ESPE Abstracts

Background: In Sub-Saharan Africa the prognosis of children with type 1 diabetes is poor. Many are not diagnosed and those diagnosed have a dramatically reduced life expectancy (<1 year).Objective and hypotheses: To identify the predictors of outcome in children and adolescents with type 1 diabetes.Method: A cross sectional study involving 76 children/adolescents (35 boys and 41 girls, mean age of 15.1±3.1 years) with type...

Background: Secretion of catecholamines by adipose tissue M2 macrophages was recently proposed as a molecular mechanism leading to activation of brown adipose tissue and heat generation in mice. However, published data are conflicting and it is not clear whether this pathway might play a role in humans. To shed light on this, we studied macrophage polarization in human white and brown adipose tissue and related it to thermogenic gene expression.Methods: ...

Introduction: Physical growth according to genetic potential is a hallmark of childhood health [1]. Childhood growth is complex and the physiological processes involved in promoting healthy growth are not fully understood, including the gut microbiota. The gut microbiota matures from birth towards adulthood, and this process might be affected by several factors, including mode of delivery, food intake and antibiotic treatment. The bacterial gut microbiota is observed to be mor...

Objectives: Current safety data do not indicate an association of GH therapy with increased risk for development/progression of tumours, or worsening of congenital cardiac conditions in individuals with Noonan syndrome (NS); however, data are limited. This report describes real-world safety data on GH therapy in paediatric patients with NS.Methods: Two complementary non-interventional, multicentre studies, NordiNet IOS (NCT00960128) and ANSWER Program (N...

Background: Anthropometry is the general tool for defining overweight and obesity, with BMI cut-offs adjusted for sex and age, as the most commonly used variable in childhood.Objective and hypotheses: Based on the interrelationships between BMI and different overweight-related anthropometric variables we wanted to find out which anthropometric variables contribute most to the variation in BMI, and how age affect this picture?Method...

Aim: Data on weight status are essential to guide the development of preventive measures, which can reduce adverse consequences for health. The aim of this study was to estimate trends, from 2010 to 2022, in the prevalence of overweight, obesity and severe obesity, using the International Obesity Task Force cut-off values. Weight trends were explored in children between 2 and 14 years in the municipality of Bergen, Norway.Methods...

Background and aim: Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals found in everyday consumer products. These chemicals are considered endocrine disruptive. However, their effect on pubertal onset and development is still unclear. The aim of the current study was therefore to explore the relationship between PFAS exposure and pubertal development using novel objective pubertal phenotyping, e.g., ultrasound-determined testicular v...