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ESPE Abstracts (2023) 97 P1-501

ESPE2023 Poster Category 1 GH and IGFs (48 abstracts)

The Predictive Value of using IGF1/Growth Hormone Peak Ratio on growth parameters in Children with Growth Hormone Deficiency (GHD) before and after GH treatment.

Ashraf Soliman 1 , Fawzia Alyafei 1 , Nada Alaaraj 2 , Noor Hamed 1 , Shayma Ahmed 3 , Sohair Elsiddig 1 & Nagwa Eldarsy 1

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1Hamad General Hospital, Doha, Qatar. 2Hamad General hospital, Doha, Qatar. 3Hamad general hospital, Doha, Qatar

Introduction: GH stimulates the production of IGF1; however, their metabolic effects are different. GH has lipolytic and anti-insulin actions while IGF1 has insulin-like actions.

Objectives: To investigate the value of using the IGF1/GH peak ratio in relation to the anthropometric data of children with growth hormone deficiency (GHD) before and after a year of GH therapy.

Patients and Methods: 22 short children with GHD (HtSDS < -2, with peak GH response to provocation < 7 mcg/L) were studied. Their IGF1 level and their peak GH response to provocation were analyzed in relation to their growth data for 1 year on GH treatment (0.3 to 0.5 mg/kg/day) for 1 year.

Results: summarized in 3 tables

Table 1: The growth and hormonal data of children with ISS.
GHD Age wt Ht HtSDS BMI BMI SDS MPHSDS IGF-I IGF1SDS GH-P IGF1/GHP
mean 9.99 27.51 124.1 -2.22 16.99 -0.40 -0.98 158.3 -0.99 4.95 37.30
SD 3.07 11.57 18.01 0.69 3.21 1.17 1.14 102.3 1.09 1.59 31.45
Age2 wt2 Ht2 HtSDS 2 BMI2 BMI SD2 wt gain g/day IGF-1 2 IGF-1SDS 2 Delta BMISD Delta HTSD
mean 10.9 32.8 131.9 -1.79 17.88 -0.12 13.03 268 0.85 0.24 0.46
SD 3.25 13.57 19.39 0.65 3.27 0.98 7.59 152.6 1.05 0.42 0.42
Table 2: Correlations between IGF1, GHP, and IGF1/GHP ratio on anthropometric data before GH treatment.
Age weight Height HtSDS BMI BMI SDS IGF-I
IGF-I 0.64 0.78 0.73 0.67 0.64 0.36 1.00
GH-P 0.01 -0.12 0.04 0.13 -0.30 -0.32 0.12
IGF1/GHP 0.52 0.78 0.59 0.53 0.80 0.52 0.64
Table 3: Correlations between IGF1, GHP, and IGF1/GHP ratio on anthropometric data after GH treatment.
GH-P IGF1SDS IGF1/GHP
GH-P 1.00 0.19 -0.53
IGF1/GHP -0.53 0.39 1.00
Age1 0.02 0.01 0.52
weight1 -0.11 0.34 0.78
Height1 0.01 0.18 0.61
Height SD1 -0.06 0.65 0.67
BMI1 -0.24 0.42 0.82
BMISD1 -0.27 0.54 0.60
Age2 0.01 0.02 0.54
weight2 -0.08 0.27 0.79
Height2 0.02 0.14 0.61
HeightSD2 -0.01 0.58 0.67
BMI2 -0.18 0.34 0.83
BMI SD2 -0.08 0.41 0.47
wt gain g/day -0.15 -0.02 0.61
IGF1-2 0.00 0.64 0.83
IGF1/GHP ratio correlated better with the growth parameters compared to IGF1SDS, both before and after a year of GH. IGF1/GHP ratio correlated significantly with IGF1 increment and weight gain/day after 1 year of GH therapy.

Conclusion: The IGF1/GHP ratio has a good predictive value of growth response to GH therapy in GHD children

Volume 97

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61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

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The Predictive Value of using IGF1/Growth Hormone Peak Ratio on growth parameters in Children with Growth Hormone Deficiency (GHD) before and after GH treatment (<1 min ago)

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