hrp0098p3-180 | Multisystem Endocrine Disorders | ESPE2024

Sleep disturbances among 4 to 12 year-old Filipino children with drug resistant epilepsy in a Pediatric Tertiary Hospital in the Philippines

Andrea Llaneta Cherise , Michel Villaluz Mel

Objective: To perform a pilot study on the frequency of sleep-disturbance (Total sleep Disturbance Score (TSD) of > 41) in children diagnosed with Drug Resistant Epilepsy aged 4 to 12 years, using the Children’s Sleep Habits Questionnaire (CSHQ).Method: The Children’s Sleep Habits Questionnaire (CSHQ) was used to screen for sleep disturbances among 73 patients aged 4 to 12 years old, with drug-resistant ep...

hrp0086s2.2 | Genetics and epigenetics of thyroid dysgenesis | ESPE2016

Genetics of Thyroid Dysgenesis and Associated Malformations

Polak Michel

Thyroid dysgenesis (TD) is the most common cause of congenital hypothyroidism in iodine sufficient regions. TD includes a broad spectrum of developmental anomalies varying from absence of thyroid (athyreosis) to an abnormally located thyroid (ectopy), small (hypoplasia) or asymmetric thyroid. Thyroid dysgenesis is usually sporadic, but up to 2% of cases is familial. Genetics of TD is complex and advances in developmental biology over the past two decades revealed monogenetic f...

hrp0084wg2.2 | Diabetes Technology and Therapeutics Thursday, 1 October | ESPE2015

The Pros and Cons of Using Sulfonylurea before Genetic Testing in Neonatal Diabetes Mellitus

Polak Michel

Background: Very early onset diabetes mellitus (neonatal diabetes mellitus (NDM)) seems to be unrelated to autoimmunity in most instances. A number of conditions are associated with NDM, some of which have been elucidated at the molecular level. Among these, the recently elucidated mutations in the KCNJ11 and ABCC8 genes, encoding the Kir6.2 and SUR1 subunit of the pancreatic KATP channel involved in regulation of insulin secretion, account for one...

hrp0094ern1.1 | Endo-ERN Symposium | ESPE2021

Update on the consensus on Congenital Hypothyroidism: a patient-centered approach

Polak Michel ,

Background: An ENDO-ERN initiative was launched which was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). A systematic literature search was conducted to identify key articles on neonatal screening, diagnosis and management of prima...

hrp0095p1-42 | Diabetes and Insulin | ESPE2022

Symptoms and Glycemic Control in Young People with Type 1 Diabetes following SARS-CoV-2 Infection: an Observational Study

Nimri Revital , Rachmiel Marianna , Yackobovitch-Gavan Michal , Brener Avivit , de Vries Liat , Fisch Shvalb Naama , Lazar Liora , Oren Asaf , Jacobi-Polishook Talia , Shefer Averbuch Noa , Tenenbaum Ariel , Mel Eran , Krepel Volsky Sari , Mouler Marie , Demol Sharon , Shalitin Shlomit , Bello Rachel , Phillip Moshe , Lebenthal Yael

Objective: To describe clinical manifestations of SARS-CoV-2 infection in children, adolescents, and young adults with established type 1 diabetes and explore the effects of COVID-19 on glycemic control and disease course.Methods: Observational study conducted at three pediatric diabetes clinics in Israel between mid-March-2020 and mid-March-2021. Included were young people with established type 1 diabetes, <30years, ...

hrp0084p3-657 | Bone | ESPE2015

Discrepancy in Bone Age Rating Using Tanner-Whitehouse Rating and Automated Bone Age Determination in a Child Who was Later Diagnosed with Metaphyseal Dysplasia

Birkebaek Niels , Hellfritzsch Michel

Background: In the last 50 years bone age has been manually evaluated using the method of Tanner and Whitehouse. Recently automated image analysis has been introduced for bone age determination. The automated method shows good agreement with manual evaluation; further, the precision of the automated method may be higher compared to the manual method.Objective and hypotheses: To report on the discrepancy of bone age determination using the manual TW2 meth...

hrp0084p3-933 | GH &amp; IGF | ESPE2015

Adult Height in Children Born Small for Gestational Age and Treated with GH: Data from the French KIGS Database

Polak Michel , Czernichow Paul

Background: Treatment with GH in children born small for gestational age (SGA) increases height velocity (HV) but data on adult height (AH) are scarce.Objective and hypotheses: To report AH in a group of SGA children treated with GH.Method: This is a post-marketing longitudinal analysis of SGA children treated with GH and included in France in KIGS. Selection criteria were children followed at least one year and having reached AH b...

hrp0084p1-44 | Diabetes | ESPE2015

Is Metabolic Control Affected by Military Service in Young Adults with Type 1 Diabetes?

Brener Avivit , Mel Eran , Shalitin Shlomit , Lazar Liora , de Vries Liat , Tenebaum Ariel , Oron Tal , Philip Moshe , Lebenthal Yael

Background: Young adults with type 1 diabetes (T1D) are exempt from conscript military service due to risk of severe hypoglycaemia and metabolic compromise. Nevertheless, there are patients who volunteer to military service.Aims and objectives: To evaluate the effect of military service on metabolic control and incidence of acute diabetes complications.Methods: Study design: retrospective, comparative analysis. Data of 145 T1D pati...

hrp0095p1-504 | GH and IGFs | ESPE2022

easypod® Augmented Reality: Usability and acceptability of a virtual reality mobile solution to support training of patients on a connected injection device

Mericq Veronica , Kariyawasam Dulanjalee , Iñiguez German , PolakVeronica Mericq Michel , Kariyawasam Dulanjalee , Iñiguez German , PolakVeronica Mericq Michel , Kariyawasam Dulanjalee , Iñiguez German , PolakVeronica Mericq Michel , Kariyawasam Dulanjalee , Iñiguez German , Polak Michel

Background: Smartphones are becoming increasingly popular and powerful across the globe, which, in turn, has provided unforeseen opportunities in the digital health space. The increased capabilities of smartphones have allowed the incorporation of Augmented Reality (AR) capabilities that merge input from their cameras with additional, augmented annotations and representations. While there has been research on the use of AR in managing paediatric diabetes,1 to ...

hrp0095p1-107 | Growth and Syndromes | ESPE2022

Identifying several patient-related factors that predicted permanent growth hormone deficiency (GHD)

Mericq Veronica , Kariyawasam Dulanjalee , Iñiguez German , Polak Michel

GHD is the most common endocrine disorder in children with short stature (~1 in 4000). Appropriate diagnosis should synthesize auxological, biochemical and neuroradiological data. However, until now there are significant controversies, especially from the laboratory interpretation. A false positive diagnosis can lead to a significant wasted expenditure and unnecessary exposure to rare potential adverse effects. Given these open issues about biochemical diagnosis of GHD in chil...