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ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Fat Metabolism & Obesity (1)

hrp0082p2-d2-374 | Fat Metabolism & Obesity (1) | ESPE2014

The Role of Bone and Fat Tissue in Glucose Metabolism in Two Different Metabolic Conditions: Obesity and Diabetes Mellitus Type 1: Pilot Study

Wedrychowicz Anna , Sztefko Krystyna , Starzyk Jerzy

Background: Recent studies have shown a new link between skeleton, fat tissue, and insulin action. However, clinical data are still limited, especially in children.Objective: The aim of the presented study was to investigate the relationship between bone and fat hormones and glucose metabolism in children with type 1 diabetes mellitus (T1DM) and obesity.Methods: Forty-six T1DM children, mean age 12.2±4.6 years, mean BMI 20.0&#...

hrp0082p2-d2-375 | Fat Metabolism & Obesity (1) | ESPE2014

Family and Genetic Factors Influence the Metabolic Changes in Children

Solntsava Anzhalika , Viazava Liudmila , Sukalo Alexander , Aksionava Elena , Danilenko Nina

Background: Primary and secondary prevention of childhood obesity is an essential public health priority.Objective and hypotheses: To determine relationships between families, genetic and metabolic obesity risk factors in children.Method: 782 children (204 lean/578 obese; m/f=414/368) aged from 2 to 17.9 years were examined and classified in line with the pubertal stage: 392 prepubertal, 141 early, and 249 late puberty. Family hist...

hrp0082p2-d2-376 | Fat Metabolism & Obesity (1) | ESPE2014

Non-Alcoholic Fatty Liver Disease in Children/Adolescent Affected by Prader–WIlli Syndrome

Fintini Danilo , Inzaghi Elena , Bocchini Sarah , Grugni Graziano , Colajacomo Mauro , Brufani Claudia , Cappa Marco , Nobili Valerio , Cianfarani Stefano , Crino Antonino

Background: Prader–Willi syndrome (PWS) has a relative hypoinsulinemia and a lower insulin resistance than non-PWS subjects. Mostly on the basis of such higher insulin sensitivity, PWS subjects have been hypothesized to be at lower risk of non-alcoholic fatty liver disease (NAFLD).Objective and hypotheses: In this cross-sectional study, we analyzed the presence and the severity of NAFLD in a group of PWS children compared to matched pairs.<p cla...

hrp0082p2-d2-377 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Short-Term Results of Single-Port Sleeve Gastrectomy in Adolescents with Severe Obesity

De Filippo Gianpaolo , Pourcher Guillaume , Piquard Catherine , Ferretti Stefano , Dagher Ibrahim , Bougneres Pierre

Background: Dietary and lifestyle modifications commonly proposed to overweight or obese youth lack efficacy in those with severe obesity. Early results with bariatric procedures in obese adolescents suggest that weight loss and safety are comparable or better than those seen in adults. One of these procedures, laparoscopic sleeve gastrectomy, is commonly performed using multiple ports. We selected single port sleeve gastrectomy (SPSG) as a minimally invasive surgery to be tes...

hrp0082p2-d2-378 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Circulating Concentrations of Fibroblast Growth Factor 21 are Undetectable in Human Infants at Term Birth and Surge within Hours After Birth

Sanchez-Infantes David , Gallego-Escudero Jose Miguel , Cereijo Ruben , Diaz Marta , Aragones Gemma , Lopez-Bermejo Abel , de Zegher Francis , Villarroya Francesc , Ibanez Lourdes

Background: In rodents, fibroblast growth factor 21 (FGF21), an endocrine member of the FGF family, is mainly produced in the liver and promotes glucose oxidation in several tissues; the circulating concentrations of FGF21 rise shortly after birth. In the human, the ontogeny of circulating FGF21 is essentially unknown.Objective and hypotheses: To assess whether there is also a neonatal surge of circulating FGF21 concen...

hrp0082p2-d2-379 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Severe Childhood-Onset Obesity and Testicular Function After Puberty

Laakso Saila , Viljakainen Heli , Lipsanen-Nyman Marita , Turpeinen Ursula , Saukkonen Tero , Makitie Outi

Background: Obesity has in males been associated with reduced testosterone levels during and after puberty. However, the onset and progress of puberty into fertility in obese boys remain inadequately evaluated.Objective and hypotheses: We aimed to study testicular function at the end of pubertal development (15–24 years) in males with severe childhood-onset obesity (height-adjusted relative weight exceeding 160% before the age of 7 years).<p cla...

