ESPE Abstracts

Obesity remains a critical global health concern. Traditional treatment often yields limited results, necessitating innovative solutions. The Evira tool; comprising a digitless scale and a mobile application with real-time feedback, addresses these challenges by enhancing home- based monitoring. The primary aimwas to evaluate its efficacy for childhood obesity treatment in Abu Dhabi, with a secondary objective to establish non-inferiority compared to outcomes in Stockholm, Swe...

Background: The integration of mobile health technology with a limited number of physical visits shows promising treatment outcomes, but long-term evidence is lacking. Additionally, concerns about eating disorders following obesity treatment are common among families and caregivers, although data on this matter are scarce for children and adolescents. This study evaluates three-year weight outcomes for patients using a digi-physical treatment tool and reviews ...

It is generally accepted that androgens produced by fetal Leydig cells (FLC) control proper masculinization of the male external genitalia. Here, we hypothesized that the human genital tubercle (GT) has potential to synthesize androgens independently of FLC at early pregnancy. We observed that human GT of both genders have capacity to synthesize steroids of the Δ4, Δ5 and alternative pathway of DHT synthesis including the androgen itself. The presence of steroids in ...

Background: Steroid hormones produced by the human fetal adrenals (HFA) are suggested to regulate intrauterine homeostasis and the maturation of certain fetal organs necessary for extrauterine life. Appropriate development and hormonal function of the HFA therefore are critical for normal fetal maturation and survival. Little is known about the possible relationship between the expression of steroidogenic enzymes and corresponding transcription factors in the HFA in vivo</...

Background: Managing diabetes requires self-care, knowledge and support – especially when moving from pediatric to adult care. Finding ways to empower young people in transition and transfer is therefore important.Objective: To develop, test and evaluate a mHealth app for young people with diabetes type 1 transferring from pediatric to adult care.Method: Development: We developed an app-prototype based on rapid prototyping and...

Background: Linear growth during spontaneous puberty contributes approximately 20% to adult height in healthy subjects. The impact of gender-affirming hormone therapy (GAHT) on final height in transgender adolescents is sparsely studied.Aim: We aimed to investigate the growth and final height of Danish transgender adolescents.Methods: Our national cohort of transgender adolescents ...

Background and Objectives: Early life might be a critical window for adiposity programming later in life. Metabolic profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic profile at 3 months of age is predictive for body composition at age 2 years and if there are differences between boys and girls and between infant feeding types.Methods: In 318 healthy t...

Background: Transgender adolescents may be treated with gender affirming hormone therapy (GAHT) consisting of gonadotropin-releasing hormone agonists (GnRHa) and cross-sex hormones. Limited data are available regarding the metabolic effects of GAHT in adolescence.Objective: To evaluate the lipid profiles and HbA1c in transgender adolescents after one year of cross-hormone treatment.Patients...

Background & Aim: The national Danish assessment and hormone treatment program for transgender adolescents started in 2016 and follows international guidelines. We aim to investigate the effects of hormone therapy on the sex steroid metabolite profile and gonadotropins.Methods: This observational study includes 219 transgender adolescents who started hormone therapy before 18 years of age comprising 55 individuals as...

Introduction: The pubertal transition is accompanied by voice break in boys. Studies asking men to retrospectively recall their age at voice break report an average age of voice break corresponding to 13.4-14.0 years. However, it may be difficult to remember precisely when your voice broke, and recall bias is quite large. Little is known about voice frequency in boys and girls in relation to pubertal timing.Aim: To asses...