ESPE2023 Poster Category 2 Diabetes and Insulin (27 abstracts)
Celiac and Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitus
Versha Rani Rai , Heeranand Rahore , Zubair Khoso , Maira Riaz , Saadullah Chachar & Mohsina Noor Ibrahim
NICH, KARACHI, Pakistan
Keywords: Anti-GAD antibodies, Anti-thyroid antibodies, celiac disease, HbA1c, type-1 diabetes mellitus. We analyze the association of anti-GAD positive type-1 diabetes mellitus (T1DM) with anti-thyroid antibodies and celiac disease. We analyzed children of both gender and aged between 1 to 18 years having known T1DM. Blood sample of each child was taken in sterilized container and sent to institutional laboratory for biochemical investigations. In a total of 115 patients, 67 (58.3%) were female and 48 (41.7%) male. The mean age was 8.87±3.43 (ranging between 1.5 to 17 years). The mean HbA1c was 11.86±7.31%. It was found that anti-GAD IgG was having signification association with celiac disease (P<0.001). Significant correlation of anti-GAD positive antibodies with Ttg-IgG antibodies (correlation coefficient=0.303, P=0.001), thyroid peroxidase antibodies (correlation coefficient=0.228, P=0.001). High proportions of children with anti-GAD positive T1DM patients were found to have thyroid disorders and celiac disease. Significant correlation was found between anti-GAD positive antibodies, celiac disease and anti-thyroglobulin antibodies.
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