hrp0098p1-145 | Fat, Metabolism and Obesity 3 | ESPE2024

Food deserts and deprivation: Experience from a Complications of Excess Weight Service in UK

Chen Lee Shien , A Oyeniyi Juliana , Papanikolaou Theodora , Say Sarah , Duggal Kiran , Davies Tracie , Ravat Safia , Jones Natalie , Uday Suma , Idkowiak Jan , P Dias Renuka

Introduction: West Midlands Complications of Excess Weight (CEW) service covers a large geographical area with high levels of ethnic diversity with over 40% of people living in the most deprived decile (Index of Multiple Deprivation -IMD). We aim to investigate markers of deprivation in our CEW cohort.Methods: Retrospective review of patients seen in our CEW service between July 2021 and August 2023. Data was collected f...

hrp0095p1-447 | Diabetes and Insulin | ESPE2022

Access and use of new technologies in diabetes care in patients that need an Interpreter compared to those that do not

Ayya Mekhala , Chizo Agwu Juliana

Young people with Type 1 Diabetes Mellitus encounter daily struggles with titrating insulin to achieve adequate glycemic control. Technology is improving with insulin pumps and continuous glucose monitoring (CGM) however access to it remains variable across the UK. Those from ethnic minorities and deprived areas are less likely to access technology and more susceptible to developing complications of diabetes with worsening HbA1c’s. Understanding the reasons for health in...

hrp0092p2-210 | Multisystem Endocrine Disorders | ESPE2019

Autoimmune Thyroiditis and Autoimmune Hepatitis Presenting at Onset of Type 1 Diabetes (T1D)

Marchant Alice , Chizo Agwu Juliana

Background: Autoimmune disease (AD) occurs due to loss of immunological tolerance to self-antigens and can be organ specific or systemic. One in four patients with a single AD may develop another AD. The presence of three or more AD is described as multiple autoimmune syndrome (MAS) in which Type 3 subset includes autoimmune thyroiditis and T1D, but not autoimmune hepatitis. Type 2 Autoimmune Polyendocrine Syndrome can be diagnosed when T1D and autoimmune thyr...

hrp0086p1-p363 | Gonads & DSD P1 | ESPE2016

Mosaic Xq Partial Duplication Leading to Virilisation of an Adolescent Female

Baranowski Elizabeth , Chizo Agwu Juliana

Background: We present a 17-year-old female who presented with a 1 year history of hirsutism, male pattern baldness, marked cystic acne and mild cliteromegaly. She had her menarche at the age of 15 years and continued thereon to have a regular menstrual cycle. She was pubertal on examination (B3, P5, A5) with no neurological deficit.Objective and hypotheses: This female presented with marked clinical hyperandrogenism. We initially suspected polycystic ov...

hrp0092p2-76 | Diabetes and Insulin | ESPE2019

Coexistence of Medium chain acyl-CoA dehydrogenase deficiency (MCADD) and Type 1 diabetes (T1D): A management challenge

Afreh-Mensah Donald , Agwu Juliana C.

Background: Medium chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive fatty acid β-oxidation defect. The enzyme is important in the breakdown of medium chain fats into acetyl-CoA to produce ketones, alternative energy source when glucose hepatic glycogen stores become depleted during prolonged fasting. In MCADD, during periods of fasting/ acute illness, there are insufficient ketones to compensate for the glucose energy deficit, ...

hrp0092p2-18 | Adrenals and HPA Axis | ESPE2019

A Rare Case of Pseudohypoaldosteronism in a Neonate Secondary to Congenital Hydrometrocolpos

Kumar Shruti , McDermott Helen , Kamupira Sheilah , Chizo Agwu Juliana

Background: Hydrometrocolpos is a condition resulting in distension of the vagina and uterus due to accumulation of secretions (other than blood), caused by increased oestrogenic stimulation and vaginal outflow obstruction. The incidence in term neonates is 0.00014-0.001%. The condition presents at extremes of childhood, at birth when maternal circulating hormones are raised and at menarche when oestrogen production commences. Pseudohypoaldosteronism (PHA)...

hrp0089p3-p345 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

The Positive Effect of the Low-Dose Contraceptive on the Course of Cystic Fibrosis in the Adolescent Female

Ferenczova Juliana , Feketeova Anna , Urbanova Veronika , Vargova Veronika

Background: In female patients with cystic fibrosis (CF), female sex predisposes to the progression and worsening of lung function, which increases the incidence of acute exacerbations, and leads to the earlier bacterial colonization of Pseudomonas aeruginosa. The negative effect of estrogens on the clinical course of CF in girls begins to manifest with the onset of puberty and the appearance of secondary sexual characteristics. On the cellular-level estrogens affect: 1.) immu...

hrp0086p1-p206 | Diabetes P1 | ESPE2016

When to Screen for Coeliac Disease in Children with Type 1 Diabetes Mellitus: The Controversy

Ajanaku Ayo , Gorst Thomas , Ajanaku Deji , Chizo Agwu Juliana

Background: Routine screening for Coeliac disease (CD) beyond the first year of diagnosis with Type 1 Diabetes Mellitus (T1DM) is controversial due to a paucity of high-quality evidence. The UK guidelines (NICE) only recommend screening at diagnosis with T1DM or if subsequently symptomatic; whereas the International Society for Paediatric and Adolescent Diabetes (ISPAD) recommends routine screening every 1 to 2 years.Objective and hypotheses: We hypothes...

hrp0084p2-203 | Adrenals | ESPE2015

Autoimmune Encephalitis – A Newly Recognised Clinical Manifestation of Autoimmune Polyendocrine Syndrome Type 1?

Ferenczova Juliana , Vargova Veronika , Krysl David , Banoova Erika , Sadova Eva

Background: Autoimmune polyendocrine syndrome (APS) type 1 is a rare autosomal recessive disease. The classic features are chronic mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. Several non-classic presentations of the disease has been described over the last few years. Authors present a case of 14-year old girl with a new serious non-classic presentation.Case presentation: Patient was diagnosed with a mucocutaneous candidiasis...

hrp0089p2-p195 | Fetal, Neonatal Endocrinology and Metabolism P2 | ESPE2018

The Benefit of Universal Neonatal Screening for Hypoglycemia

Nicolas Georges , chaaban Riham , faddous-Khalifeh Marie-Claude , Souaiby Juliana , Salemeh Yara

Introduction: Hypoglycemia is a common problem in neonatal period associated with adverse neurological outcome and brain injury if treatment was not provided. AAP and PES recommended screening for hypoglycemia only in newborns with risk factors but many others neonates may present episodes of asymptomatic hypoglycemia without any known risk factor.Objectives: To assess the incidence of hypoglycemia in healthy full term neonates without any risk factors i...