: A Case Report

Baioumi Alaa , Jayne Farndon Sarah , Crowne Elizabeth

Background: Paragangliomas are rare tumours that originate from neural crest cells. Diagnosing and managing patients with paragangliomas pose several challenges.Objective: We investigated whether MECP2 defects are associated with an idiopathic CPP phenotype with or without mild neurodevelopmental abnormalities.Clinical presentation: A 14-year-old female presented with cons...

hrp0097p1-546 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

SEMA3A gene variant may cause situs inversus, incomplete cleft palate, and congenital pituitary hormone deficiency

Eren Erdal , Tezcan Unlu Havva , Denkboy Ongen Yasemin , Cecener Gulsah

Introduction: Congenital multiple pituitary hormone deficiency (CMPHD) is a clinical condition that manifests in the early years of life. In most cases, pituitary stalk interruption syndrome (PSIS) can be detected by MR imaging. The current study presents a case with a novel candidate pathogenic gene Semaphorin 3A (SEMA3A) in CMPHD by whole-exome sequencing (WES).Materials and Methods: Genomic DNA was extracted from the ...

hrp0097p1-547 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation of Electrocardiographic Changes in Girls Receiving Gonadotropin-Releasing Hormone Analogs for Central Precocious Puberty

Er Eren , Ata Aysun , Orgun Ali

Background and Aim: Gonadotropin-releasing hormone analogs (GnRHa’s) are the standard medical treatment for precocious puberty. Studies on their side effects in adults have shown that these drugs can cause changes in electrocardiography (ECG) along with some cardiovascular effects; however, the number of studies on children is limited. This study aims to investigate the effect of these drugs on ECG parameters in children diagnosed with central precocious puber...

hrp0097p1-548 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Evaluation Of Long-term Height and Pubertal Outcome Of Boys Presented With Delayed Puberty Due To Constitutional Delay In Growth And Puberty And Isolated Hypogonadotropic Hypogonadism.

Doğan Özge , Vurallı Doğuş , Demirbilek Hüseyin

Background and objective: Delayed puberty is defined as a lack of the physical signs of puberty in boys by 14 years or beyond the reference age of population standards. This study aims to evaluate the pubertal development and final height (FH) outcome in patients presented with delayed puberty due to hypogonadotropic hypogonadism (HH) and constitutional delay in growth and puberty (CDGP).Design and participants: The hosp...

hrp0097p1-549 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Single nucleotide polymorphisms (SNPs) of the LIN28B gene and age at menarche in a sample of Greek girls

Tsinopoulou Vasiliki-Rengina , P. Kotanidou Eleni , Bacopoulou Flora , Fidani Liana , Gerou Spyridon , Galli-Tsinopoulou Assimina , Christoforidis Athanasios

Objectives: Menarche is defined as the first menstrual bleeding in females, and the age of onset varies and depends on a complex interaction between genetic and environmental factors. The LIN28B gene single nucleotide polymorphisms (SNPs) rs314276, rs7759938 and rs314280 appear to be associated with cases of premature and early menarche. International databases report that the presence of a G allele of rs314280SNP shifts menarche 1.2 months earlier, a C allele...

hrp0097p1-550 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The endocrine phenotype of SWI/SNF-associated Coffin-Siris syndrome includes pituitary endocrinopathies, pituitary hypoplasia, and septo-optic dysplasia

M McGlacken-Byrne1 Sinead , Wakeling Emma , Gaston-Massuet Carles , Peters Catherine , Dattani Mehul

Introduction: Coffin-Siris Syndrome (CSS) is a rare multisystem genetic disorder which arises from genetic abnormalities within genes encoding for the SWI/SNF complex (ARID1A, ARID1B, DPF2, SMARCA4, SMARCB1, SMARCA2, SMARCE1). Endocrinopathies have been associated with CSS, including idiopathic short stature, hyperinsulinism, obesity, growth hormone deficiency, and cryptorchidism. Here, we describe the endocrine features of a series of children with S...

hrp0097p1-551 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Alteration of sex steroid levels in boys with pubertal gynecomastia

Todorova Zdravka

Introduction: Pubertal gynecomastia (PG), the benign enlargement of breast in adolescents, is a condition whose etiology has not been fully elucidated. Its peak incidence is at mid puberty and decreases thereafter. In many cases breast undergoes full or almost complete regression with advancement of pubertal development, but in others it persists into adulthood. There are still controversies on the precise hormonal imbalance that leads in some adolescents only...

hrp0097p1-552 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

What girls know about puberty ?

