ESPE Abstracts

The conspicuous increase in the incidence of type 1 diabetes (T1D) in the Western world after World War II cannot be explained solely by genetic factors but suggests that this rise must be due to crucial interactions between predisposing genes and environmental changes. Three parallel phenomena in early childhood – the dynamic development of the immune system, the maturation of the gut microbiome and the appearance of the first T1D-associated autoantibodies – imply...

The mammalian thyroid gland stands out in comparison to other organs as it develops from no less than three independent anlagen that originate in anterior endoderm. The median or central anlage present in the pharyngeal floor gives rise to the thyroid bud or diverticulum that provides progenitors to the thyroxin-producing follicular cells. Bilaterally, the ultimobranchial bodies bud off from the inferior-most pharyngeal pouch. Until recently those structures were considered me...

Background: An increased urinary albumin excretion rate of 30 to 300 mg/24h (microalbuminuria) constitutes an early stage of nephropathy, especially when it becomes persistent. The main modifiable initiation and progression factors of diabetic nephropathy are hyperglycemia and hypertension. There is limited information on the burden of diabetic nephropathy in developing countries. To date there are no studies that show the magnitude of microalbuminuria in the ...

Introduction: The human fecal microbiota is known to shift in composition during adolescence, but whether fecal microbiota is associated with timing of sexual maturation is unknown. In mice, the change in the composition of fecal microbiota during puberty appears to be sex-specific and associate with changes in testosterone. We investigated the association between intestinal microbiota and pubertal timing in adolescents.Subjects ...

Objective: Lifetime risk of having Type 1 Diabetes Mellitus [T1DM] increases when having a blood relative with T1DM. A Finish study reports 12.2% and 11.9% of T1DMs having a first degree relative [FDR] and second degree relative [SDR] with T1DM[1]. Data from India regarding proportion of children with T1DM FDR/SDR is non-existent. Objective is to find out the same.Methods: We examined the electronic database of 902 T1DM ...

Background: Borderline precocious and normal-onset puberty can show slow or fast course. The fast development of pubertal signs can be resulted in decrease in final height (FH) via accelerated growth and bone maturation.Objective and hypotheses: To study the effectiveness of GnRHa in improving FH in girls with advanced bone age (BA) and decreased predicted height (PH) in borderline early or normal physiological puberty.Method: 135 ...

Introduction/Aim: Children with Prader-Willi syndrome (PWS) show alterations in infantile, childhood and pubertal growth. Growth Hormone (GH) therapy is recommended due to reported improvements in height velocity (HV) and body composition. The aim was to describe the patterns of growth in PWS and the influence of both changes in clinical practice and GH therapy.Methods: Height SDS (HSDS), BMISDS and HVSDS of children attending a dedicated PWS clinic, 200...

Background: Pubertal gynaecomastia (PG) is considered a clinical sign of an oestrogen–androgen imbalance at the breast tissue level although little evidence exists. PG occurs in 40–60% of adolescent Caucasian boys, and in most cases however, no underlying endocrinopathy can be identified. Very few longitudinal studies on PG exist.Objective and method: As a part of the longitudinal COPENHAGEN Puberty Study we followed 110 healthy Danish boys (ag...

Background: Since the late 1960’s, pubertal breast staging has been based on Tanner’s classification. Appearance of glandular breast tissue may be difficult to distinguish by palpation from the surrounding subcutaneous fat tissue, especially in obese girls. To our knowledge, validation of the clinical assessment of pubertal stages by MRI quantification of glandular breast tissue has never been performed.Objective and hypotheses: i) To report no...

Background: Intermittent breast budding (girls entering stage B2 and then subsequently regressing to B1) in healthy girls is a frequent phenomenon observed by most clinicians. However, little is known of normal progression of female puberty, and the phenomenon of transient breast development has, to our knowledge, never been studied in details.Objective and hypotheses: We present and validate the female Puberty Nomogram indicating age specific SD<...