ESPE Abstracts

Objective: As obesity rates rise among children, non-alcholic fatty liver disease (NAFLD) is becoming more prevalent. Although liver biopsy is considered the gold standard for diagnosing NAFLD, it is an invasive procedure and not practical for screening. Asprosin, a recently unveiled adipokine, is released in response to fasting. In this study, we aim ed to investigate the diagnostic value of asprosin for NAFLD in obese patients....

Background: The global prevalence of childhood and adolescent obesity has surged since 1980, reaching 107.7 million cases in 2015. Notably, 23% of children in developed countries are overweight or obese. The Atherogenic Index of Plasma (AIP) emerges as a novel, robust biomarker, closely linked to obesity, and serves as a reliable indicator of dyslipidemia and associated conditions, including cardiovascular diseases.Aim: ...

Objective: Pediatric hypertriglyceridemia (HTG), has considerable phenotypic and genotypic variability. We aim ed to describe the clinical and genotypic profile of Indian children presenting with severe HTG.Methods: This retrospective study (January 2022-December 2023) was conducted in children up to 12 years of age. Those presenting with severe HTG (triglycerides >500 mg/dL) were included after exclusion of known sec...

Background: Vitamin D deficiency has been shown to increase fatty liver disease (FLD) incidence in patients with obesity (4,5). This study aim ed to determine the effects of a single dose of 300,000 IU cholecalciferol on insulin resistance and fatty liver disease (FLD) in children with obesity with vitamin D deficiency.Methods: In this clinical study, 128 patients aged 8-18 years with obesity and vitamin D deficiency wer...

Objective: To analyze the correlation between glucose metabolism disorder and bone turnover markers in obese adolescents.Methods: From June 2022 to June 2023, 50 obese adolescents in West China Second Hospital of Sichuan University were taken as the research group, and 50 adolescents with normal weight who received health examination at the same time were taken as the control group. The general data, glucose metabolism i...

Introduction: Childhood obesity has reached epidemic proportions in contemporary societies with multiple comorbidities. Social stigma, low self-esteem, depression, anxiety, and behavioral problems are noted in youth with excess adiposity, and may persist for a long time. The aim of our study was to assess the alterations in cardiometabolic risk factors and mental health in children and adolescents with excess adiposity following the implementation of a multidi...

Objective: Hypothalamic obesity does not respond well to conventional interventions for obesity. Glucagon-Like Peptide 1 (GLP-1) receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. This systematic review summarizes the efficacy and safety of GLP-1 receptor agonists use in hypothalamic obesity.Design: A PRISMA-compliant systematic review ...

Objective: Craniopharyngiomas, diagnosed and treated during childhood, pose significant challenges due to their location in the sella turcica, adjacent to the pituitary and hypothalamus. Patients often experience endocrine deficiencies which may affect their body composition and metabolic health. We aim ed to explore the body composition components and their interaction with metabolic syndrome components in pediatric patients with craniopharyngioma following n...

Objective: PWS is a rare genetic imprinting disorder resulting from the expression loss of genes on the paternally inherited chromosome 15q11-13. Early-onset life-thriving obesity and hyperphagia represent the clinical hallmarks of PWS. The noncoding RNA gene SNORD116 within the minimal PWS genetic lesion plays a critical role in the pathogenesis of the syndrome.Methods: We collected inguinal white adipose tissues (ingWA...

Background and aims: Craniopharyngiomas (CPs) are rare, non-malignant tumors near the pituitary and hypothalamus. Besides surgery, radiotherapy plays an important role in the treatment strategy. Both tumor-related factors and treatment can cause severe obesity and neuroendocrine disorders. Clinical studies have shown that endocrine deficits can occur at a dose level of 18Gy and risk increases with higher doses. Proton therapy (PT) is increasingly used in order...

Background: The diagnosis of monogenic obesity is burdened by frequent variants of uncertain significance (VUS). We aim ed to describe our real-life approach of variant re-assessment over time for managing classification uncertainty in the diagnosis of monogenic obesity, and to infer if population data updates and novel functional evidence are decreasing inconclusive variants.Methods: We tested 101 children/adolescents (...

The mineralisation measured by DXA, bone-mineral-content (BMC), of obese boys seems to be better than that of lean boys and It is known that obese children are taller than healthy children. Is this the only factor that explains the better DXA measurements of obese boys? And how explain the fact that these boys have more fractures of the extremities? We described bone mineralization in boys with overweight/obesity and leanness in relation to body composition. Cross-sectional st...

Introduction: Insulin resistance accelerates the onset of atherosclerosis and arterial stiffness in children. Trimethylamine N-oxide (TMAO), a gut-derived metabolite linked to cardio-metabolic issues in adults, could exacerbate these conditions in children as well. This study explores how insulin resistance and serum TMAO levels relate to vascular damage in obese children.Methods: We included 60 children aged 6 to 18, di...

