Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Diabetes (1)

hrp0082p2-d2-329 | Diabetes (1) | ESPE2014

Lipid Profile is Related to Androgen Level in Adolescent Girls with Type 1 Diabetes Mellitus

Zachurzok Agnieszka , Deja Grazyna , Gawlik Aneta , Drosdzol-Cop Agnieszka , Malecka-Tendera Ewa

Background: The mechanisms underlying dyslipidaemia in the context of polycystic ovary syndrome may include not only metabolic aberrations but also hormonal factors, in particular hyperandrogenaemia.Objective and hypotheses: The aim of the study was to establish whether dyslipidaemia and metabolic control disturbances are related to hyperandrogenaemia in adolescent girls with type 1 diabetes mellitus (T1DM).Method: We studied 54 gi...

hrp0082p2-d2-330 | Diabetes (1) | ESPE2014

A Multicentre Study Evaluating the Risk and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Ng Sze May , Ayoola Omolola O , McGuigan Michael , Chandrasekaran Surendran

Background: There is currently limited data published on the prevalence of diabetic eye disease in children and young people (CYP) with type 1 diabetes mellitus (T1DM), yet diabetic retinopathy remains one of the commonest causes of blindness in young adults.Objectives: To determine the risk and prevalence of diabetic retinopathy and to evaluate the risk factors associated with diabetic retinopathy in CYP with T1DM.Methods: All CYP...

hrp0082p2-d2-331 | Diabetes (1) | ESPE2014

ACE Gene Insertion/Deletion Polymorphism and ACE Enzymatic Activity in Egyptian Children with Type 1 Diabetes with and without Microalbuminuria

Anwar Ghada , Bazaraa Hafez , Shaker Olfat , Arafa Noha , Hafez Mona , Mousa Noha

Background: Diabetic nephropathy is a major cause of morbidity and mortality among young adults with type 1 diabetes mellitus. Strong evidence exists in multiple studies for genetic predisposition of diabetic nephropathy. Genetic studies have revealed that the genes for the renin–angiotensin system (RAS) are highly polymorphic, one of such is insertion/deletion polymorphism in ACE gene. This polymorphism was associated with the circulating ACE level and increased plasma a...

hrp0082p2-d2-332 | Diabetes (1) | ESPE2014

Game Interaction Between a Humanoid Robot and a Diabetic Teenager: Might This Improve Motivation to Fill in the Nutritional Diary?

Sanna Alberto , Baroni Ilaria , Oleari Elettra , Colombini Maria Iole , Pozzi Clara , Russo Gianni , Rigamonti Andrea , Frontino Giulio , Favalli Valeria , Battaglino Roseila , Bonura Clara , Bonfanti Riccardo , Ferro Giusy , Chiumello Giuseppe

Introduction: This study describes the experience of introducing Nao, a humanoid robot, into a Summer Camp for children with diabetes (August 2013, Misano Adriatico, Italy), with the aim to provide them a companion capable to support and motivate. Our goal was to investigate if, Nao’s interactions with children could positively affect the adherence to specific medical recommendations during their stay. Namely children were asked to fill in a specific nutritional diary. Th...

hrp0082p2-d2-333 | Diabetes (1) | ESPE2014

A Novel AVPR2 Mutation (L161P) Causing Partial Nephrogenic Diabetes Insipidus

Yamashita Sumie , Hata Astuko , Kaneko Naoto , Usui Takeshi , Hata Daisuke

Background: Nephrogenic diabetes insipidus (NDI) is a disorder characterized by renal resistance to the antidiuretic effect of AVP. Affected patients are exhibiting symptoms as polyuria and polydipsia. Approximately 90% of congenital NDI are inherited in an X-linked recessive manner and caused by mutations of arginine vasopressin type 2 receptor (AVPR2) gene.Objective and hypotheses: An 8-year-old Japanese boy was referred to our hospital for nocturnal e...

hrp0082p2-d2-334 | Diabetes (1) | ESPE2014

New-Onset Type 2 Diabetes Presenting with Hyperglycaemic Hyperosmolar State in a Renal Transplant Patient on GH Treatment

Harrington Francesca , Makaya Taffy , Wolfenden Helen

Background: Hyperglycaemic hyperosmolar state (HHS) is a life-threatening condition rarely seen in paediatrics. It is however becoming increasingly recognised with the growing incidence of childhood type 2 diabetes mellitus (T2DM).Objective and hypotheses: We present a child with Bardet–Biedel syndrome (BBS), with new-onset T2DM presenting in HHS, and discuss the dilemmas encountered in his management due to multiple co-morbidities, including renal ...

hrp0082p2-d2-335 | Diabetes (1) | ESPE2014

Insulin Therapy via Tubeless Patch Pump: Really an Alternative?

