ESPE Abstracts

Background: Early onset of androgen excess in pre-pubertal children is usually caused by called premature adrenarche (PA). PA is characterised by the development of pubic and axillary hair, adult-type body odour in girls <8yrs and in boys <9yrs. PA may be a forerunner condition of polycystic ovary syndrome (PCOS), a complex metabolic disorder also characterised by androgen excess. Women with PCOS have higher risk of developing type 2 diabetes, dyslipidae...

Introduction: Early-onset androgen excess commonly presents in pre-pubertal girls as premature adrenarche (PA). Girls with PA have clinical signs of androgen excess, such as pubic/axillary hair, body odour, greasy hair, and moderately elevated adrenal androgens before their 8th birthday. There is conflicting evidence if girls with PA are at higher risk to have or develop metabolic dysfunction, or progress to developing Polycystic Ovary Syndrome (PCO...

Introduction:Thyroid hormones are essential for early neurocognitive development as well as growth and development throughout childhood. The intelligence of children with dysthyroidism has been little evaluated.Objective:Assessing of the intelligence in children with dysthyroidism.Patients and methods: Descriptive prospective study carried out by applying the IQ in 26 patients aged...

Background: Type1 diabetes mellitus is increasing worldwide in childhood. Education is an essential part of the package care at diagnosis. It adresses children with newly diagnosed type 1 diabetes and their families and is made by young doctors and paramedical staff (nurses and nutritionnists).Objective: to assess the knowledge of the medical and paramedical staff concerning the global management of type 1 diabetes in ch...

Background: Prevelance of type 1 Diabetes Mellitus is increasing world wide and it is associated with multiple factors.Objective and hypotheses: We aimed to evaluate the clinical and laboratory characteristics of patients with type 1 DM.Method: Clinical records of 184 patients with diabetes (0–18 years) admitted between January 2010 and January 2014 were analysed retrospectively. Age and season at admission, type of admission,...

Introduction: X-linked ichthyosis is an inherited disorder of keratinization due to steroid sulfatase deficiency. It may be part of a contiguous gene syndrome characterized by the presence of several clinical features including hypogonadism, Leri-Weill syndrome, short stature, chondrodysplasia punctata, mental retardation, epilepsy, Dandy-Walker malformation and ocular albinism. It is due to microdeletions of Xp22.3. We report observations of two siblings with syndromic x-link...

Introduction:Subclinical hypothyroidism (SH) is defined in children by a moderate rise in TSH (TSH: 4.5-10 mU/l) compared to a normal level of free T4. However, the clinical consequences remain a subject of controversy, hence the need to take a position on the relevance of treating it.Objective: Description of the clinical, biological and evolutionary characteristics of SH in children.Patie...

Annotation: Pandemics of coronoviral infection continues affecting the wold community, and with the comprehension of its pathological physiology an interest in endocrine effects ofSARS-CoV-2 grows too. It was determined, that the main target organs affected by SARS-CoV-2 were lungs and immune system, while it is still not clear if SARS-CoV-2 has any impact on the thyroid function. In patients infected with SARS-CoV, coronovirus relevant to SARS-CoV-2, damage o...

Background: Devices for continuous subcutaneous insulin infusion have become fundamentally new and progressive step in the treatment of diabetes.Aims and objectives: To evaluate the effectiveness of insulin pump therapy in comparison with the regime of multiple daily injections (MDI) of insulin.Materials and Methods: Forty children and adolescents with type 1 diabetes from 5 to 17 ...

Bardet-Biedl syndrome (BBS) is a multiorgan genetic disease which is a part of ciliopathies. The HAS (Haute Autorité de santé) published in March 2019 a new National Diagnostic and Care Protocol for Bardet Biedl syndrome. However, in practice, we face the difficulties of screening and multidisciplinary care of different complications.We report our experience with siblings composed of an eight-year-old boy and an 18-month-old girl suffering from...