Background: Congenial Leptin deficiency (CLD) manifests as severe obesity, hyperphagia, and metabolic complications. While Metroleptin is the treatment of choice, its cost makes it inaccessible for many. We present two sisters, aged 14 and 7, diagnosed with CLD, who had significant improvement with the glucagon-like peptide-1 (GLP-1) receptor agonist, Semaglutide. Both experienced notable reduction in body weight and metabolic markers with Semaglutide, highlig...

Pediatric obesity is intimately related to the development of Metabolic Syndrome (MetS), which is a cluster of metabolic alterations associated with an increased risk of premature death. Some indexes of obesity, such as the Triponderal Mass Index (TMI), Body Mass Index (BMI), and Body Mass Index z-score (BMI-zscore), are used to identify children at high risk. This study aims to compare the discriminative ability of BMI, BMI and BMI-zscore to determine the risk of developing M...

Introduction: Syndromic obesities are characterized by malformations, dysmorphic features, and/or neurodevelopmental disorders. This paper reports the clinical characterization of a duplication showing familial transmission in the Xq27.3q28 region containing the FMR1 gene, presenting symptoms such as obesity, hypogonadism, gynecomastia, short stature, and intellectual disability.Case Presentation: A 17-year-old male pati...

Aims: The aimof this study was to investigate the prevalence and risk factors of MAFLD in severely obese polish children and adolescents.Patients and Methods: Data were collected in four Polish medical centers as a part of the project "Prevalence of monogenic obesity among Polish children and adolescents with severe obesity" (funded by National Science Center, Poland (2021/41/B/NZ5/01676)). Inclusion criteria f...

Background: Childhood obesity presents a significant global health concern, leading to long-term morbidity and mortality. While lifestyle interventions remain fundamental, pharmacological approaches, particularly using glucagon-like peptide-1 (GLP-1) receptor agonists, show promise in certain patient populations. However, studies exploring this avenue, particularly in the Middle East and North African region, are limited. This study aims to share our experienc...

Background: Obesity is increasingly being diagnosed in the paediatric population. Obesity during childhood and adolescents is related to an increased risk for cardiovascular diseases, high blood pressure, diabetes mellitus and menstrual disorders including heavy menstrual bleeding, oligomenorrhea, dysmenorrhea. The study aim: is to investigate the incidence of menstrual disorders in adolescents with severe obesity. <...

Objectives: We can notice that in Poland and around the world, the number of obesity cases in the pediatric population is increasing spectacularly. Metabolic syndrome, which can be recognized and treated in childhood, is often neglected during this period. As a result, in adult life it may increase the risk of cardiovascular diseases development dependent from VEGF. That is why it is so important to diagnose and treat obesity in childhood, thanks to therapeuti...

Aim: Physical damage to hypothalamus, can lead to autonomic dysregulation, temperature imbalance, increased appetite, and obesity. We aim ed to determine the risk factors for the development of hypothalamic obesity.Methods: The cases were evaluated based on location, size of the mass, treatment modality (surgery or radiotherapy), pathology result, presence of hydrocephalus, family history of consanguinity and obesity, co...

Introduction: Childhood obesity is associated with various physical and mental health co-morbidities. Lifestyle interventions remain the mainstay of management in children & young people (CYP) with obesity. Semaglutide, a Glucagon-like peptide 1(GLP1) analogue, is licensed for managing obesity in CYP older than 12 years of age.Aim: The aimof this study is to look at the effects of semaglutide on glycaemic status, bod...

Introduction: The coexistence of asthma and obesity presents a significant clinical challenge, as both conditions independently contribute to systemic inflammation, metabolic dysregulation, and impaired respiratory function. Metabolic markers can potentially provide insights into the pathophysiological mechanisms that link obesity and asthma. The aimof this study was to investigate the association between metabolic markers, vitamin D and lung function in child...

Background: The worldwide prevalence of pediatric obesity has increased in recent decades, also in East Asia with environmental and lifestyle changes. Due to differences in obesity definitions and country-specific growth charts, direct comparisons of obesity prevalence across countries may not be appropriate. We aimto analyze the changes in weight distribution and the trends and patterns of pediatric obesity in China, Japan, South Korea, and Taiwan using WHO c...

Background: Central obesity among adolescents has been on the rise globally and there is ample evidence that to suggest that central obesity is a strong predictor of cardiovascular disease and Type 2 Diabetes.Aims/Objectives: To determine the prevalence of Central Obesity among adolescent school children aged 14-18 years in rural Kerala.Methods: A descriptive cross-sectional, schoo...

Introduction: Mandibular hypoplasia, Deafness, Progeroid features, Lipodystrophy (MDPL) syndrome is a rare autosomal dominant disorder caused by mutation in POLD1 gene, which encodes the catalytic subunit of the DNA polymerase delta (Polδ) enzyme.Case: a 6.5-year-old boy presented to the outpatient clinic due to severe thinness (BMI -4.86 SDS, WHO 2006 growth charts). Examination of his medical history rev...