hrp0082p2-d2-380 | Fat Metabolism &amp; Obesity (1) | ESPE2014

A New Case of Proopiomelanocortin Deficiency

Fuentes-Bolanos Noemi Auxiliadora , Madueno Francisco Jose Tinahones , Gonzalez Luis Castano , Gea Isabel Leiva , Ollero Maria Jose Martinez-Aedo , Lopez-Siguero Juan Pedro

Introduction: The proopiomelanocortin is a polypeptide of many biologically active peptides involved in many key functions which have not yet been clarified. The mutation in the gene encoding this polypeptide is associated with a clinical trials characterized by early-onset obesity, terciary adrenal insufficiency, and alteration of pigmentation. Eight cases with known genetic mutation have been published.Case report: Newborn male 27 days old from North A...

hrp0082p2-d2-381 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Neuroendocrine and Psychological Status in Obese Children

Solntsava Anzhalika , Zagrebaeva Olga , Yemelyantsava Tatsiana , Mikhno Hanna , Dashkevich Helena , Tkachova Yuliya

Background: Emotional disorders are serious complications in obese children. Dopamine is known to be one of the neurotransmitters, which is in charge of such conditions.Aim: To determine neuroendocrine and psychological status in obese children.Methods: We examined 296 children in the Endocrinological Department of University Hospital (Minsk); group 1 – 206 obese children (simple obesity: 14.35±2 years; BMI 30.8±2.5 ...

hrp0082p2-d2-382 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Is 24-h Blood Pressure Monitoring Necessary in Obese Children and Adolescents?

Wojcik Malgorzata , Malek Jadwiga , Janus Dominika , Kalicka-Kasperczyk Anna , Tyrawa Katarzyna , Starzyk Jerzy B

Background: Arterial hypertension (AH) is one of the most common and the earliest complications of childhood obesity. It is diagnosed on the basis of at least three results of the standard setting measurements of systolic (SBP) and diastolic (DBP) blood pressure. Nevertheless, some data suggest, that this diagnostic standard may be not sufficient for obese children, because some BP abnormalities, unique for these patients, (decrease of night dip, elevated SBP/DBP load) cannot ...

hrp0082p2-d2-383 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Fetuin A Serum Levels in Children with Nonalcoholic Fatty Liver Disease

Pampanini Valentina , Inzaghi Elena , Nobili Valerio , Germani Daniela , Puglianiello Antonella , Cianfarani Stefano

Background: Fetuin A is a hepatokine known as a natural inhibitor of the insulin receptor tyrosine kinase and is associated with insulin resistance and nonalcoholic fatty liver disease (NAFLD). Studies on adults provided conflicting results regarding the link between fetuin A and the severity of liver damage in NAFLD. Data on children are limited.Objective: To investigate the relationship between fetuin A, metabolic parameters, and NAFLD in obese childre...

hrp0082p2-d2-384 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Ambulatory Arterial Stiffness Index in Obese Children

Saner Christoph , Mullis Primus , Simonetti Giacomo , Janner Marco

Background: Altered arterial stiffness is a recognized risk factor of poor cardiovascularhealth. Ambulatory arterial stiffness index (AASI, defined as one minus the regression slope of diastolic on systolic blood pressure values derived from a 24 h arterial blood pressure monitoring (ABPM)) is an upcoming and readily available marker of arterial stiffness. We tested the hypothesis that AASI is increased in obese children compared to healthy subjects.Meth...

hrp0082p2-d2-385 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Evaluation of the Risk of Dyslipidemia in Adolescents with Obesity

Gailite Jurgita , Urbane Urzula Nora , Strele Ieva , Erts Renars , Lauga-Tunina Una , Kirillova Inara , Gardovska Dace , Dzivite-Krisane Iveta

Introduction: Abnormal levels of lipids and lipoproteins are recognized as a prominent cardiovascular risk factor associated with increased morbidity and mortality. In many studies childhood obesity has been shown to be associated with increased levels of total cholesterol (TH), triglycerides (TG), LDL-cholesterol, and decreased levels of HDL-cholesterol.Objective: The aim of this study was to evaluate the risk of dyslipidemia (abnormal levels of all of ...