ESPE Abstracts

Background and aim: Hypothyroidism could be accountable for cardiovascular diseases; hence, necessity of novel biomarkers being capable to predict patient’s status is indispensable. The aim of this study was to appraise alteration of plasma visfatin levels (as a newly discovered proteins) and its association with lipid profiles of hypothyroid patients.Materials and methods: In this cross-sectional, descriptive, and analytical study, 30 children bein...

Background: Type 1 diabetes mellitus (T1DM) has been described to be associated with altered oxidative status. Combined analysis of pro-oxidative and anti-oxidative mechanisms in youngsters with T1DM has been less studied.Objective and hypotheses: To evaluate pro-oxidative/anti-oxidative status in T1DM youngsters and healthy controls and investigate their possible association with glycemic control.Method: Sixty-three children and a...

Introduction: Our Centre is an international referral centre for genetic analysis of children with short stature (SS) and features of GH/IGF-1 resistance. Following candidate gene and whole exome sequencing, diagnoses for ~50% patients remained elusive. Copy number variation (CNV) has not previously been investigated in GH/IGF-1 resistance and we hypothesised that CNVs contribute to the phenotype in our undiagnosed cohort.Experimental Design and Methodol...