ESPE2024 Free Communications Pituitary, Neuroendocrinology and Puberty 1 (6 abstracts)
Screening for First Morning Voided (FMV) Urinary Gonadotropin (Gn) in Children with Normal and Precocious Puberty (PP): A Prospective, Multi-Center, Large-Sample based Study in China
Feng Ye 1 , Ruimin Chen 2 , Yu Yang 3 , Dongguang Zhang 3 , Zhiya Dong 4 , Wenli Lu 4 , Min Zhu 5 , Xinran Cheng 6 , Peng Gou 6 , Huamei Ma 7 , Qiuli Chen 7 , Guoqing Dong 8 , Chunxiu Gong 9 , Feihong Luo 10 & Xiaoping Luo 1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. 2Fuzhou Children's Hospital of Fujian Province, Fuzhou, China. 3Jiangxi Province Children's Hospital, Nanchang, China. 4Ruijin Hospital, Shanghai Jiao Tong University Medical School, Shanghai, China. 5Children's Hospital of Chongqing Medical University, Chongqing, China. 6The Affiliated Women's and Children's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 7First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. 8Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, China. 9Beijing Children's Hospital, Capital Medical University, Beijing, China. 10Children's Hospital of Fudan University, Shanghai, China.
Background: Clinical use of serum gonadotropins (Gn) test for diagnosis of pubertal disorders is always limited by invasive sampling, requirement of hospital visit, high expense and the feature of pulsatile secretion of Gn. As an alternative, evaluating first morning voided (FMV) urinary Gn (U-Gn) may facilitate non-invasive pubertal assessment.
Objective: In this study, we will explore whether FMV U-Gn can predict the activation of HPGA, and find out the reasonable cut-off value for CPP screening, diagnosis and follow-up through a large-sample, multi-center prospective study in China.
Patients and Methods: This prospective was conducted across 10 centers in China and consisted of two cohorts. For 7,386 healthy participants in Cohort 1, they were measured the levels of FMV U-Gn to identify the influence factor of U-Gn and to determine its cut-off value for Tanner staging. For 340 children with PP in Cohort 2, they were evaluated the levels of FMV U-Gn, basal and peak S-Gn after GnRH stimulation test (GnRHST) to explore the diagnosis and follow-up value of the former.
Results: In Cohort 1, multivariate linear regression analyses revealed that the level of U-Gn was significantly associated with age, parental height, target height and Tanner stage (P <0.05). Moreover, ROC analysis was conducted to estimate the value of FMV U-Gn in classifying Tanner 1 and T2-T5 stages. The optimal cut-off values of U-FSH, U-LH and U-LH/U-FSH for T1/T2-T5 staging were 5.87 mIU/mL, 1.15 mIU/mL and 0.20, with the sensitivity of 64.32%, 80.99% and 77.99%, and the specificity of 67.64%, 67.48% and 62.90%, respectively. In Cohort 2, U-LH was strongly correlated with peak S-LH (r =0.315, P <0.001) after GnRHST. The U-Gn levels of children with positive GnRHST result were significantly higher than those with negatives (P <0.001). The best cut-off values of U-LH, U-FSH for predicting a positive GnRHST result were 1.85 IU/L and 8.17 IU/L, with their sensitivity of 70.3% and 63.4%, and specificity of 83.6% and 63.8%, respectively. For a total of 706 follow-up visitis, 81.1% (524/646) from girl and 63.3% (38/60) from boy were in an inhibitory state, when blood LH<0.6 IU/L was used as the inhibition standard and Youden index as the optimal cut-off value. The specificity was 79.2% and 93.8%, respectively when using U-LH 0.405 IU/L and LH/FSH 0.082 as the inhibition standard.
Conclusion: FMV U-Gn performed well in classifying Tanner stage in healthy children, and predicting GnRHST result in children with PP, as well as inhibition standard for treated patients. It’s a good indicator in the screening, diagnosis, and follow-up of PP.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more