ESPE Abstracts

Background: Congenital Hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in newborns and children. In HI, the dysfunction of pancreatic beta-cells leads to excessive insulin production and severe hypoglycemia, which often causes irreversible neurological damage. The management of infants and children with HI is intensive, often requiring around-the-clock care and frequent visits to healthcare specialists, and places significant burden on...

Introduction: Diagnosing hypoglycemia-associated metabolic disorders is challenging and necessitates a methodical approach. Unlike idiopathic ketotic hypoglycemia (starvation hypoglycemia), fructose 1,6-bisphosphatase deficiency is an uncommon metabolic disorder characterized by a defect in gluconeogenesis. This disorder also causes lactic acidosis, hypertriglyceridemia, hyperuricemia, and ketonuria. This case report describes two siblings diagnosed with fruct...

Background and aims: Congenital hyperinsulinism (CHI) is a rare condition causing severe and recurrent hypoglycaemia in children. Feeding is a key aspect of glucose delivery; however, with severe illness causing nausea and frequent use of parenteral and non-oral feeding, infants with CHI often develop a range of feeding problems. Previous studies have shown persistence of feeding problems in this group but there is limited data on families’ experiences and per...

Background/aim: Congenital hyperinsulinism (CHI) is a group of genetic disorders characterized by impaired insulin secretion, resulting in recurrent hypoglycemia. CHI is the most common cause of severe and persistent hypoglycemia in infancy and childhood that is associated with an increased risk of seizures, developmental delay and permanent brain damage, with lifelong neurodisability if treatment is delayed. The incidence of CHI is estimated to be approximate...

Introduction: Octreotide is recommended as a second-line treatment for patients with congenital hyperinsulinism (CHI), particularly for those who do not respond to diazoxide orsurgical treatment. While the studies on the adverse effects ofoctreotide are still scarce in large cohorts.Methods: A retrospective study was conducted on CHIpatients who were treated with octreotide in the two largestcenters in China. The study c...

Background: Hypoglycemia in children is common but can indicate serious underlying conditions. Previous research has shown low rates of complete diagnostic evaluations for hypoglycemia in pediatric emergency rooms. This may be due to the complexity and time-consuming nature of the required workup and a lack of knowledge about the incidence of serious hypoglycemic disorders in children. This study aims to assess the effectiveness of an intervention to improve t...