ESPE2023 Poster Category 2 Adrenals and HPA Axis (37 abstracts)
Final Adult Height in Saudi patients with Congenital Adrenal Hyperplasia
Ibrahim Al Alwan 1,2,3 , Edi Shafaay 1 , Mohammed Aldriweesh 1,2 , Ghadeer Aljahdali 1,2 , Abdulrahman Alomar 1 , Khulood Alharbi 4 , Haneen Aldalaan 5 , Ahmed Alenazi 5 , Afaf Alsagheir 5,6 , Abdulaziz S. Alangari 3,7 & Amir Babiker 1,2,3
1kingSaud Bin Abdualziz University for health sciences, Riyadh, Saudi Arabia. 2King Abdulaziz Medical City, Riyadh, Saudi Arabia. 3King Abdullah International Research Centre, Riyadh, Saudi Arabia. 4Department of Pediatrics, Taibah University, Madinah, Saudi Arabia. 5King Faisal Specialist hospital and Research centre, Riyadh, Saudi Arabia. 65. College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. 7Department of Epidemiology and Biostatistics, College of Public Health and Health Informatic, King Saud Bin Abdulaziz University for health sciences, Riyadh, Saudi Arabia
Introduction: Congenital Adrenal Hyperplasia (CAH) is a chronic disease that requires life-long hormonal replacement therapy. Growth of patients with CAH can be affected by this therapy or the hyperandrogenic effect of the disease. In this study, we aimed to assess the potential effect of CAH and its therapy on final height in Saudi affected patients.
Methodology: This is a retrospective cohort study from two tertiary endocrine centres in Riyadh, Saudi Arabia. We included all patients above 19 years of age diagnosed with CAH. Clinical data were collected from patients' medical records and we used SPSS in statistical analysis.
Results: A total of 92 patients were included [54.4% (n=50) female); mean age for males was 25.6 (+/-6.4) year and 26 (+/-6.6) year for females]. Two adult females (46XX) were permanently raised as males in our cohort. CYP21 gene defect was the most common 94.4% (n=85), followed by CYP11 5.4% (n=5), then HSD3 2.2% (n=2). Mean final Height (cm)(SD) in males was 156.3 (9.5) and in females was 148.9 (7.2). Final height of CAH patient compared to Saudi population was -1.69 SD and -1.07 SD in males and females, respectively.
Conclusion: Our CAH adult patients had significant impairment of their final height that could be related to genetic defect or gender or medications side effect. Males were more affected in our cohort. This may require special attention to their growth during childhood to offer an appropriate and early intervention.
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