ESPE Abstracts

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Diabetes mellitus is a bihormonal disorder involving both insufficient insulin secretion (from the beta-cells(and dysregulation of glucagon secretion (from the alpha-cells). In healthy people, a fall in plasma glucose increases glucagon and stimulates counterregulatory hepatic glucose production. This response is impaired in many patients with type-1 diabetes (T1D). Why this defect develops is unknown but it may lead to fatal hypoglycaemia, which accounts for up to 10% of the ...