hrp0098p3-240 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2024

Delayed puberty: etiological and gender characteristics

Latyshev Oleg , Velmakina Nadejda , Kiseleva Elena , Okminyan Goar , Romaikina Daria , Samsonova Lubov

Delayed puberty is a common condition defined as the lack of sexual maturation by an age ≥ 2 sd above the population mean.Materials and Methods: to study the structure of the delayed puberty (DP), 96 medical records of patients who were examined in the endocrinology department between 2020 and 2024 were selected: 77 boys (14.8 ± 1.23 years), 19 girls (14.5 ± 2.03 years) by querying the electronic information system of the medica...

hrp0092p1-133 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Congenital Disorders of Reproductive Hormones in Mini-puberty Boys with Bilateral Cryptorchidism

Raygorodskaya Nadezda , Bolotova Nina

Background: cryptorchidism is associated with the high risk of infertility. In some cases it may be the one of the first symptom of congenital hypogonadism. The period of 0 – 6 month of life is a short window for postnatal testicular maturation and the diagnostic of reproductive disorders.Objective: to evaluate the functional condition of pituitary and gonads in mini-puberty boys with bilateral cryptorchidism.<p...

hrp0084p2-506 | Perinatal | ESPE2015

Mini-Puberty in Boys with Cryptorchidism

Raygorodskaya Nadezda , Bolotova Nina

Background: The period of transitory postnatal activation of the hypothalamo-pitutary-gonadal axis (mini-puberty) plays an important role in the testicular maturation.Objective and hypotheses: To evaluate the functional condition of the gonads in 1–3 months boys with cryptorchidism.Method: 40 boys ages 1–3 months with cryptorchidism were examined: group 1–30 boys with unilateral inguinal retention testis and group 2&...

hrp0095p2-187 | Growth and Syndromes | ESPE2022

Combination Down / Klinefelter syndrome - a Clinical Case

Koleva Reni , Popov Borislav , Nadegda Dimitrova , Ana Grigorova , Valeria Petrova

Introduction: The combination Down/Klinefelter syndrome was first described in 1959 by Ford. Its frequency is 0.4-0.9 / 10,000 newborn boys.Case presentation: A boy aged 5 y 4 m, born from a 2nd high-risk pregnancy (mother aged 44 with 1st pregnancy resulting in spontaneous abortion at 12 gestational weeks and with twice-established anemic syndrome) with (+) biochemical screening for Down syndrome. Birth was given via pl...

hrp0089p2-p362 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Mini-Puberty in Boys with Inguinal Cryptorchidism

Raygorodskaya Nadezda , Bolotova Nina , Cherednikova Kseniya , Filina Nataliya , Nikolaeva Nataliya

Background: The period of 0–6 month of life is a short window for postnatal testicular maturation and the diagnostic of reproductive disorders.Objective: To evaluate the functional condition of the hypothalamo-pitutary-gonadal axis in 1–3 months boys with cryptorchidism.Method: 51 boys ages 1–3 months with cryptorchidism were examined: group 1–30 boys with unilateral inguinal retention testes and group 2–21...

hrp0086p2-p390 | Gonads &amp; DSD P2 | ESPE2016

Three Cases of NR5A1 (SF1) Gene Mutations in DSD Patients

Raygorodskaya Nadezda , Bolotova Nina , Kolodkina Anna , Dronova Elena

Background: NR5A1 mutations in DSD patients result in a wide range of clinical manifestations.Objective and hypotheses: To evaluate the clinical variability of ambiguous phenotypes and the gender assignment in DSD patients with SF1 mutations.Method: Clinical examination, hormonal tests, ultrasound, laparoscopy and molecular analyses, including direct and parallel sequencingResults: Case 1. A girl, aged 18 mon...

hrp0095p2-112 | Fat, Metabolism and Obesity | ESPE2022

Prediabetes in Obesity Adolescents: Frequency, Structure, Relationship with Body Mass Index

Minkova Nadezda , Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Romaykina Daria , Samsonova Lubov

Background: The increased prevalence of youth obesity has led to raised youth-onset type 2 diabetes mellitus (T2DM), as well as the intermediate condition of prediabetes. Diagnosis of prediabetes can help preventing of the development of T2DM.Aims: to study the frequency, clinical laboratory diagnostics and relationship of prediabetes with SDS BMI in obese adolescents.Materials: Th...

hrp0098p3-59 | Diabetes and Insulin | ESPE2024

Comparative characterization of prediabetes and diabetes mellitus type 2 in adolescents with obesity

Minkova Nadezda , Latyshev Oleg , Kiseleva Elena , Romaykina Daria , Okminyan Goar , Samsonova Lubov

Background: The development of diabetes mellitus type 2 (T2DM) involves a disbalance between pancreatic β-cell function and insulin sensitivity. The impact and sequence of pathological mechanisms involved in the development of T2DM in adolescents haven’t been established.Aims: To compare the role of pancreatic β-cell dysfunction and insulin resistance in the development of prediabetes and T2DM in obese ad...