ESPE Abstracts

Key words: growth hormone defificiency，growth hormone, height，bone age

Objective: To evaluate the height and bone age (BA) of prepubertal growth hormone deficiency (GHD) children in the first year after long-term growth hormone treatment.

Methods: According to the degree of bone age lag before treatment，36 prepubertal GHD children were divided into two groups（Group 1: bone age lagged behind chronological age ≥1; Group 2: bone age lagged behind chronological age <1）. The data of their height, weight, secondary sexual characteristics, serum IGF-1 and bone age during the treatment with long-acting growth hormone were analyzed retrospectively.

Results: Two groups of children with GHD were treated with growth hormone for one year, Δ HtSDS was 0.93±0.27 and 0.95±0.37, respectively, with no significant difference; and ΔBA was 1.58±0.67 and 1.02±0.39, respectively, with statistical significance.

Conclusion: In the first year of long-term growth hormone treatment, there was significant height improvement and acceleration of bone age progression in prepubertal GHD children. The degree of bone age backwardness before treatment does not affect the improvement of height of pre pubertal GHD children, but may affect the progress of bone age.