Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

Card image cap
The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Poster Category 2

GH and IGFs

hrp0097p2-47 | GH and IGFs | ESPE2023

The Interaction between Growth Hormone (GH) -Insulin-like Growth factor 1 (IGF1) axis and Immune Systems in Infants and Children During undernutrition: Newly Discovered Pathological mechanisms.

Soliman Ashraf , Alaaraj Nada , Rogol Alan , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Soliman Nada

Accumulating evidence indicates various interactions between the GH-IGF1 axis and the immune system in infants and children during undernutrition.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on the link between the GH-IGF1 axis and the immune system in infants and children during malnutrition. We reviewed 22 studies (2007-2...

hrp0097p2-48 | GH and IGFs | ESPE2023

The Value of using IGF1/Growth Hormone Peak Ratio in Children with Idiopathic Short Stature

Soliman Ashraf , Alyafei Fawzia , Elsideeq Sohair , Hamed Noor , Ahmed Shayma , Alaaraj Nada

Introduction: Stimulated GH peak values have been shown to correlate well with nocturnal GH peak values and with nocturnal mean GH values. In addition, the expression level of serum IGF-1 in ISS has been shown to be significantly lower than that in normal children despite their normal GH peak response to provocation.Objectives: To investigate the value of using the IGF1/GH peak ratio in the anthropometric assessment of c...

hrp0097p2-107 | GH and IGFs | ESPE2023

Metabolic parameters in a series of patients with Prader-Willi syndrome treated with recombinant growth hormone

Manole Diandra , Radomir Lidia , Boboc Madalina , Brehar Andreea , Procopiuc Camelia , Iordachescu Carmen , Padure Adriana , Vladoiu Suzana , Gherlan Iuliana

Introduction: Prader-Willi syndrome (PWS) is a rare paternally inherited genetic disorder caused by alteration of chromosome 15q11-q13. Associated hypothalamic impairment leads to hyperphagia which therefore increases the risk for morbid obesity, dyslipidaemia, insulin resistance and arterial hypertension and in the end increases mortality. Patients with PWS benefit of recombinant growth hormone (rGH) treatment despite the GH reservoir to improve their impaire...

hrp0097p2-108 | GH and IGFs | ESPE2023

Acromegaly in a 14-year-old girl with pituitary adenoma

Fingerhut Karin , Krebs Andreas , Otfried Schwab Karl , Spiekerkötter Ute , van der Werf Natascha

Introduction: Acromegaly is a rare disorder, developed by overproduction of growth hormone (GH) and insulin-growth factor 1 (IGF-1), in most cases based on a pituitary adenoma. The increased IGF-1 and GH levels lead to the growth of acres and organs as well as metabolic changes. When manifesting before epiphyseal closure, a giant growth develops.Case Report: A Ukrainian girl presented at the age of 14 years with enlargem...

hrp0097p2-109 | GH and IGFs | ESPE2023

A real world experience of using Long acting Growth Hormone (Somatrogon) in Children with Growth Hormone Deficiency

Ramya Gokul Pon , Das Urmi , Dharmaraj Poonam , Ramakrishnan Renuka , Didi Mohammed , Blair Jo , Jarvis Charlotte , Laing Peter , Seniappan Senthil

Introduction: Long-acting growth hormone (LaGH) therapy has emerged as a newer treatment option for children with growth hormone deficiency, offering a convenient way of administering growth hormone (GH) injections on a weekly basis. Trials have shown that LaGH formulations are effective in increasing height velocity, improving bone mineral density, and reducing body fat mass in children with Growth hormone deficiency (GHD). The once weekly injections also hav...

hrp0097p2-115 | GH and IGFs | ESPE2023

Are there sex differences among patients to whom a growth hormone (GH) test with clonidina stimulus was required during the study of short stature?

Vela Amaya , GarcÍA Maria , Izquierdo Jon , Ugeso Alberto , Grau Gema , Rica Itxaso

Introduction: GH stimulus test is usually performed in pacientes With short stature and/or growth delayed study if GH deficit is suspected. Several articles concluded that male are more frequently diagnosed and treated of GH deficiency than femaleObjectives: To know gender's ratio and the possible anthropometric differences between patients that required a consult for short stature and to whom a stimulus test was pe...

hrp0097p2-136 | GH and IGFs | ESPE2023

Human milk insulin-like growth factors and Cyclic glycine-proline (cGP) concentrations in relation to infantile and childhood growth.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma , Soliman Nada

Introduction: Insulin-like growth factor (IGF)-1, IGF binding proteins (IGFBPs) and regulatory metabolites, including cyclic Glycine-Proline (cGP), have a possible role in modifying infant growth trajectories through their effects on linear growth, and body composition. There is no consensus on how maternal BMI affects breast milk IGF1 level.Aim: We reviewed the recent literature about human milk (IGF)-1, and cGP concent...

hrp0097p2-137 | GH and IGFs | ESPE2023

rhGH treatment in SGA patient with spondylo-epi-metaphyseal chondrodysplasia

Aquisti Giulia , Ilaria Montafia , Carlo Bianco , Federica Pagliero , Ivana Rabbone , Simonetta Bellone , Flavia Prodam , Antonella Petri , Cristina Partenope

