ESPE Abstracts (2023) 97 P2-27

1Vall d'Hebron University Hospital, Barcelona, Spain. 2Josep Trueta University Hospital, Girona, Spain

Introduction: Differential diagnosis of partial arginine vasopressin deficiency (P-AVPD) and primary polydipsia (PP) can be challenging. Arginine-stimulated copeptin concentrations have been used to differentiate between arginine vasopressin deficiency (AVPD) and PP, setting a copeptin value of 3.8pmol/L at 60 min as a cut-off point in adults.

Objective: To evaluate the efficacy and safety of the arginine-stimulated test in paediatrics.

Methods: Descriptive and prospective study on a diagnostic method in six paediatric patients with polydipsia-polyuria syndrome (PPS).

Inclusion criteria: Patients under 18 years with polyuria (>2mL/kg/h), normal glycaemia and no electrolytic changes. The arginine-copeptin test is performed with analytical control and vital signs (Times: basal, 0', 30', 60', 90', 120'). Patients description and results (Table 1 and 2): -Patient 1: 5-year-old boy with sudden PPS and MRI showing hypoplastic adenohypophysis and absence of neurohypophysis signal. Arginine-copeptin test <3.8pmol/L. -Patient 2: 12-year-old boy with long-standing PPS and syntelencephaly without alterations in the hypothalamic-pituitary region. Arginine-copeptin test >3.8pmol/L. -Patient 3: 13-year-old boy with sudden PPS. MRI showed an absence of the neurohypophysis and thickening of the pituitary stalk, etiological study pending. Arginine-copeptin test <3.8pmol/L. -Patient 4: 3-year-old girl with SGA, monosomy X, and Kabuki-like syndrome with long-standing PPS. MRI without alterations in the hypothalamic-pituitary axis. Arginine-copeptin test >3.8pmol/L. -Patient 5: 4-year-old girl with long-standing PPS. Arginine-copeptin test >3.8pmol/L. -Patient 6: 10-year-old boy with GH deficiency under treatment and MRI showing interruption of the pituitary stalk and ectopic neurohypophysis. He presents long-standing PPS. Arginine-copeptin test >3.8pmol/L. All patients were asymptomatic and hemodynamically stable during the procedure. Blood tests at the beginning and end of the test show no alterations.

Table 1: Water-restriction test
1 2 3 4
Duration (hours) 15 17 Basal (without restriction; plasma osmolality of 303mOsm/Kg) 10
Urinary osmolarity before Desmopressin (mOsm/kg) 601 495 98 304
Urinary osmolarity after Desmopressin (mOsm/kg) 845 687 507 415
Table 2: Arginine-copeptin test
1 2 3 4 5 6
Copeptin (pmol/L)
Basal 2,4 3,8 1,61 4.42 2.7 3,94
30’ 2,5 4 1,48 5.24 3 5,3
60’ 2,3 4,13 1,78 8.44 4.8 5,2
90’ 1,8 3,8 1,98 4.5 6
120’ 2,4 1,47 9.72 3.7 5,8
180’ 3.7 4,5

Conclusion: The arginine-stimulated copeptin test is a safe procedure and can represent an alternative to the diagnosis of AVPD.

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

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