ESPE Abstracts

Keywords: Endocrine, Non-cystic fibrosis bronchiectasis, Interstitial Lung Disease (ILD)

Introduction: Recent evidence shows that there is association between different endocrinal disorders and the pathogenesis of chronic lung diseases. These disorders have an impact on quality of life and management of these diseases.

Aim of work: Assess the correlation between two chronic lung diseases (interstitial lung diseases (ILD) and non-cystic fibrosis bronchiectasis) and different endocrine disorders including diabetes, thyroid abnormalities, calcium disorders.

Patients and Methods: This study was conducted as a cross sectional analytic study and included 50 patients diagnosed with chronic lung disease (ILD and non-cystic fibrosis bronchiectasis) attending the Pediatric pulmonology outpatient clinic and Department. Each patient underwent: Full history taking, thorough clinical examination and laboratory investigations (Blood glucose: (Fasting and 2 hours post prandial blood glucose), HbA1c, thyroid profile, calcium profile:(calcium, phosphorus, alkaline phosphatase, parathormone, vitamin D), and basic laboratory investigations as (CBC, liver function tests, serum albumin…etc).

Results: Among the studied population 15(30%) of patients were prediabetic, (20% had impaired fasting glucose, 100% had impaired glucose tolerance). Twenty (40%) were diabetic (85% diagnosed as type 1 diabetes and 15% diagnosed as drug induced diabetes). Hypothyroidism was evident among 13(26%) of the study group. Vitamin-D insufficiency was evident among 8(16%) and was deficient among 17(34%) of the study group. Furthermore, 3(6%) had hypoparathyroidism, 1(2%) had hyperparathyroidism. By comparing the 2 subgroups, (ILD and non-cystic fibrosis bronchiectasis) regarding anthropometric measures (height and weight), ILD group has shown more stunted growth compared to bronchiectasis group with statistically significant difference with p values 0.013 and 0.008 respectively. Bronchiectasis group had more hypocalcemia, hypophosphatemia and more vitamin D deficiency compared to ILD group with statistically significant difference with p values 0.022, 0.007 and 0.035 respectively.

Conclusion: There is increasing evidence that several endocrinal and metabolic disorders were detected among children with chronic lung diseases. That’s why screening for endocrinal disorders in those patients is mandatory for early diagnosis and treatment to ameliorate the clinical course of the disease and improve the outcome.