We report rhGH-treatment results in a 14-yrs-old SGA patient with spondylo-epi-metaphyseal chondrodysplasia. The patient carries a rare de novo eterozygous variant of COLA1 (c.1510G>A, P.Gly 504Ser) associated with a rare AD spondylo-epiphyseal dysplasia. Born at term after olygohidramnios-complicated pregnancy, SGA for weight and lenght, the patient has showed a post-natal reducing growth with regular cognitive development. At the age of two height was -4 SDS, with parenta...

hrp0097p2-138 | GH and IGFs | ESPE2023

Growth hormone deficiency and Glycogen storage disease type 0 in a girl with short stature and hypoglycemia: a case report

Magdy Omar omneya , Adel Haleem Abo Elwafa, Reham , A Mahfouz Aml

Introduction: Glycogen storage disease (GSD) type 0 and growth hormone (GH) deficiency cause ketotic hypoglycemia via diverse mechanisms and are not known to be associatedCase Report: 10 years old girl presented with recurrent fasting ketotic hypoglycemia, with short stature (HSD: - 4 SDS), with Tanner stage 1, golden sample revealed glucose 42 mg /dL, low insulin and low GH, cortisol and free thyroxine levels were norma...

hrp0097p2-161 | GH and IGFs | ESPE2023

Maternal Factors affecting Human milk insulin-like growth factor (IGF) (HMIGF1) level.

Soliman Ashraf , Hamed Noor , Alaaraj Nada , Alyafei Fawzia , Ahmed Shayma , Adel Ashraf

Introduction: Accumulating evidence indicates various but significant effects of human milk IGF1 (HMIGF1) on infantile and childhood linear growth and weight gain. Studies on maternal factors affecting the level of HMIGF1 need to be clarified.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on maternal factors ...

hrp0097p2-162 | GH and IGFs | ESPE2023

Correlation between IGF-1 at diagnosis and adult height in children with short stature

Incandela Valeria , Lussu Anna , Guzzetti Chiara , Ibba Anastasia , Loche Sandro , Casula Letizia

Background: Insulin-like Growth Factor-1 (IGF-1) is an amino acid peptide produced under the effect of Growth Hormone (GH), mostly secreted by the liver, which stimulates bone growth. IGF-1 levels have high specificity and low sensitivity for the diagnosis of Growth Hormone Deficiency (GHD). Higher IGF-1 levels are classically associated with a better response to growth hormone therapy. The aim of this study was to investigate the correlation between serum IGF...

hrp0097p2-163 | GH and IGFs | ESPE2023

Taller in One Year: Early Intervention Emphasize of Growth Hormone Therapy in Children with Growth Hormone Deficiency

Muradyan Irina , Tumasyan Dalar , Manvelyan Diana , Harutyunyan Nora , Aghajanova Elena , Navasardyan Lusine

Background: Growth hormone deficiency (GHD) is a disorder affecting children's linear growth and leading to short stature without initiation of treatment with growth hormone (GH). Administration of GH has been shown to be safe and effective to increase children's final height in GHD. It is important to start the treatment as early as the GHD is diagnosed. The objective of the current study is to evaluate the growth velocity and height standard deviat...

hrp0097p2-201 | GH and IGFs | ESPE2023

Etiology and characteristics of children with short stature in endpcrinology department

Azzoug Samira , Adimi Amel , Medjani Rania , Djouadi Anes , Sadira Nesserine , Achir Samia

Objectives: childhood growth influences their social and psychological behavior, and abnormal growth may reflect underlying pathological etiologies. We aim to study etiologies and carachteristics of short stature in children in endocrinology department.Methods: 160 children ranging from 2 years to 21 years with short stature were retrospectively studied.Results: In this study, a di...

hrp0097p2-227 | GH and IGFs | ESPE2023

Study of different anthropometric factors on the patients with growth hormone deficiency before and after treatment

Razzaghy-Azar Maryam , Molaei Ziba

Background: Growth hormone deficiency (GHD) is one of the main endocrine disorders causing short stature. It may be due to isolated growth hormone deficiency (IGHD) or associated with multiple pituitary hormone deficiency (MPHD). The aim of this study was evaluation of anthropometric factors before and after growth hormone (GH) therapy.Patients and method: This is a historical cohort study. The diagnosis of GHD in childr...

hrp0097p2-234 | GH and IGFs | ESPE2023

Growth Hormone insensitivity (Laron syndrome): Report of a case.

Sanchez Urra Paulina , Linares Moreno Jeannette , Salas Cubillos Camila

Introduction: Primary growth hormone (GH) insensitivity is an autosomal recessive pathology caused by molecular defects in the GH receptor gene. In Chile there are 3 reported patients.Clinical case: Female patient, newborn of 37 weeks, due to delivery, adequate for gestational age. Son of non-consanguineous parents. Hospitalized at 12 hours of life in the neonatology unit due to persistent tremors, jaundice and septic sy...