ESPE Abstracts

The aim of this study was to investigate that exposure metabolites of phthalate one of the endocrine disruptors might be different in sex and might have influenced from obesity and insulin resistance in Korean children and adolescents. Nationwide data of 551 subjects aged 8-15 years (boys 281 and girls 270) who were included the study from 2010-2011. Subjects were grouped by sex and BMI percentile (normal: BMI<85p; overweight: 85P≤BMI<95p; obese: ≥95p). We examined anthropometric parameters of subjects and calculated body mass index. We estimated the amount of endocrine disruptors according to 24 hour recall record, metabolites of phthalates (MEP, MiBP, MnBP, MEHP, MiNP, MEOHP, MBzP, and MEHHP) from random urine and serologic parameters of fasting insulin, fasting glucose, and HOMA-IR. We clarified the correlation between metabolites of phthalate and obese trends using Pearson regression analysis. Urine level of MEOHP (µg/g cr) was higher in boys (boys vs girls; 35.92 vs 30.46, p =0.0158). There were more food exposure of metabolites of phthalate (µg/day) in boys (DBP: boys vs girls; 10.72±3.45 vs 9.94±3.10, P=0.0058, DEHA: boys vs girls; 13.75±4.55 vs 12.52±3.95, P<0.01, DEHP: boys vs girls; 59.92±21.84 vs 54.97±18.67, P<0.01). In boys, urine level of MEOHP (µg/g cr) was inversely correlated with obese tendency (r: normal vs overweight vs obesity; -0.366 vs -0.478 vs -0.580, P<0.01). DEHP (µg/kg/day) was inversely correlated with obese tendency (r: normal vs overweight vs obesity; -0.621 vs -0.650 vs -0.723, P<0.01). In girls, u-MnBP was inversely correlated with obese tendency (r: normal vs overweight vs obesity; -0.371 vs -0.555 vs -0.847, P<0.01). u-MEOHP was inversely correlated with obese tendency (r: normal vs overweight vs obesity; -0.413 vs -0.686 vs -0.698, P<0.01). u-MEHHP was inversely correlated with obese tendency (r: normal vs overweight vs obesity; -0.379 vs -0.529 vs -0.826, P<0.01). In boys, u-MiBP, u-MEHP, u-MEOHP, BBP, DBP, DEHA, DEHP, and ΣDEHP were inversely correlated with fasting glucose, and HOMA-IR (P<0.01). In girls, u-MiBP, u-MEHHP, BBP, DBP, DEHA, DEHP, and ΣDEHP were inversely correlated with fasting insulin and HOMA-IR (P<0.01). In conclusion, metabolites of phthalates exposed via food ingestion were different in sex and body adiposity. Therefore we suggested that body adipose organ might interact with metabolites of phthalate in Korean children and adolescents.