hrp0089fc12.5 | Diabetes and Insulin 2 | ESPE2018

Effect of Homocysteine-Lowering Therapy on Diabetic Nephropathy in children and adolescents with Type 1 Diabetes

Elbarbary Nancy , Ismail Eman Abdel Rahman , Zaki Mamdouh Ahmed , Ibrahim Marwa Zaki , El-Hamamsy Manal

Background: Diabetic nephropathy (DN) is a major microvascular complica-tion of type 1 diabetes mellitus (T1DM). Homocysteine levels have been found elevated in T1DM patients with DN due to several causes, including dietary deficiencies of folic acid and B Vitamins. Hyperhomocysteinemia induces renal injury and is associated with increasing urinary albumin excretion in patients with diabetes. We therefore performed a randomized-controlled trial of oral supplem...

hrp0098p1-35 | Diabetes and Insulin 2 | ESPE2024

Diabetes Mellitus in Woodhouse -Sakati syndrome

Amin Rasha , Khalifa Amel , Petrovski Goran , Mohammed Elwaseila , Dauleh Hajar , Haris Basma , Chirayath Shiga , Mohamadsalih Ghassan , Al Bureshad Khalid , Ibrahim Marwa , Hussain Khalid

Background: Woodhouse-Sakati syndrome (WSS) is a rare, autosomal recessive genetic disorder with variable clinical manifestations mainly affecting the endocrine and nervous systems. Diabetes mellitus is one endocrine manifestation but there are no comprehensive data on the epidemiology, clinical features, underlying mechanisms, and management, particularly within the Qatari population.Methods: This retrospective study wa...

hrp0098fc6.1 | Fat, Metabolism and Obesity 1 | ESPE2024

Corneal Nerve Loss and regeneration after GLP-1 Therapy in Children with Simple and Monogenic Obesity

Gad Hoda , Dauleh Hajar , Chirayath Shiga , Amin Rasha , Mohamadsalih Ghassan , Pasha Maheen , Mohammed Idris , Al-Barazenji Tara , Khalifa Amel , Petrovski Goran , Hamdoun Elwaseila , Al Bureshad Khalid , Ibrahim Marwa , A. Malik Rayaz , Hussain Khalid

Background: Obesity is highly prevalent in the MENA region, especially in children and it has been associated with neurodegeneration. We have undertaken corneal confocal microscopy (CCM) to assess for evidence of neurodegeneration in children with simple obesity and monogenic obesity (MC4R gene mutation) and further assessed the effect of glucagon-like peptide 1 agonist (GLP-1) therapy on corneal nerve regeneration.Methods:</stro...

hrp0098p2-109 | Fat, Metabolism and Obesity | ESPE2024

Single-center experience in using a once weekly Semaglutide injection in adolescents with obesity +/- Type 2 diabetes

Dauleh Hajar , Amin Rasha , Pasha Maheen , Gad Hoda , Elshareif Tamara , Khalifa Amel , Petrovski Goran , Ahmed Elwaseila , Mohamadsalih Ghassan , Chirayath Shiga , Albureshad Khalid , Ibrahim Marwa , Campbell Judith , Hamdan Manar , Almajaly Douha , Umer Fareeda , Albahri Aya , Isamil Fatima , Saeed Sara , almasarweh Hadeel , cuatrona Erlinda , Biglangawa Roshirl , Inso Gina , Aler Joanna , A.Eyalawwad Ayah , Malik Rayaz , Hussain Khalid

Background: Childhood obesity presents a significant global health concern, leading to long-term morbidity and mortality. While lifestyle interventions remain fundamental, pharmacological approaches, particularly using glucagon-like peptide-1 (GLP-1) receptor agonists, show promise in certain patient populations. However, studies exploring this avenue, particularly in the Middle East and North African region, are limited. This study aims to share our experienc...

hrp0084p3-582 | Adrenals | ESPE2015

Rapid Molecular Diagnosis of CAH by Strip Hybridisation Assay in DEMPU

El-Mougy Fatma , Hafez Mona , Atty Sahar Abdel , Ibrahim Amany , Mehawed Hend , Musa Noha , Ekladious Sherif , Elsharkawy Marwa , Abdullatif Mona , Afif Alaa , Baz Heba El

