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hrp0086rfc5.4 | Management of Disorders of Insulin Secretion | ESPE2016

“Transient” Neonatal Diabetes In Adulthood: Metabolic Outcomes

Busiah Kanetee , Baz Baz , Lebourgeois Fleur , Djoudi Malek Ait , Bachere Nadege , Bourron Olivier , Ythier Hubert , Pouvreau Nathalie , Bellanne-Chantelot Christine , Vialettes Bernard , Gourdy Pierre , Hartemann Agnes , Robert Jean-Jacques , Cave Helene , Polak Michel , Gautier Jean-Francois

Background: Transient Neonatal Diabetes Mellitus (TNDM) is a rare genetic beta cells dysfunction leading to hyperglycaemia that resolves in early childhood. About 80% of patients relapse during adolescence or adulthood. Glucose homeostasis had not been investigated in adulthood.Objective and hypotheses: To investigate insulin secretion and insulin sensitivity in adults affected with TNDM or in their 1st degree mutated relatives.</p...

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hrp0086p1-p209 | Diabetes P1 | ESPE2016

Association between Hypothalamus–Pituitary Adrenal Axis Activity and Anxiety in Prepubertal Children with Type 1 Diabetes

Barat Pascal , Brossaud Julie , Bereron Aude , Corcuff Jean-Benoit , Moisan Marie-Pierre , Lacoste Aurelie , Vautier Vanessa , Savel Helene , Perez Paul

Background: Animal models of insulin-dependent diabetes show hyperactivity of hypothalamuspituitary adrenal (HPA) axis, independently of hypoglycaemia. Few data exists regarding type 1 diabetes (T1D) in children.Objective: To describe HPA axis activity according to the anxiety levels in prepubertal T1D children.Method: Prepubertal T1D children and siblings of T1D children (controls) were included. State-Trait Anxiety Inventor...

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ESPE Abstracts

“Transient” Neonatal Diabetes In Adulthood: Metabolic Outcomes

Association between Hypothalamus–Pituitary Adrenal Axis Activity and Anxiety in Prepubertal Children with Type 1 Diabetes

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