Boettcher Claudia , Schaefer Maike , Weiss Lucia , Wudy Stefan A

Background: For a few years now tubeless disposable patch pumps are available for insulin therapy.Objective and hypotheses: Alarmed by initially non explainable beginning metabolic decompensation of two children with type 1 diabetes during their hospital stay for the initial therapy adjustment with patch pumps and alarmed by patients’ reports of frequent premature pump changes and alarms, we decided to scrutinize the patch pumps under laboratory con...

hrp0082p2-d2-336 | Diabetes (1) | ESPE2014

GAD Antibody Positivity is Associated with Higher Prevalence of Autoimmune Thyroiditis in Children with Type 1 Diabetes Mellitus

Abali Saygin , Celik Enes , Haliloglu Belma , Bas Serpil , Atay Zeynep , Turan Serap , Bereket Abdullah

Background: The prevalence of autoimmune thyroid disease is higher in children with type 1 diabetes mellitus (T1DM).Objective and hypotheses: The aim of this study is to compare the frequency of autoimmune thyroiditis in children with T1DM according to the presence of diabetes autoantibodies.Method: This study included 533 (49% female) children with T1DM based on hospital records from a single center. Frequency of glutamic acid dec...

hrp0082p2-d2-337 | Diabetes (1) | ESPE2014

The Length of the Deletion in the Region 17q Contributes to the Individual Variability of the Phenotype of Patients with Renal Cysts and Diabetes Syndrome (RCAD, HNF1B-MODY)

Pruhova Stepanka , Dusatkova Petra , Malina Michal , Slamova Zuzana , Blahova Kveta , Kotalova Radana , Dusek Jiri , Lebl Jan , Seeman Tomas , Cinek Ondrej

Background: The renal cysts and diabetes (RCAD) syndrome caused by defects in the HNF1B is characterized by a broad spectrum of clinical features. While heterozygous point mutations are relatively rare, we focused on gross deletions of the HNF1B that are determined by multiplex ligation probe-dependent amplification (MLPA). Rather importantly, the deletions most often extend beyond the single HNF1B, thus more deleted genes may participate in the clin...

hrp0082p2-d2-338 | Diabetes (1) | ESPE2014

Urinary Vitamin E Metabolites as a Biomarker of Oxidative Stress in Type 1 Diabetes

Bulwer Chloe , Hindmarsh Peter , Pope Simon , Tollerfield Sally , Sirka Ernestas , Mills Kevin

Background: Oxidative stress has been implicated in the development and progression of complications in type 1 diabetes (T1DM). Vitamin E (α-tocopherol) undergoes β-oxidation of its chomanol ring and the resulting metabolite α-TLHQ has been proposed as a potential biomarker of oxidative stress. HbA1c relates in T1DM to microvascular complications predominantly although the end-points are late in disease development. The oxidative stress process may act independe...

hrp0082p2-d2-339 | Diabetes (1) | ESPE2014

Direct Costs of Diabetes Care in Pediatric Patients with Type 1 Diabetes in Greece

Karachaliou Feneli , Athanasakis Konstantinos , Tsendidis Charalabos , Kitra Maria , Michalakos Stefanos , Karavanaki Kyriaki

Background: Type 1 diabetes (T1DM) is a chronic disease with increasing incidence and major impact on the health care costs.Objective and hypotheses: To estimate the direct cost of pediatric T1DM in the Greek National Health System (NHS) and its distribution by service category.Method: This is a retrospective cost-of-illness study, focusing on the direct costs from the healthcare system’s point of view. All patients aged 0&#15...