ESPE Abstracts

Type I diabetes mellitus (DM) is one of the most common childhood chronic diseases. Early signs of diabetogenic cardiomyopathy, which appears as a complication of autonomic diabetic neuropathy in children, have not been sufficiently studied. The purpose of the work: the study of the electrical stability of the myocardium based on the analysis of the QT interval in the ECG in children with DM type 1.

Material and Methods: 82 children with type 1 DM were included in the examination. The age group of 6-11 (n = 38), and the age group of 12-17 (n = 44) are divided into 2 subgroups according to the duration of DM: 0-3 years (1A, 1B) 4 years and more (2A, 2B). 40 practically healthy children were included in the control group. In order to study the changes in the homogeneity of the bioelectric activity of the myocardium, the QTmax, QT min, QTmid and dQT, QT max, QT min, QTmid and dQT, the previous RR interval of the duration of the QT interval in both unipolar (aVR, aVL, aVF, V1-V6) and I, II, III standard leads. Along with these indicators, indices of the QT interval such as dQTmax, QTcmin, QTcmax, dQTc, dQTcmax were determined.

Results: the changes occurred depending on the age of the children and at the same time the duration of diabetes. The results of the patients included in subgroup I A of the 6-11 age group (follow-up period 0-3 years), the changes in the studied indicators of the QT interval compared to the control group, other indices except QTcmax were characterized as not statistically significant (P >0.05). In the subgroups of children with DM type 1 aged 6-11 years, divided by the duration of diabetes, these indicators increased significantly in children with duration of DM of 4 years or more. When analyzing the indicators of the QT interval in the 2B group of children aged 12-17 years, QT, QTc, QTmax, QTmin, Qtmax, Qtcmin were significantly different compared to the control group (P˂0.05). A similar change of QTcmax and QTcmin of the QT interval was observed between subgroups according to duration and between groups 1B and 2B.

Conclusion: Based on the received data, in children with DM type 1, the variability of the dispersion indicators depending on the age and duration of diabetes can be evaluated as a factor determining the changes of the homogeneity of the bioelectric activity of the myocardium.