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder in which more than 90% of CAH cases are caused by mutations of the 21-hydroxylase (CYP21A2) gene.Objective and hypotheses: To determine the mutational spectrum in Egyptian CAH patients attending Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU) including family members of CAH patients.Method: The use of reverse hybridization assay for the mol...

hrp0084p2-286 | Diabetes | ESPE2015

Assessment of Ventricular Function by Tissue Doppler Echocardiography in Children and Adolescents with Type 1 Diabetes Mellitus

Abdelghaffar Shereen , Salah Nermeen , Attia Mona , Hafez Mona , Mamdouh Mona , Atef Abeer , Elmougy Fatma , Abdelaty Sahar , Ibrahim Amany , Mehawed Hend , Musa Noha , Arafa Noha , Farouk Marwa , Ismail Mohamed , Abdelaziz Faten , Fattouh Aya , Hussein Eman , Ghali Isis

Background: Tissue Doppler echocardiography can predict early stages and progression of diabetic cardiac changes; especially ventricular dysfunction, a complication that adversely affect the quality of life and prognosis of the disease.Objective and hypotheses: The aim of this study was to assess systolic and diastolic functions of both ventricles in type 1 diabetes (T1D) patients by conventional and Tissue Doppler echocardiography, and to correlate card...

hrp0092p3-228 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Comparison of Classical and Non-Classical Turner Syndrome at NICH Karachi

Ibrahim Mohsina

Objective: To analyse chromosomal abnormalities of the patients who were referred for the screening of short stature and delayed puberty and to verify the association between karyotype and phenotype in confirmed Turner Syndrome (TS) patients.Study Design: Descriptive study. Place and Duration of Study: Department of Pediatric Endocrinology and Diabetes Unit-II, National Institute of Child Health, Karachi, from January 20...

hrp0084fc5.6 | Endocrine Oncology/Turner | ESPE2015

Anti-Müllerian Hormone Levels in Patients with Turner Syndrome: Relation to Karyotype, Pubertal Development and GH Therapy

Hamza Rasha , Mira Marwa , Hamed Amira

Background: Gonadal dysgenesis in Turner syndrome (TS) results in pubertal delay or failure and infertility in most patients. However, up to 30% of girls with TS have spontaneous pubertal development and 2–5% have regular menstrual cycles before the onset of premature menopause. Serum anti-Mullerian (AMH) levels reflect the ovarian reserve in females, even in childhood.Objective and hypotheses: To Asses serum AMH levels in patients with TS and its r...

hrp0084p3-1089 | Perinatal | ESPE2015

Cord Blood and Maternal Serum IGF1,2, IGFBP3 Levels in Overweight Pregnants

Akinci Aysehan , Celik Onder , Ozerol Ibrahim

Background: Obesity or excess weight gain in pregnancy period cause increased insulin secretion even if glucose screening test is normal. The growth promoting effect of insulin may release somatotropic hormones, such as IGF1,2 and its binding proteins are involved in the regulation of foetal growth.Objective and hypotheses: In this study, we determined the changes of intrauterine growth factors (IGF1,2, and IGFBP3) in pregnants gained over weight during ...

hrp0094p2-337 | Multisystem endocrine disorders | ESPE2021

Van Wyk Grumbach Syndrome in an Egyptian Female Pediatric Patient: a rare presentation of a common disease

Ibrahim Amany , Abdel Rahman Alshaimaa Mahfouz ,

Background: Van Wyc-Grumbach syndrome is a rare presentation of long standing pre-pubertal hypothyroidism characterized by bilateral multicystic ovaries, vaginal bleeding and delayed skeletal growth in case of female.Case Presentation: we present a clinical course, diagnosis and management of a case of Van Wyc-Grumbach syndrome in a 10-years old Egyptian counselled for recurrent vaginal bleeding and pubertal advancement for age. She was ...