ESPE2023 Poster Category 1 Growth and Syndromes (75 abstracts)
Which Method is More Effective in Predicting Adult Height in Pubertal Girls Treated with Gonadotropin-Releasing Hormone Agonist?
Gözde Akın Kağızmanlı 1 , Reyhan Deveci Sevim 2 , Özge Besci 1 , Kübra Yüksek Acinikli 1 , Ayşen Hazal Buran 3 , İbrahim Mert Erbaş 1 , Ece Böber 1 , Korcan Demir 1 , Ahmet Anık 2 & Ayhan Abacı 1
1Dokuz Eylül University Faculty of Medicine, Division of Pediatric Endocrinology, İzmir, Turkey. 2Adnan Menderes University Faculty of Medicine, Division of Pediatric Endocrinology, Aydın, Turkey. 3Dokuz Eylül University Faculty of Medicine, Department of Pediatrics, İzmir, Turkey
Purpose: The aim of the present study was to determine the efficiency of three different predictive models [Bayley-Pinneau (BP), Roche-Wainer-Thissen (RWT), and Tanner-Whitehouse 2 (TW2)] by comparing their predictions with near-adult height (NAH) data of girls who received gonadotropin-releasing hormone agonist (GnRHa) therapy.
Methods: Clinical findings were retrospectively analyzed. Bone age (BA) was determined by three different investigators (AA, KD, AA) using the Greulich-Pyle (GP) atlas and TW3-RUS method, which were obtained from left wrist radiographs taken at the time of diagnosis. Predicted adult height (PAH) was calculated using the BP, RWT, and TW2 methods for each patient at the beginning of therapy.
Results: The median age at diagnosis of the forty-eight patients included in the study was 8.8 (8.9-9.3) years. The mean height standard deviation (SD) score of the patients was 1.1±1.4 [(-1.8) - (4.5)]. There was no significant difference between the mean BAs evaluated separately with the GP atlas and the TW3-RUS method (P=0.34). The mean target height and NAH SD scores of the patients were -0.6±0.9 [(-3.0) - (2.0)] and -0.5±1.1 [(-2.5) - (2.2)], respectively (P=0.56). Among the PAH methods, only PAH measured by the BP method was very close to and no different from NAH [159.8±6.3 vs. 158.8±9.3 cm. P=0.3; (-0.5±1.1) vs. (-0.7±1.6) SD score, P=0.1]. The sensitivity, specificity, and accuracy rates of methods in predicting the difference between the NAH SD score and the target height SD score higher than -0.5 SD score were determined as 77%, 46.2%, and 68.8% for BP; 73%, 36.4%, and 64.6% for RWT; and 65.8%, 10%, and 54.2% for TW2, respectively. Accordingly, the BP method was the most accurate prediction tool in girls with puberty treated with GnRHa.
Conclusion: The BP method is more effective at predicting adult height than the RWT and TW2 methods in female patients who received GnRHa treatment.
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