ESPE2024 Poster Category 3 Growth and Syndromes (34 abstracts)
Accuracy of the Algerian Growth Chart in diagnosing growth hormone deficiency
Adel Djermane 1,2 , Yamina Ouarezki 1,2 , Asmahane Ladjouze 1 , Sakina Kherra 1 , Kahina Mohammedi 1 , Meriam Bensalah 1 & Hachemi Maouche 1
1Algiers University 1, Algiers, Algeria. 2Public Hospital, El Harrach, Algeria
Introduction: Short stature is the one of the most common referral to paediatric endocrine clinic. Analysis of growth charts is a non-invasive tool and should allow differentiation between normal and abnormal growth. The aimof thid study is to compare the accuracy of Algerian growth charts (DZ-charts) with WHO growth charts in identifying short stature.
Method: Measurement of children and adolescents aged from 6 to 14 years old who presented to paediatric endocrine clinic between January 2015 and December 2022 for short stature were analyzed. Anthropometric parameters were reviewed and converted to Z score using WHO Anthroplus software, and macros derived from DZ-Chart 2007. Children with height Z -score less than -2 SDS according to WHO criteria were investigated for short stature as per institutional protocol. Growth hormone deficiency was defined as either two abnormal stimulation tests (peak GH<7ng/ml) or one abnormal test with an abnormal pituitary MRI.
Result: During the study period, records of 413 children were collected. The proportion of all children identified by screening as at risk of pathological short stature <-2SDS was the same with OMS (47.79%) and the DZ -Chart (48.06%) growth charts. We find a strong correlation between the DZ-Chart an WHO Chart r =0.967. The Bland-Altman plot show no difference between the two method.
| Taille SDS | WHO | DZ-Chart | p |
| Girl, n = 158 | -2.75±0.86 | -2.81±1.02 | 0,581 |
| Male, n = 255 | -2.72±0.7 | -2.78±0.75 | 0,316 |
| Global: | -2.73±0.76 | -2.79±0.86 | 0,272 |
| <-2 | 368 (89.1) |
363 (87.89) |
0.586 |
| <-3 | 116 (28.1) |
133 (32.2) |
0.198 |
| GHD, n = 190 | -2.9±0.94 | -2.98±1.06 | 0.430 |
| ISS, n = 223 | -2.58±0.53 | -2.63±0.61 | 0.394 |
Conclusion: Our observations suggest an equal accuracy of DZ-Chart 2007 and WHO growth charts in identifying pathological short stature and Growth Hormone Deficiency.
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