Marzouk Asma , Siliti saida , Laajili Mariem , Kefi Ahlem , Thebti Rahma , Mzoughi oumaima , Ben Hssine sarra , Friha Farida , Bouaziz Asma

Introduction: Puberty is a very sensitive period in the life of every adolescent. Having enough knowledge about this physiological phenomenon would allow them to better understand the morphological and psychological changes and to better accept themselves. And therefore, to know how to distinguish between what is pathological and what is normal. This awareness is crucial to diagnose pubertal pathology in time. Hence the important role of school medicine in ens...

hrp0097p1-553 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

A 12-month, open-label, single-arm, phase 3 trial of the efficacy and safety of triptorelin 3-month formulation in Chinese children with central precocious puberty (CPP)

Luo Xiaoping , Zhang Cai , Yang Yu , Xu Xu , Cheng Xinran , Wei Haiyan , Wang Lanying , Huang Frank , Cabri Patrick

Background: CPP is commonly treated with triptorelin, a gonadotropin-releasing hormone (GnRH) analogue. It is available as 1-month and 3-month prolonged-release (PR) formulations, but only the former is approved for CPP in China. Overseas studies have proved the efficacy and safety of triptorelin 3-month PR formulation; this study evaluated efficacy and safety in Chinese children with CPP.Methods: In this 12-month, open-...

hrp0097p1-554 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The Evaluation of Cranial Magnetic Resonance Images of Rapidly Progressive Early Puberty Cases

Kilinç Uğurlu Aylin , Özdem&idot;r Gökçe Ayse , Çakir Gündoğan Seçil , Seçil EkşİOğlu Ayşe , Boyraz

Mehmet

Purpose: We aimed to determine the frequency and distribution of intracranial pathologies in patients over 8 years of age by evaluating MRI images of patients diagnosed with early puberty-rapidly progressive.Materials and Methods: The study comprised 118 female patients diagnosed with precocious puberty (PP) and rapidly progressive early puberty (RPEP). The onset of puberty in girls before the age of 8 years is defined a...

hrp0097p1-555 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Genetic bases of familial central precocious puberty

Khabibullina Dina , Kolodkina Anna , Bezlepkina Olga , Peterkova Valentina

Background: Nowadays, single nucleotide polymorphisms in genes KISS1, KISS1R, MKRN3, DLK1 have been described as the leading cause of precocious hypothalamic-pituitary axis activation in children. Genetic testing in patients with hereditary forms of precocious puberty (PP) can expand our knowledge in underlying molecular mechanisms of the disease. The diagnosis of genetic bases is necessary for genetic counselling.Aim: T...

hrp0097p1-556 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Oxytocin Improved Neurobehavioural Dysfunction in an Adolescent Post-Craniopharyngioma Surgery: A case report

Mann Amy , Fox Krystal , Kalitsi Jennifer , R Buchanan Charles , Bhushan Arya Ved , Paloyelis Yannis , R Kapoor Ritika

Background: Craniopharyngioma is a benign tumour that develops in the sellar and surrounding parasellar regions, including the hypothalamus and the pituitary gland responsible for the production and regulation of neuropeptides. Oxytocin is a hypothalamic neuropeptide that has been identified as a key modulator of appetite drive and social cognition. Here, we present a case of parent-observed improvements in neurobehavioural dysfunction following administration...

hrp0097p1-557 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Novel LHX4 rare variant in three patients affected by congenital hypopituitarism, presenting a further co-occurrent desease causing variants in GLI2 and IGF1R

Aiello Francesca , Luongo Caterina , Pascarella Filomena , Rosaria Licenziati Maria , Laura Torella Anna , Del Vecchio Blanco Francesca , miraglia del giudice emanuele , Nigro vincenzo , Santoro Claudia , grandone anna

Background: Congenital hypopituitarism (CH) genetics is highly heterogeneous. The massive use of NGS identified at least 21 desease causing genes. Not fully understood inheritance mechanism, incomplete penetrance and variable expressivity explain the complexity of phenotype-genotype correlations. To further complicate the scenario, the co-occurence of more than one desease-causing genes variants can geopardize the phenotype. Herein, we report the heterogeneous...

hrp0097p1-558 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Do perinatal history and mode of delivery affect age at menarche? Preliminary data of girls with Greek origin