Background: Severe hypothalamic obesity (HO) is frequent sequelae in craniopharyngioma (CP) patients after surgery with or without radiotherapy. The pathophysiological mechanisms behind HO include impairment of the hypothalamic structures controlling satiety and energy expenditure. Weight gain often continues despite adequate pituitary hormone substitution, and conventional lifestyle changes as exercise and reduced caloric intake rarely have a lasting weight r...

Introduction: The substantial increase in prevalence of childhood obesity presents a major challenge. Obesity is associated with significant physical and mental co-morbidities including diabetes and cardiovascular disease. Successful treatment requires intensive input from a specialist multidisciplinary team. In 2019, NHS England initiated a pilot to treat Complications Relating to Excess Weight (CEW) in dedicated clinics across the country. Facilitating suffi...

Background: Congenital leptin deficiency (CLD) is an extremely rare condition due to homozygous pathogenic mutations in the leptin (LEP) gene. The clinical manifestation of patients with CLD is severe early-onset obesity and hyperphagia. Most patients with pathogenic homozygous leptin gene mutations have low or undetectable leptin levels, whereas few cases show high bio-inactive circulating leptin levels. To date, around 20 variants in the LEP gene have been d...

Objective: Obesity is a multifactorial genetic disorder. Monogenic obesity, explaining 5-13% of early-onset cases, is often associated with hyperphagia and reduced energy expenditure. Syndromic obesity involves additional clinical features such as developmental delay, hypogonadism, and sensorial hearing deficits. This study aims to enhance the understanding and management of patients with syndromic obesity by evaluating their anthropometric, laboratory, and cl...

Introduction: Children with obesity are at higher risk of asthma. It is known the relationship between asthma and obesity in children demonstrated by altered lung function in obese compared to normal weight children. However, few studies have evaluated changes in lung function in obese asthmatic patients undergoing therapy.Objective: The aimwas to evaluate the role of weight gain in the development of spirometry alterati...

Background: Bardet-Biedl syndrome (BBS) is a rare, autosomal recessive, clinically and genetically heterogeneous, pleiotropic disease characterized by the immotile primary cilia, leading to an MC4R pathway impairment. In addition to syndromic features, patients present with hyperphagia, early-onset obesity, metabolic syndrome (MetS) and increased risk of type 2 diabetes. Here, we aimto describe metabolic features and MetS z-score in a group of rare BBS cases.<...

Objective: To present the spectrum of monogenic obesity presenting to a tertiary children’s hospital in UAEIntroduction: Monogenic obesity is increasingly recognized as a cause of severe early-onset obesity. Monogenic obesity syndromes arise from single gene mutations affecting critical for regulation of body weight and energy balance. Children with monogenic obesity often experience severe, early-onset weight gain...

Background: Childhood obesity, defined as having a BMI ³95th percentile for age and gender, can have serious consequences, hence; new treatments are needed. Liraglutide, a glucagon-like peptide-1 hormone, is the first FDA-approved therapy for adolescents’ obesity in over a decade. This study aim ed to evaluate the efficacy of liraglutide for weight loss and other metabolic parameters in children with obesity in Saudi Arabia.<s...

Background: Childhood obesity remains a significant public health concern, with weight management programmes to date only showing limited success. This project aims to evaluate initial first year outcomes for our Complications of Excess Weight (CEW) Service based at our tertiary paediatric centre. Children and young people with significant obesity in our region and referred to the service, receive tier 3 weight management support, including intensive lifestyle...

Introduction: Heterozygous variants of the melanocortin-4 receptor gene (MC4R) are the most common cause of monogenic obesity. Until recently, patients with monogenic obesity often underwent a frustrating diagnostic and therapeutic odyssey of years of ineffective lifestyle interventions before a causal diagnosis was made. Data from case reports suggest that individuals with obesity caused by heterozygous MC4R pathogenic variants can be effect...

Background: Monogenic obesity (MO) is a rare form of obesity caused by mutations in a single gene, and characterized by being severe and with early onset. The leptin-melanocortin pathway is the main pathway controlling satiety and food intake. Genetic variants in this pathway have been implicated in MO with many being identified in consanguineous populations. Another group of neuronal proteins important in the development of neuronal circuits linked to energy ...

Introduction: Many genes have now been identified in which rare, high penetrant variants cause obesity, accounting for ~10% of children with severe obesity.Aim: To describe clinical characteristics, genetics, and associated comorbidities in pediatirc endogenous obesity due to rare genetic obesity syndromes.Methods: After excluding patients with obesity due to endocrine disturbances...

Objective: This study investigated the genetic etiology and clinical phenotype of non-syndromic childhood and adolescent obesity.Methods: A total of 392 non-syndromic obese children aged 7-14 years old who were hospitalized in Department of Endocrinology. Whole exon sequencing was used to screen the potential genetic causes and analyze CNV and 79 reported obesity candidate genes.Results:</s...