ESPE Abstracts

Introduction: Growth Hormone Deficiency (GHD) in early childhood is a significant concern due to its impact on physical development. This retrospective study investigates the early growth patterns of children diagnosed with GHD during early childhood (average diagnosis age 5.2 years ± 1.1 years) to understand the progression of growth deviations in this population.

Patients and Methods: Our study involved a retrospective review of medical records for children diagnosed with GHD. The cohort consisted of children with an average age of diagnosis at 5.2 years, with a standard deviation of 1.1 years. We analyzed their Length and Weight Standard Deviation Scores (LTSDS and WTSDS, respectively) at various time points from birth to 48 months. Data included mean, mean ± standard error (SE), and comparison with WHO standards for length. The Mid-Parental Height Standard Deviation Score (MPhTSDS) was also considered to examine potential genetic influences on growth patterns.

Results: The study revealed a consistent negative trend in LTSDS and WTSDS, starting from birth and continuing through to 48 months. The mean LTSDS at birth was -1.09, decreasing sharply to -2.64 by 2 months, and remaining below -2 throughout the first four years. Similarly, the mean WTSDS showed a notable deficiency, with the lowest score at 24 months (-1.71). The comparison with WHO standards highlighted a consistent lag in growth, with the gap widening over time.

Discussion: The data clearly indicates a significant and persistent deviation from typical growth patterns in children with GHD from an early age. The rapid decline in growth scores in the first few months post-birth underscores the impact of GHD on early developmental stages. These findings are consistent with existing literature, emphasizing the importance of early diagnosis and intervention in managing GHD.

Conclusion: This retrospective study underscores the profound impact of GHD on early growth, evident from a very young age. The consistency in negative growth deviation highlights the need for heightened awareness and early screening for GHD in children showing signs of delayed growth. Timely intervention and management are crucial in improving growth outcomes for children with GHD, aligning with the goal of achieving growth patterns closer to typical developmental standards.