ESPE Abstracts

Background: Emotional disorders are serious complications in obese children. Dopamine is known to be one of the neurotransmitters, which is in charge of such conditions.Aim: To determine neuroendocrine and psychological status in obese children.Methods: We examined 296 children in the Endocrinological Department of University Hospital (Minsk); group 1 – 206 obese children (simple obesity: 14.35±2 years; BMI 30.8±2.5 ...

Aim: To identify early risk factors of the development of alimentary obesity in adolescence.Methods: We analysed retrospectively 375 histories of development of adolescents: group 1 – 206 obese children (14.55±2.06 years, BMI 32.9±5.1 kg/m2), group 2 – 169 normal-weight patients (12.6±2.2 years (P=0.2); BMI 20.5±1.2 kg/m2 (P=0.0001)) from the University Hospital (Minsk). We collected a...

We present a 10 years old boy, born from normal pregnancy, weght 3300 gr, lenght 51 cm. Normal motor and intellectual development. Family history for short stature - mother's height 150.3 cm (P2), target height 174.3 cm (P37). At 7 years of age the patient's height was 108.9 cm (- 2.4 SD) - below the target range. Bone age was delayed with more than -2 SD. Two stimulation tests for growth hormone (GH) assessment have been performed (with insulin and glucagon) –...

Background: Autoimmune polyglandular syndrome type 1 (APS-1) is а rare multisystem disorder due to mutations in the autoimmune regulator gene (AIRE). APS-1 usually is characterized by a triad of hypoparathyroidism, primary adrenal insufficiency (PAI) and chronic mucocutaneous candidiasis. In the absence of the classic triad, the diagnosis becomes obscure and is often delayed.Case presentation: We report a 12 years ol...

Adrenoleukodystrophy is an X-linked, inherited metabolic disorder. Here, we present 3 clinical cases of different phenotypes with one mutation in ABCD1 gene in one family.Patient 1: At the age of 9 years, manifestation of neurological symptoms was observed, skin color changed, these symptoms progressed monthly. MRI of the brain showed 13 points on Loes scale.During the examination, the diagnosis of X-linke...

Background: Increased caloric intake in dietary obesity (DO) could be driven by central mechanisms regulating reward-seeking behavior. Leptin modulates the mesolimbic dopamine system and vice versa.Objective and hypotheses: We supposed D2 dopamine receptor agonists to influence weight gain and leptin level in genetically unmodified rats (GUR) with high caloric diet (HCD) as dietary obesity.Method: Male rats (n=48,...

Background: Congenital hyperinsulinism (CHI) is the most common cause of neonatal persistent hypoglycaemia. Current treatment lacks efficiency, and so are methods for differential diagnosis of diffuse and focal histological forms. Novel diagnostic and treatment approaches with the use of another hormone – glucagon-like-peptide-1 (GLP-1) – have been developed. GLP-1 is one of the key factors for maintaining euglycaemia. It stimulates insulin secretion...

Background and Aims: Initial presentation of type 1 diabetes (T1D) is associated with different level of diabetic ketoacidosis (DKA). Four pancreatic islet cell autoantibodies (Abs) mostly associate with T1D - glutamic acid decarboxylase antibodies (anti-GAD65), tyrosine phosphatase antibodies (IA 2-Ab), insulin autoantibody (anti-IAA) and zinc transporter 8 antibodyAim: To evaluate the prevalence of DKA, the frequency o...

Background: Non-classic congenital adrenal hyperplasia (NCCAH) is a genetic disorder characterized by hyperandrogenism associated with potential metabolic alterations and changes in body composition and bone mineral parameters.Aim: The purpose of this pilot study was to evaluate the clinical and biochemical characteristics in association with bone mineral parameters and body composition in female patients diagnosed with ...

Introduction: Prader-Willi syndrome (PWS) is a rare imprinting disorder with evidence of increasing incidence. Treatment with recombinant human growth hormone (rhGH) has been shown to improve growth, body composition and final height. It is officially approved by the US Food and Drug Administration since 2000, but still not official indication in many countries.Aim: The aim of the current study is to assess the results o...