hrp0098p2-26 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Bisphosphonate Therapy in a Pediatric Case Series with Monostotic Form of Fibrous Dysplasia: A Single-Center Retrospective Analysis of Efficacy and Safety

Ilic Nikola , Cvetkovic Dimitrije , Paunovic Zoran , Bogosavljevic Marko , Krstic Jovana , Todorovic Sladjana , Sarajlija Adrijan

Background: Fibrous dysplasia (FD) is a rare bone disorder characterized by the proliferation of fibrous tissue within the bone, leading to pain, deformity, and an increased fracture risk. While management primarily focuses on symptomatic relief, surgical interventions, calcium supplementation, and vitamin D therapy, bisphosphonates have been used as a therapeutic option in children. However, studies of bisphosphonate efficiency have shown inconclusive results...

hrp0098p3-101 | Fat, Metabolism and Obesity | ESPE2024

Correlation of body mass index and insulin resistance in obese and overweight children and adolescents - a single center study

Jakovljevic Milica , Stojkovic Milica , Cvetkovic Vesna , Stankovic Sandra

Introduction: According to World Health Organization, in 2022 over 429 millions of children were obese. Insulin resistance is a resistance to the effects of insulin on glucose metabolism and measured by Homeostasis model assessment- Insulin resistance index (HOMA-IR). Previous studies suggested a correlation between body mass index (BMI) for age and sex with HOMA IR and advised using BMI as a surrogate marker for insulin resistance.<stro...

hrp0098p3-263 | Thyroid | ESPE2024

Urinary iodine concentrations in schoolchildren in Serbia: still too little or too much

Saranac Ljiljana , Cvetkovic Vesna , Jakovljevic Milica , Novak Marin

Background: Iodine plays a priviledged role in the human body, allowing thyroid hormones syntesis, necessarry for appropriate energy levels for an active life. In children it plays role in early brain development and somatic growth, bone and pubertal maturation. The overall picture of iodine supply and eradication of Iodine Deficiency Disorders (IDD) is still cause of concern. The iodine status of regions is assessed by median urinary iodine concentrations (UI...

hrp0097p1-304 | GH and IGFs | ESPE2023

Prevalence and predictors for growth hormone deficiency in children born small for gestational age with short stature

Cvetković Dimitrije , Milenković Tatjana , Todorović Slađana , Mitrović Katarina , Vuković Rade , Panić Zarić Sanja , Čehić Maja

Introduction: Small for gestational age (SGA) is a common condition affecting around 10% of all newborns, and it is associated with an increased risk of short stature and other health problems later in life. Growth hormone deficiency (GHD) is a well-known cause of growth failure in children, and it is estimated to affect approximately 1 in 4.000-10.000 children. However, the prevalence of GHD in SGA children with short stature is not well established. Early de...

hrp0084p3-1126 | Pituitary | ESPE2015

Outstanding Growth Response to Growth Hormone Replacement Therapy in 3 Different Cases of Growth Hormone Deficiency

Saranac Ljiljana , Djuric Zlatko , Markovic Ivana , Stamenkovic Hristina , Lazarevic Dragoljub , Cvetkovic Vesna

Background: Growth response in growth hormone deficient children during growth hormone (GH) replacement therapy rarely fulfil our projections and patientÂ’s expectations. We here report 3 cases with outstanding growth response.Case reports: First patient was diagnosed as gluten enteropathy in early childhood, but the diet did not improve his growth. At age of 7 years the diagnosis of isolated growth hormone deficiency (GHD) was established and GH sub...

hrp0097p2-203 | Adrenals and HPA Axis | ESPE2023

A male infant with X- linked congenital adrenal hypoplasia and Xp 21 contiguous gene deletion syndrome- case report

Stojkovic Milica , Markovic Aleksandar , Golubovic Milan , Ognjanovic Andjela , Andrejevic Marija , Jakovljevic Milica , Cvetkovic Vesna , Stankovic Sandra

Background: The Xp21 contiguous gen deletion syndrome is a rare disorder which is characterized by complex glycerol kinase deficiency, congenital adrenal hypoplasia, intellectual disability and Duchenne muscular dystrophy. It is caused by partial deletion of Xp 21. On Xp21 several genes are located contiguously, such as NR0B1/DAX1, dystrofin gen and gene for glycerol kinase, and the clinical features depend on the size of the deletion. The major clinical manif...

hrp0098p2-150 | GH and IGFs | ESPE2024

Real-world data on growth hormone therapy adherence using a connected injection device and catch-up growth in children with growth disorders in Serbia

Zdravkovic Vera , Vorgucin Ivana , Stankovic Sandra , Milenkovic Tatjana , Cvetkovic Zoran , Koledova Ekaterina , van Dommelen Paula

Background: Recombinant human growth hormone (r-hGH) therapy is an effective treatment strategy for children experiencing growth disorders. However, poor adherence to long-term r-hGH therapy can lead to suboptimal catch-up growth. Digital health solutions, such as easypod® connect ecosystem, can facilitate adherence to r-hGH therapy in these patients.Aim: To investigate the adherence to r-hGH therapy administered via...

hrp0098p3-348 | Late Breaking | ESPE2024

A phenotipically female child with Deletion 9p Terminal Syndrome with Sexual Development Disorder - case report

Ignjatovic Milica , Cvetkovic Vesna , Stankovic Sandra , Jakovljevic Milica , Andrejevic Marija , Stankovic Tatjana

Background: Deletions of distal chromosome 9p24 are often associated with 46,XY gonadal dysgenesis and, depending on the extent of the deletion, the monosomy 9p syndrome. The phenotype shows variable expressivity and is related to the size of the deletion. XY sex reversal is a relatively rare type of DSD (disorder of sexual development). Terminal region of short arm chromosome 9p (9p24.3 region) contains 3 types of DMRT genes (DMRT1-3). DMRT1 gen acts in syner...

hrp0086p1-p241 | Diabetes P1 | ESPE2016

Renal Functional Reserve in Children with Type 1 Diabetes

Zdravkovic Vera , Sajic Silvija , Stefanovic Darija , Jesic Maja , Cvetkovic Mirjana , Kostic Mirjana , Paripovic Dusan , Bojic Vladislav , Antic Amira Peco

Background: Early detection of diabetic nephropathy is of great importance. Renal functional reserve (RFR) is the difference between glomerular filtration rate (GFR) in basal conditions and GFR after a protein meal.Objective: To examine renal functional reserve in children with type 1 diabetes mellitus (T1D) in order to detect diabetic nephropathy at early stage.Method: Case control study included patient...

hrp0095p1-398 | Thyroid | ESPE2022

Unusually Enlarged Ovaries Associated with Severe Hypothyroidism - Van Wyk and Grumbach Syndrome Case Report

Cvetković Dimitrije , Todorović Slađana , Milenković Tatjana , Mitrović Katarina , Vuković Rade , Panić Zarić Sanja , Savić Đorđe , Mijović Tanja , Smolović Dijana , Tončev Jovana

Introduction: Since 1960, enlarged polycystic ovaries associated with hypothyroidism, delayed bone age and precocious puberty are recognized as Van Wyk and Grumbach syndrome. Although it is rare entity, it should be considered in differential diagnosis of the enlarged polycystic ovaries.Case: An eleven-year-old girl was presented with sudden onset of abdominal pain and vomiting. A large mass with multiple cysts was seen ...