ESPE Abstracts (2023) 97 P1-537

ESPE2023 Poster Category 1 Multisystem Endocrine Disorders (28 abstracts)

Effects of seasonal variability of insolation and COVID-19 pandemic isolation on vitamin D concentrations in children

Joanna Smyczyńska 1 , Maciej Hilczer 2 , Anna Łupińska 2,3 , Natalia Pawelak 2 , Andrzej Lewiński 2,4 & Renata Stawerska 2,3

1Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical Unversity of Lodz, Lodz, Poland. 2Department of Endocrinology and Metabolic Diseases, Poilsh Mother's Memorial Hospital - Research Institute, Lodz, Poland. 3Department of Pediatric Endocrinology, Medical University of Lodz, Lodz, Poland. 4Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland

Introduction: Vitamin D may be considered as a hormone of prohormone of pleiotropic effects. Seasonal variability of insolation affects its synthesis in humans. In our latitude, vitamin D deficiency is widespread. In 2018, updated recommendations for vitamin D supplementation were published in Poland by Rusińska et al. In 2020, SARS-CoV-2 pandemic lockdown was introduced, with suggestions of protective anti-viral vitamin D role.

Aims to investigate the effects of: 1. seasonal variability of insolation, 2. updating guidelines of vitamin D supplementation 3. limited sun exposure during pandemic lockdown and recommendations to increase vitamin D supplementation on 25(OH)D concentrations in children.

Methods: Retrospective analysis of the long-term variability of 25(OH)D concentrations was performed in a group of 1440 children (879 boys, 561 girls) with short stature, aged 3.0-18.0 years. Concentrations of 25(OH)D were compared between the periods from mid-2014 to mid-2018 (Group A), from mid-2018 to mid-2020 (Group B) and from mid-2020 to mid-2022 (Group C). Vitamin D deficiency was defined as 25(OH)D <20 ng/ml, suboptimal supply 20-30 ng/ml. Due to the lack of normal distribution of 25(OH)D concentrations in Shapiro-Wilk test, nonparametric Kruskall-Wallis test was applied for comparisons between groups, followed by post-hoc Bonferroni-Dunn test. Next, time series regression model of seasonal variability of 25(OH)D concentrations was created.

Results: In the whole group median (25-75centile) 25(OH)D concentration was 24.0 (18.3-30.2) ng/ml, in Groups A, B and C it was 22.9 (17.3-28.7) ng/ml, 26.0 (20.0-30.7) ng/ml and 29.9 (21.3-34.3) ng/ml, respectively, with significant (P<0.05) differences between all Groups. Concentrations of 25(OH)D were normal in 26.1% children, suboptimal in 41.9%, deficient in 32.0%. Time series model including insolation in previous 3 months explained 80% of pre-pandemic seasonal variability of 25(OH)D concentrations, however during pandemy with overprediction for 1st while underprediction for 2nd year (that probably reflects reduced sun exposure during lockdown and increasing vitamin D supplementation).

Conclusions: Significant increase of 25(OH)D concentrations was observed both after the update of supplementation guidelines and during SARS-CoV-2 pandemic, however the scale of vitamin D deficiency and insufficiency is still too high. Seasonal vitamin D supplementation is necessary in paediatric population. Further efforts to improve the vitamin D supply in children should be taken, including updates of recommendations, as it has recently been done in Poland (Płudowski et al. 2023).

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.