hrp0098p3-81 | Diabetes and Insulin | ESPE2024

A Case of Stress Hyperglycaemia with Ketoacidosis – Diagnostic Dilemma

Flynn Evelyn , Burke Eleanor , McGrath Niamh

Introduction: Non-diabetic ketoacidosis occurring with hyperglycaemia causes diagnostic dilemma in the emergency department. Biochemistry mimics diabetic ketoacidosis [DKA], the proposed mechanism is ketosis from reduced carbohydrate intake, with stress hyperglycaemia from acute illness.Case Description: A 1 year old boy presented to the emergency department with a short history of fever and reduced oral intake. Initial ...

hrp0082fc4.4 | Growth | ESPE2014

Short Stature, Accelerated Bone Maturation, and Early Growth Cessation due to Heterozygous Aggrecan Mutations

Nilsson Ola , Guo Michael , Dunbar Nancy , Popovic Jadranka , Flynn Daniel , Jacobsen Christina , Lui Julian , Hirschhorn Joel , Baron Jeffrey , Dauber Andrew

Background: Most children with idiopathic short stature (ISS) have a delayed bone age (BA). ISS with advanced BA is far less common. We studied three families with autosomal dominant short stature, unexplained BA acceleration, and premature growth cessation.Objective and hypotheses: To identify the genetic cause of this condition and describe its clinical spectrum.Method: Whole exome sequencing was performed in selected individuals...

hrp0082p1-d2-217 | Reproduction (1) | ESPE2014

Reference Charts for Testicular Volume in Dutch Children and Adolescents

Joustra Sjoerd , van der Plas Evelyn , Goede Joery , Oostdijk Wilma , Delemarre - Van de Waal Henriette , Hack Wilfried , van Buuren Stef , Maarten Wit Jan

Background: Measurement of testicular volume is important when conditions associated with a delay or advance in the onset of puberty, or micro- and macroorchidism, are suspected. Measured testicular volumes must be compared with reference data, preferably expressed in S.D. curves using the LMS method, as is routinely done for many auxological measurements in pediatrics. The current study therefore aimed to construct LMS-smoothed age-reference charts for testicul...

hrp0084p2-256 | Diabetes | ESPE2015

Exposure to Phthalates and Phenols in Relation to Gestational Blood Glucose Homeostasis

Fisher Benjamin G. , Frederiksen Hanne , Andersson Anna-Maria , Juul Anders , Thankamony Ajay , Ong Ken K. , Dunger David B. , Hughes Ieuan A. , Acerini Carlo L.

Background: Endocrine disrupting chemicals (EDCs), such as phthalates and bisphenol A (BPA), have been associated with insulin resistance (IR) and type 2 diabetes (T2D) in non-pregnant adults. By contrast, recent pilot studies of pregnant women found negative associations between phthalates and blood glucose, and a lack of association with BPA. No studies have examined gestational IR or secretion in relation to EDC exposure.Objective: To confirm these re...

hrp0097s3.3 | Endocrine effects of cancer treatment | ESPE2023

Fertility preservation in children with cancer

Mitchell Rod

Fertility is dependent on the normal development of germ cells, which is controlled by hormones and paracrine factors produced by the somatic cells within the gonads. However, exposure to cancer treatment during childhood can cause damage to the gonads leading to infertility in adulthood [1]. This presentation will explore how various cancer treatments affect gonadal function based on clinical evidence in patients [2], experimental models involving animals and studies utilisin...

hrp0086p1-p480 | Fat Metabolism and Obesity P1 | ESPE2016

Associations of Different Appetite Hormones with Physical Activity and Cardiorespiratory Fitness in Adolescent Boys with Different BMI Values

Tillmann Vallo , Remmel Liina , Purge Priit , Latt Evelin , Jurimae Jaak

Background: Higher physical activity (PA) attenuates the health risks of obesity and has positive effects on body weight reduction. The results of our recent longitudinal study showed that PA, especially vigorous PA (VPA), is an important factor for predicting overweight in boys during puberty (Lätt et al., 2015).Objective and hypotheses: The aim of this study was to examine the associations of fasting serum acylated and des-acylated ghreli...

hrp0094p1-16 | Bone A | ESPE2021

Leptin to adiponectin ratio at the age of 12 is negatively associated with lumbar spine bone mineral apparent density independently of body fat mass in 18-year old males.

Tamme Reeli , Jurimae Jaak , Maestu Evelin , Remmel Liina , Purge Priit , Mengel Eva , Tillmann Vallo ,

Background: Inconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported.Aim: To examine associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at 18 years of age and increase of bone mineral characteristics until 18 years of age.Materials and methods: 88 boys were investigated with a ...

hrp0095p1-218 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Pubertal Increment in Insulin Resistance is Negatively Associated with Lumbar Bone Mineral Density in 18-Year-Old Males Independently of Body Composition

Mengel Eva , Tamme Reeli , Remmel Liina , Purge Priit , Mäestu Evelin , Jürimäe Jaak , Tillmann Vallo

Aim: Insulin resistance is known to be closely related to the development of obesity and type 2 diabetes, whereas transient insulin resistance is part of the physiological developmental processes during pubertal years. However, insulin resistance might have detrimental effect on growing bone and bone mineral accrual. The aim of the present study was to identify whether increase in insulin resistance during pubertal years contribute to bone mineral characterist...

hrp0092p1-17 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Serum Testosterone Level at the Age of 12 is an Important Determinant of the Following Gain of Bone Mineral Apparant Density in 18-year Old Males: a Longitudinal Study From Puberty

Tamme Reeli , Jürimäe Jaak , Remmel Liina , Mäestu Evelin , Purge Priit , Mengel Eva , Tillmann Vallo

Background: Many cross-sectional studies have demonstrated that serum testosterone concentration is an important biochemical predictor of bone mineral density in young males, but to our knowledge, no longitudinal studies have been carried out to support these cross-sectional data.Aims: to examine the associations between serum testosterone concentration at the age of 12 and the following gain in bone mineral density unti...

hrp0082p1-d3-226 | Reproduction (2) | ESPE2014

Serum Leptin, Ghrelin, and Adiponectin Levels in Relation to Body Composition in Rhythmic Gymnasts Entering into Puberty: a 3-year Follow-up Study

Tillmann Vallo , Vosaberg Kristel , JurimParm Anna-Liisa , Saar Meeli , Jurimae Toivo , Maasalu Katre , Neissaar Inga , Latt Evelin , Jurimae Jaak

The aim: Of this study was to describe longitudinal changes in body composition and serum leptin, ghrelin and adiponectin levels over 36-month period in prepubertal rhythmic gymnasts (RG) and their age-matched untrained controls (UC) entering into puberty.Methods: 35 RG (mean age 8.0±0.6 years) and 33 UC (8.2±0.6 years) were followed at 12-month intervals for the next 3 years. Height, weight, pubertal stage, body composition by DXA and serum le...