Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

Online,
22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

ePoster Category 1

Fat, Metabolism and Obesity A

hrp0094p1-31 | Fat, Metabolism and Obesity A | ESPE2021

Efficacy and Safety of Setmelanotide in Individuals With Obesity Due to POMC or LEPR Deficiency: Phase 3 Results From Pivotal and Supplemental Cohorts

Farooqi Sadaf , Miller Jennifer , Ohayon Olga , Yuan Guojun , Scimia Cecilia , Stewart Murray , Yanovski Jack ,

Background: Disruption of the melanocortin-4 receptor pathway by genetic variants in POMC/PCSK1 or LEPR can result in hyperphagia and severe early-onset obesity. In the primary analyses of 2 pivotal Phase 3 trials, the melanocortin-4 receptor agonist setmelanotide was associated with significant reductions in body weight and hunger in patients with obesity due to proopiomelanocortin (POMC) or leptin receptor (LEPR) deficiency. These ...

hrp0094p1-32 | Fat, Metabolism and Obesity A | ESPE2021

Sex hormones drive changes in lipoprotein profiles in adolescents; early implications for cardiovascular disease risk

Robinson George , Peng Junjie , Peckham Hannah , Radziszewska Anna , Butler Gary , Pineda-Torra Ines , Jury Elizabeth , Ciurtin Coziana ,

Prior to menopause, it is known that women have a lower risk of cardiovascular disease (CVD) and coronary heart disease compared to age-matched men; it is reported that women have around half the CVD risk and almost a 10-year delay in first myocardial infarction event compared to men. Sex differences in serum lipids could contribute to CVD risk through driving atherosclerosis, the buildup of lipids in the sub-endothelial intimal layer of medium-sized to large arteries. We hypo...

hrp0094p1-33 | Fat, Metabolism and Obesity A | ESPE2021

Metabolomics in early life and the association with body composition at age 2 years

van Beijsterveldt Inge , Snowden Stuart , Myers Pernille Neve , Fluiter Kirsten de , Brix Susanne , Ong Ken , Dunger David , Hokken-Koelega Anita , Koulman Albert ,

Background and Objectives: Early life might be a critical window for adiposity programming later in life. Metabolic profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic profile at 3 months of age is predictive for body composition at age 2 years and if there are differences between boys and girls and between infant feeding types.Methods: In 318 healthy t...

hrp0094p1-34 | Fat, Metabolism and Obesity A | ESPE2021

High prevalence of undiagnosed metabolic dysfunction among children and adolescents with obesity in China

Wang Jinling , Fu Junfen ,

Objective: The aim here was to describe the characteristics of obese children and adolescents and to determine how the prevalence of comorbidities differed over 10 years in China.Methods: Obese children and adolescents were enrolled from Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine in Hangzhou (Zhejiang Province, China). Eligibility was defined by a body mass index ...

hrp0094p1-35 | Fat, Metabolism and Obesity A | ESPE2021

The possible association of the apoptotic marker APO1/Fas with predisposition to metabolic syndrome and mean platelet volume in children

Kostopoulou Eirini , Katsa Maria Efthymia , Magana Maria , Ioannidis Anastasios , Chatzipanagiotou Stylianos , Sachlas Athanasios , Spiliotis Bessie , Rojas Gil Andrea Paola ,

Objective: To investigate the possible relationship between APO1/Fas, components of metabolic syndrome and Mean Platelet Volume (MPV) in a healthy pediatric population.Study design: 185 children, aged 5-17 years old, were enrolled to the study. The participants were divided intο subgroups according to age and body mass index percentile (BMI%). APO1/Fas was measured by ELISA and MPV by the MEK-6410K.Re...

hrp0094p1-36 | Fat, Metabolism and Obesity A | ESPE2021

Reversal of metabolic derangement in patient with congenital generalized lipodystrophy treated with metreleptin

Aljubeh Jamal ,

Lipodystrophy syndromes are a heterogeneous cluster of complex, life-threatening, rare diseases associated with reduced levels of leptin and include Congenital Generalized Lipodystrophy (CGL). Patients are at significant risk of developing metabolic problems that include elevated triglycerides, severe insulin resistance, and impaired glycemic control, and abnormalities in multiple organs. We report a case of 16-year-old Emirati female with CGL with special focus on reversal of...

hrp0094p1-37 | Fat, Metabolism and Obesity A | ESPE2021

The effect of trans-palmitoleic acid on lipid accumulation and the fatty acid synthase gene expression in hepatocytes

Nourbakhsh Mitra , Farokh-Nezhad Ramesh , Razzaghy-Azar Maryam , Sharifi Roya , Yaghmaei Parichehreh , Nourbakhsh Mona ,

Introduction: Obesity is among the most prevalent health problems and is associated with increased risk of various metabolic disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Fatty acids comprise a major part of the lipids and have remarkable effect on cell biology. Trans fatty acids (tFAs) are generally a by-product of manufacturing of fats. However, naturally-produced tFAs that are found in milk and dairy products, are sugge...

hrp0094p1-38 | Fat, Metabolism and Obesity A | ESPE2021

Are Serum Spexin Levels Associated With Metabolic Syndrome Antecedents In Obese Adolescents?

Gulderen Kalay Şenturk Nida , Cakır Aydilek Dağdeviren , Yıldırmak Zeynep Yıldız , Ucar Ahmet ,

Objective: Spexin is a novel peptide implicated in food intake and satiety. Spexin levels are reduced in obese patients.Aim: To evaluate the associations of metabolic syndrome (metS) antecedents with serum spexin levels in obese adolescents.Setting: A university- based tertiary care centre.Patients and methods: Eighty consecutive obese adolescents aged 10-18 y and 80 healthy ...

hrp0094p1-39 | Fat, Metabolism and Obesity A | ESPE2021

Serum endocan as a predictive biomarker of cardiovascular risk in obese pediatric patients

Curatola Selenia , Mandraffino Giuseppe , Morace Carmela , Scuruchi Michele , Serrano Angela Elvira , Tropeano Angelo , Wasniewska Malgorzata , Valenzise Mariella ,

Introduction: Endocan is a soluble dermatan sulfate PG (50kDa), composed by 165 amino acid core protein, that is expressed and secreted by endothelial cells of dermal microvasculature, coronary, pulmonary arteries, and capillaries from adipose tissue. It plays an important role in the pathogenesis of vascular disorders, inflammation, and neoangiogenesis. Endocan biosynthesis is upregulated by inflammatory cytokines like TNF-α,IL-1, TGF-β1, and by pro...

hrp0094p1-40 | Fat, Metabolism and Obesity A | ESPE2021

Liraglutide for the Management of Childhood Obesity

Apperley Louise , Erlandson-Parry Karen , Gait Lucy , Laing Peter , Senniappan Senthil ,

Introduction: The prevalence of childhood obesity is continuing to increase worldwide and has become a major health concern. There are a number of serious complications to childhood obesity with significant long-term health implications if not managed in a timely matter. These complications include type 2 diabetes mellitus (T2DM), obstructive sleep apnoea (OSA), idiopathic intracranial hypertension (IIH) and non-alcoholic fatty liver disease (NAFLD). At presen...