ESPE Abstracts

Introduction: GH stimulus test is usually performed in pacientes With short stature and/or growth delayed study if GH deficit is suspected. Several articles concluded that male are more frequently diagnosed and treated of GH deficiency than female

Objectives: To know gender's ratio and the possible anthropometric differences between patients that required a consult for short stature and to whom a stimulus test was performed with clonidine during 3 years.

Patients and Methods: We retrospectivelly reviewed all patients sent to a specialised ofrece between 2015 to 2017 due to short stature and/or growth delayed, in which a clonidine stimulus test was performed between. Patients with chronic diseases, syndromes, and patients diagnosed of oncologic diseases were excluded. Clonidine stimulus test was carried out in the morning. Pacientes came to the hospital fasting hospital during the day, fasting, and the clonidine dose was weight dependant. After the administration of clonidine, GH levels were measured at minute 0, 60, 90, and 120 with a chemiluminescence Immunoassay with Inmulite 2000 (Siemens). For standard deviation conversion, we used local growth graphics. SPSS V25 was usted for statistical analysis

Results: 108 patients (39% girls) were included; mean age was 10.7 years. 65% were Prepubertal patients. Variables: Height-SDS, BMI-SDS and Target-Height (TH)-SDS.

More than 75% of the patients had low weight. Only eight patients had obesity or overweight. Of them, seven had not response to the clonidine stimulus. All patients excepto two were below their mid parental height. Even if there was a peak in the answer at every time, the 90% was present in the minutes 60 and 90 (52% in the minute 60 and 33% in the minute 90). During follow-up, 30% were finally diagnosed and treated as GH deficit (30% of the girls and 29% of the boys). No significant differences.

Conclusions: 1. In our series, male did not benefit from the diagnostic and treatment of GH deficiency. 2. In this samples, most of the patients that participated, presented low weight, a factor that may affect in the adequate growth rate.