ESPE2024 Poster Category 1 Bone, Growth Plate and Mineral Metabolism 1 (11 abstracts)
Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner stage-matched Sex Hormone Level May be an Early Interpreter of Pediatric Bone Fragility
Sung Eun Kim , Seul Ki Kim , Shin Hee Kim , Won Kyoung Cho , Kyoung Soon Cho , Min Ho Jung & Moon Bae Ahn
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea
This study aimed to investigate the impact of hypogonadism on bone mineral density (BMD) in children and adolescents with chronic diseases to determine the relationship between sex hormones and BMD. Information of children and adolescents with chronic diseases, such as haemato-oncologic, rheumatoid, gastrointestinal, and endocrinologic diseases, was retrospectively collected. Relationship between sex- and Tanner stage-matched z-scores for sex hormones and sex- and age-matched lumbar spine BMD (LSBMD) z-scores were evaluated. Adjustments were made for confounders such as underlying diseases, age at diagnosis, and age- and sex-matched body mass index z-scores. A total of 672 patients were included in this study and their mean LSBMD z-score was −0.55±1.31. In multivariate regression analysis, male testosterone showed positive association with LSBMD z-score (P <0.001), whereas female estradiol, luteinizing hormone, and follicular stimulating hormone showed no significant association with LSBMD z-scores. In male group, testosterone level was associated with LSBMD z-scores >-1.0 (P <0.001), >-2.0 (P <0.001) and >-3.0 (P = 0.002), while estradiol level was associated with LSBMD z-scores >-2.0 (P = 0.001) and >-3.0 (P = 0.002) in female group. Sex hormones showed positive correlation with BMD in children and adolescents with chronic diseases. Therefore, various measures may be necessary to predict future skeletal problems and improve bone health in these patients.
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