ESPE2024 Free Communications Fat, Metabolism and Obesity 2 (6 abstracts)
Asprosin serum levels in subjects with Prader-Willi Syndrome: associations with hyperphagia, anthropometric, and metabolic parameters
Maria Felicia Faienza 1 , Mariangela Chiarito 1 , Alessia Aureli 2 , Raffaele Buganza 3 , Domenico Corica 4 , Maurizio Delvecchio 5 , Luisa De Sanctis 3 , Danilo Fintini 2 , Graziano Grugni 6 , Maria Rosaria Licenziati 7 , Simona Madeo 8 , Enza Mozzillo 9 , Irene Rutigliano 10 & Giuliana Valerio 11
1Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, Bari, Italy. 2Endocrinology and Diabetology Unit, Pediatric University Department, Bambino Gesù Children Hospital, IRCCS, Roma, Italy. 3Pediatric Endocrinology, Regina Margherita Children Hospital-Department of Public Health and Pediatric Sciences, University of Torino, Torino, Italy. 4Department of Human Pathology of Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy. 55Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L' Aquila, Italy. 6Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Verbania, Italy. 7Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy. 8Department of Medical and Surgical Sciences for Mother, Children and Adults, Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy. 9Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy. 10Pediatric Unit, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy. 11Department of Medical, Movement and Wellbeing Sciences. Parthenope University of Naples, Naples, Italy
Introduction: Asprosin is a new discovered adipokine involved in the regulation of appetite, glucose, and energy homeostasis. The aim of our study was to evaluate asprosin serum levels in children and adults affected with Prader-Willi Syndrome (PWS), and to compare with hyperphagia questionnaire (HFQ), anthropometric and metabolic parameters.
Methods: This cross-sectional study included 118 PWS subjects (88 children, mean age: 10.55 ± 4.20 years; 30 adults, mean age: 34.28 ± 10.24) and 53 normal weight children paired by gender and age. All subjects underwent anthropometric evaluation (weight SDS, height SDS, Body Mass Index-BMI SDS). Hyperphagia was assessed by the Italian version of the HFQ. Fasting levels of glucose, insulin, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were assessed. Homeostasis model assessment for insulin resistance (HOMA-IR) was determined. Asprosin serum levels were measured by ELISA (MyBioSource, USA).
Results: Among PWS children, 27 subjects (30.7%) were normal weight (NW), 24 subjects (27.3%) were overweight (OW) and 37 subjects (42%) were obese according to the Italian BMI normative curves. Among PWS adults, 3 subjects (10%) were NW, 4 subjects (13.4%) were OW and 23 subjects (76.6%) were obese according to the WHO criteria. A positive correlation between age and BMI was found both in adults (r: 0.442; P = 0.014) and in children (r: 0.302; P = 0.004). Asprosin levels were higher in PWS children compared to healthy controls (1.55 ± 0.70 ng/ml vs 1.33 ± 0.36 ng/ml, P = 0.004). In PWS children, asprosin levels were higher in OB than NW subjects (r: 0.252; P = 0.018). No significant differences were found according to sex and pubertal stage. Fasting asprosin concentrations were higher in PWS adults compared to PWS children (1.70 ± 0.37 ng/ml vs 1.55 ± 0.70 ng/ml, P = 0.026). No association was demonstrated between asprosin levels and hyperphagia score or fasting glucose, insulin, HOMA-IR, lipid profile either in children or in adults.
Conclusion: Our results showed an association between weight status and asprosin levels in PWS patients, while they do not support the role of this adipokine in the disrupted regulation of hunger in our cohort of patients. Future researches are needed to further explain the role of this adipokine in the regulation of the metabolism in obese PWS.
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