Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

hrp0082p2-d1-318 | Diabetes | ESPE2014

Serum Level of Osteoprotegerin and Total sRANKL in Adolescents with Type 1 Diabetes Mellitus

Szalecki Mieczyslaw , Wierzbicka Elzbieta , Pludowski Pawel , Jaworski Maciej

Background: There is still small clinical data regarding the influence of IDDM on bone structure, density and biochemical markers of bone turnover.Objective and hypotheses: To evaluate the potential role of OPG/sRANKL system in adolescents with IDDM and the influence of age, sex, metabolic control, diabetes duration and age of onset.Method: Serum concentration of OPG and total sRANKL in 60 children (25 boys and 33 girls) with IDDM ...

hrp0082p2-d1-319 | Diabetes | ESPE2014

Simultaneous Changes in Trends in Incidence of Children Diabetes Type 1 in Distant Geographic Regions

Fuentes-Bolanos Noemi Auxiliadora , Arroyo Diez Francisco Javier , Carballar Violeta Delgado , Perez Pilar Mendez , Estevez Manuela Nunez

Introduction: The epidemiology of childhood type 1 diabetes (DM1) allows to understand the genetics and enviromental factors involve in one of the most prevalent chronic disease in children. The unification of methodological recommendations has allowed to detect new research lines.Method: We present an observational study of population under 13 years old and DM1 in Extremadura (1996–2011). The aim was to examine secular trends in the incidence of DM...

hrp0082p2-d1-320 | Diabetes | ESPE2014

Risk Factors for Type 2 Diabetes Mellitus in Secondary School Students in Port Harcourt Nigeria

Jaja Tamunopriye , Yarhere Iroro

Background: There is evidence to suggest an increase in type 2 diabetes mellitus worldwide even in children and adolescents. It is usually preceded by a period known as prediabetes and other risk factors such as elevated blood pressure, obesity, hypertriglyceridemia and family history of diabetes mellitus.Objective and hypotheses: To determine the number of risk factors for type 2 DM in each subject studied for selected risk factors.<p class="abstext...

hrp0082p2-d1-321 | Diabetes | ESPE2014

Interaction of Pubertal Development and Metabolic Control in 1303 Adolescents with Diabetes Mellitus Type 1

Hamm Michaela , Gohlke Bettina , Wolfle Joachim , Fink Katharina , Konrad Katja , Rohrer Tilman , Hofer Sabine , Holl Reinhard

Background: T1DM may influence growth and pubertal development and vice versa. Delayed pubertal development and reduced final height are known to be associated with inadequate metabolic control. Many factors including insulin resistance during puberty and insufficient adherence may be responsible for increasing HbA1c.Objective: Is pubertal growth spurt associated with an increase of HbA1c? Are there gender differences in metabolic control during...

hrp0082p2-d1-322 | Diabetes | ESPE2014

Quality of Life and Glycaemic Assessment Before and After Pump School

Leahy Patricia , O'Toole Norma , O'Connell Susan , O'Riordan Stephen

Background: Childhood type 1 diabetes (T1DM) is associated with poor quality of life and significant family burden. Children, parents, extended family members and teachers were invited to a novel 2 day structured educational programme, ‘Pump SchooI’, delivered by a Consultant Led multidisciplinary team. Each Pump School included two age-matched children.Objective and hypotheses: To evaluate the effect of continuous s.c. insulin infusion (CSII) ...

hrp0082p2-d1-323 | Diabetes | ESPE2014

Improving Paediatric Diabetes Care with the Use of an Electronic Diabetes Information Management System (Twinkle.Net) and Routine Uploading of Blood Glucose Meters and Insulin Pumps (Diasend) in Outpatient Clinic

Ng Sze May , Connellan Linda , Finnigan Lynne

Background: The UK has the highest number of children and young people with type 1 diabetes mellitus in Europe, but the lowest number of children and young people attaining good diabetes control.Methods: In December 2012, our diabetes service established the use of an electronic diabetes information management system that was web-based (Twinkle.Net) and routine uploading of glucose meters and pumps (Diasend). The electronic management system Twinkle.Net ...

hrp0082p2-d1-324 | Diabetes | ESPE2014

Two Novel Homozygous Mutations in WFS1 Gene in Two Turkish Families with Mild Phenotypic Expression of Wolfram Syndrome

Sherif Maha , Demirbilek Huseyin , Cayir Atilla , Ozbek Mehmet Nuri , Baran Riza Taner , Cebeci Ayse Nurcan , Tahir Sophia , Rahman Sofia , Dattani Mehul , Hussain Khalid

Background: Wolfram syndrome (WS or DIDMOAD) is a rare (prevalence of 1/770,000) autosomal recessive multi-systemic neurodegenerative disease, characterized by non-autoimmune diabetes mellitus (DM) and optic atrophy. Additional features include diabetes insipidus (DI), sensorineural deafness, urinary tract abnormalities, ataxia, psychiatric illness, and other endocrine disturbances leading to death in mid-adulthood. This syndrome is caused by recessive mutations in the wolfram...

hrp0082p2-d1-325 | Diabetes | ESPE2014

Imbalance Between Pro-Oxidative and Anti-Oxidative Mechanisms in Children and Adolescents with Type 1 Diabetes Mellitus

Karampali Maria , Kyrgios Ioannis , Kalogiannis Stavros , Efstratiou Efthimia , Galli-Tsinopoulou Assimina

Background: Type 1 diabetes mellitus (T1DM) has been described to be associated with altered oxidative status. Combined analysis of pro-oxidative and anti-oxidative mechanisms in youngsters with T1DM has been less studied.Objective and hypotheses: To evaluate pro-oxidative/anti-oxidative status in T1DM youngsters and healthy controls and investigate their possible association with glycemic control.Method: Sixty-three children and a...

hrp0082p2-d1-326 | Diabetes | ESPE2014

Trends in Incidence and Prevalence of DM Type 1 in Children in Ukraine During 2002–2012

Globa Evgenia , Zelinska Nataliya

Background: The aim of the study was to describe the incidence and prevalence trends of diabetes mellitus (DM) type 1 in children of different age groups in Ukraine during 2002–2012.Objective and hypotheses: Ukraine has a 25 districts, with a population of 45 553 000, including 7 971 638 children.Method: We analyzed data based on a clinical diagnosis in child population aged 0–17 years old centrally from all regions of Uk...

hrp0082p2-d1-327 | Diabetes | ESPE2014

Effectiveness of Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes

Osokina Darya , Osokina Irina

Background: Consistent use of insulin pump therapy and continuous glucose monitoring (CGM) has been shown to improve glycemic control and reduce hypoglycemia.Objective and hypotheses: The aim this study compared multiple daily injection (MDI) therapy to pump insulin therapy (CSII) in children and adolescents.Method: A total of 28 children (aged 7–12) and 34 adolescents (aged 13–18) participated in this study. The particip...

hrp0082p2-d1-328 | Diabetes | ESPE2014

Functional Condition of the Kidneys (K/DOQI, 2002) By ACE Gene I/D Polymorphism in Children and Adolescents with Type I Diabetes Mellitus

Sadykova Akidahon , Rakhimova Gulnara

Objective and hypotheses: The work was initiated to assess functional condition of the kidneys and to study interrelation between ACE gene I/D polymorphism and stage of chronic kidney disease in children and adolescents with type 1 diabetes mellitus (DM) in compliance with K/DOQI recommendations (2002).Method: We examined 120 children and adolescents with type 1 DM, 53 (44.2%) males and 67 (55.8%) females among them (mean age 13.8±0.24 years. GFR wa...