Tsinopoulou Vasiliki-Rengina , P. Kotanidou Eleni , Bacopoulou Flora , Fidani Liana , Galli-Tsinopoulou Assimina , Christoforidis Athanasios

Objectives: Age at menarche depends on genetic, environmental, epigenetic and other factors. Studies have shown that aspects of perinatal history, including birth weight, mode of delivery (caesarian section or vaginal delivery) and gestational week at birth influence the onset of puberty. The purpose of this study was to record the age at menarche in a sample of Greek girls and to correlate it with their perinatal history, the mothers’ age at menarche, t...

hrp0097p1-559 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Longitudinal psychological and behavioral assessments in girls with precocious puberty

Poonnarattanakul Warisa , Chunin Hathaichanok , Khemakanok Sudnawa Khemika , Arunyanart Wirongrong , Phatarakijnirund Voraluck

Background: Precocious puberty (PP) in girls is defined by the appearance of secondary sex characteristic before the age of 8 years. Numerous studies reported no deficit of final adult height in girls with pubertal onset between 6-8 years compared with their genetic height, however, there were limited studies on the aspect of psychological outcomes of PP girls compare with the same age prepubertal girls.Objective: To eva...

hrp0097p1-560 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The Difference in Newly diagnosed Precocious Puberty Before and During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis

Nhat Nguyen Nam , Dang Do Tri , Hong Truong Hieu , Nam Mai Anh , Fan Hsien-Yu , Chen Yang-Ching

Keywords: precocious puberty, COVID-19Background: Studies have reported an increase in precocious puberty (PP) cases during the COVID-19 pandemic, but there is inconsistency in the findings. Various influencing factors have been proposed to explain this surge. The present study aimed to investigate the PP trend following the pandemic, examine potential influencing factors, and investigate the dose-response relationship b...

hrp0097p1-561 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Copeptin as a reliable marker in differentiating Nephrogenic Diabetes Insipidus (NDI) and Central Diabetes Insipidus (CDI)-a case study

Spilioti Diamantina-Xanthi , Minett Gemma , Rowland-Hill Chris , Douglas Linda , Gupta Sanjay

Introduction: Arginine vasopressin (AVP) and thirst are the main determinants of water homeostasis maintenance, and dysregulation leads to polyuria-polydipsia syndrome. This comprises of three key conditions: CDI due to insufficiently secreted AVP; NDI, due to renal AVP insensitivity and Primary Polydipsia (PP), caused by excessive fluid intake resulting in physiological suppression of AVP. Differentiating between these three conditions is important, as the tr...

hrp0097p1-562 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Concurrent premature gonadotrophic activation and gonadal insufficiency in young girls with a brain tumor

Evelein Annemieke , Schouten - Van Meeteren Netteke , Bakker Boudewijn , Gidding Corrie , Van der Wetering Marianne , Van Santen Hanneke

Background: It is well known that endocrine comorbidities occur frequently in children with cancer, especially in those with a brain tumor. In those children, increased intracranial pressure or hydrocephalus may lead to central precocious puberty. Furthermore, chemotherapy, especially alkylating agents, increases the risk for gonadal insufficiency. In this case series we describe 3 young girls with a brain tumor, who develop premature gonadotrophic activation,...

hrp0097p1-563 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical and analytical presentation of central precocious puberty according to age: a 20-year retrospective study

Luísa de Carvalho Ana , Matilde Carvalho Rita , Martins Sofia , Antunes Ana , Miguel Gomes Maria

Introduction: Central Precocious Puberty (CPP) results from the premature activation of the hypothalamic-pituitary-gonadal axis. Is defined by the onset of secondary sexual characters before 8-years-old in girls and 9-years-old in boys. It’s associated with accelerated growth and advanced bone maturation and can lead to early epiphyseal fusion and reduced final height at adult age.Aims: To evaluate and compare the ...

hrp0097p1-564 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

A case of Klinefelter Syndrome and peripheral precocious puberty

Deodati Annalisa , Todisco Tommaso , Ubertini Graziamaria , Bizzarri Carla , Cappa Marco

Background: Klinefelter syndrome (KS) is a genetic disorder consisting in a variable number of additional X chromosomes in a male individual. KS patients can rarely develop peripheral precocious puberty (PPP) caused by extragonadal germ cell cancers (eGCCs) producing hormones with androgenic activity. KS patients are at higher risk for eGCC when compared to the healthy populationCase report: We report the case of M., a 8...