ESPE Abstracts

Background: MiniMed™ 780G was launched in Japan in November 2023 and is expected to further improve glycemic control.

Objectives and Methods: 】Subjects of this study were 29 patients with T1DM, aged 2-18 years (average 8.8 years old), who have been treated by SAP using MiniMed™ 770G for at least 3 months prior to switching to 780G smart guard system. We divided subjects into 2 groups by HbA1c levels over or less than 7% before 780G treatment (group H; n = 16, HbA1c 7.0~8.2％, group L; n = 13, HbA1c 6.1~6.9％). We investigated changes in HbA1c levels and TIR, TITR, TAR and TBR at baseline (right before switching: period 0 (P0)), 4, 8, 12 weeks after switching (PI, II, III, respectively). Statistical analysis was performed using Friedman test and Bonferroni method as a post-test and Mann-Whitney U test to compare the data from 2 groups.

Results: The mean sensor use rate was 95, 97, 96, 96% at P0, I, II, III, respectively. Overall, HbA1c significantly decreased from P0 to II, III, and from PI and II, III (7.0→6.9→6.6→6.4%). TIR was changed during P0 to PIII as 74→77→77→77%, TITR 54→57→57→58%, TAR 20→18→17→18%, and TBR 4→5→5→5%, but all of these changes were not statistically significant. The subjects with group H had a higher pre-transition TAR than the group L at P0, whereas there were no significant differences in TIR, TITR, and TBR between 2 groups. In the group H, HbA1c significantly decreased (7.3→7.05→6.6→6.6%), at PII. TAR significantly decreased (23.5→19.5→18.5→18.5%) and TITR significantly increased (52→59.5→58.5→57%) at PII, when compared to P0. However, TBR also significantly increased (4→6→6.5→5.5%) at PII. On the other hand, in the group L, we observed improvement in TIR, TITR, TAR, and TBR although these changes were not significant, HbA1c also decreased (6.6→6.5→6.4→6.3%).

Discussion and Conclusion: SAP treatment with 780G pump is well-accepted and tolerated in Japanese children and adolescents with T1DM. Most of the DM control measures showed improvement during 3 months observation period, especially for those with higher HbA1c on 770G. The increase in TBR was also observed in higher HbA1c group, which should be further improved.