ESPE2023 Poster Category 1 Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology (56 abstracts)
Hyperandrogenism in adolescents assigned female at birth during process of gender incongruence/ gender dysphoria diagnosis
Aneta Gawlik 1 , Aleksandra Antosz 1 , Iga Chmiel-Aleksandrowicz 1 , Aleksandra Januszek-Trzciąkowska 1 , Dorota Karbowska 1 , Jakub Gawlik 2 , Zuzanna Nowak 2 & Tomasz Jakubowski 1,3
1Department of Pediatrics and Pediatric Endocrinology, Faculty of Medical Sciences, Medical University of Silesia, Katowice, Poland. 2Student Scientific Society at the Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland. 3Faculty of Social Sciences, Institute of Psychology, University of Silesia in Katowice, Katowice, Poland
Introduction: Gender incongruence (GI) is a condition where a person's gender identity does not match their assigned sex at birth and can lead to significant distress and gender dysphoria (GD). Some studies have shown a higher prevalence of hyperandrogenism (HA) in transboys/transmen than among the cisgender female population and considered its meaning in the context the of gender identity development. Therefore, further studies confirming this observation and clarifying the relationship between HA and GI/GD is needed. In our study we conducted clinical and biochemical assessment for HA in a population of adolescents with GI/GD during their diagnosis process and before medical transition.
Methods: This prospective study has examined assigned female at birth (AFAB) adolescents admitted due to GI/GD to one clinical center between 2017 and 2022. History of gender incongruence/gender dysphoria has been analysed alongside clinical and hormonal parameters.
Results: The population consisted of 153 participants, with the median age of 16.1 ± 1.7 years and the mean age of gender identity mismatch onset of 11.7 ± 2.5 years. The prevalence of hirsutism, acne and oligomenorrhoea (>35 days) in study group was 1%, 42% and 10% respectively. Biochemical HA / hyperandrogenemia defined by concentration of serum testosterone (>58 ng/dl), androstenedione (>2.24 ng/ml), DHEAS (>248 µg/dl) and 17-hydroxyprogesterone (>2.0 ng/ml) was confirmed in 14%, 65%, 38% and 24% participants respectively.
Conclusion: This is the first study to assess the prevalence of hyperandrogenism in AFAB adolescents with gender incongruence in Polish population. Our findings point to a high prevalence of biochemical than clinical markers of HA among the AFAB population.
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