ESPE Abstracts

Objectives: The metabolic condition beginning in childhood may increase the risk of premature death from cardiovascular disorders, which are the most common causes of death in the adult population. It is beneficial to diagnose and treat obesity in children because therapeutic intervention can prolong life and put off cardiovascular complications. The aimof the study is analyze of IGF1 and other biochemical factors in obese children and comparison to children with pure glycemic disorder (diabetes mellitus type 1- DM1) and without glycemic disorders.

Methods: The observational study examined 139 patients, aged 2.6 to 18 years, divided into 3 groups: DM1 (52 subjects), obesity (60 subjects), control (27 healthy subjects). In all children were calculated BMI, and assayed cholesterol, LDL, HDL, triglycerides, fasting glucose, glucose and insulin in oral glucose tolerance test, blood pressure and IGF-1.

Results: Children with obesity developed elevated triglycerides compared to children with type 1 diabetes and a control group in whom no such pathology was observed. Triglycerides are higher in obesity (mean 301.8 ± 1433.2 mg/dl) than in diabetes (mean 140 ± 130.8 mg/dl) than in controls (mean 94.7 ± 46.1 mg/dl). Moreover, IGF-1 levels are significantly elevated in obesity, which can accelerate the onset of its complications. IGF -1 serum levels in obesity are higher (mean 234 ± 138.0 nmol/L) than in diabetes type 1 (mean 99.0 ± 62.3 nmol/L) and controls (mean 185.7 ± 103.0 nmol/L).

Conclusion: Childhood obesity can already predicate elevated serum triglycerides and elevated IGF1 as an early factor encouraging deeper diagnostics and early treatment intervention.