Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

Card image cap
Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Fat Metabolism & Obesity

hrp0082p2-d1-362 | Fat Metabolism & Obesity | ESPE2014

Age at Onset of Weight Gain in Prader–Willi Syndrome is Often Between 1 and 2 Years, Preceding the Hyperphagic Phase; Implications for Management

Donaldson Malcolm , Hammed Noran Abu-Of , Shaikh M Guftar

Background: Prader–Willi syndrome (PWS) results from loss of paternally imprinted genes from the 15q11–13 region and causes hypotonia with weight faltering in infancy, followed later by obesity which is classically attributed to hyperphagia.Objective and hypotheses: To determine, where possible, the age at onset of unwanted weight gain (as opposed to actual obesity) in children with PWS attending a specialist clinic.Metho...

hrp0082p2-d1-363 | Fat Metabolism & Obesity | ESPE2014

Novel Uncoupling Protein 1 Expression in White Adipocytes of Subcutaneous Abdominal Adipose Tissue in Children and Adolescents: A Protective Mechanism for Metabolic Equilibrium?

Karvela Alexia , Avgeri Aikaterini , Vlotinou Eleni D , Georgiou George , Papachristou Dionysios J , Spiliotis Bessie E

Background: Morbid childhood obesity predisposes to metabolic disorders such as diabetes type 2. In mice, heat-producing ‘brown-like’ (beige) adipocytes can suppress weight gain and metabolic disease through the action of uncoupling protein 1 (UCP1) localized in the mitochondria.Objective and hypotheses: To study the expression of UCP1 in the adipose tissue of lean&obese children and adolescents.Method: Paraffin embed...

hrp0082p2-d1-364 | Fat Metabolism & Obesity | ESPE2014

The Association Between Self-Reported Sleep Quality, Ghrelin Hormone and Obese Children and Adolescents

El-Ashmawy Abeer , Eyada Iman , Mohamed Nahed , Attya Mona , Abdel-Ghaffar Shereen , Farouk Marwa

Background: Sleep quality, ghrelin hormone and obesity are associated with metabolic syndrome.Objective and hypotheses: To study associations between sleep duration, level of ghrelin and obesity in children and adolescents.Method: A prospective study was conducted on 50 children (their mean age: 8.7±3.2 years) with simple exogenous obesity (BMI SDS >2) recruited from Diabetes Endocrine and Metabolism Pediatric Unit, Childr...

hrp0082p2-d1-365 | Fat Metabolism & Obesity | ESPE2014

Large-Born Infants Switch from an Adipose to a Lean and Insulin-Sensitive State with Low Concentrations of Circulating Myostatin and Follistatin

Sebastiani Giorgia , Cruz Miriam Perez , Silva Marta Diaz , Roig Maria Dolores Gomez , Bermejo Abel Lopez , Toda Lourdes Ibanez , De Zegher Francis

Background: Muscle is key to glucose metabolism. Myogenesis is completed in early infancy, partly under the inhibitory control of myostatin, a myokine whose actions can be influenced by follistatin. Early lowering of myostatin actions is thus a potential strategy to reduce the risk for later diabetes.Objective and hypotheses: We performed a first screening of whether such lowering is among the natural mechanisms whereby some human infants augment their l...

hrp0082p2-d1-366 | Fat Metabolism & Obesity | ESPE2014

Uric Acid and Risk for Atherosclerotic Disease Early in Life

Bassols Judit , Martinez-Calcerrada Jose-Maria , Prats-Puig Anna , Carreras-Badosa Gemma , Diaz-Roldan Ferran , Osiniri Ines , Riera-Perez Elena , de Zegher Francis , Ibanez Lourdes , Lopez-Bermejo Abel

Background: Increased uric acid is an independent risk factor for cardiovascular disease in obese adults and adolescents. The relationship between uric acid and atherosclerotic risk early in life is unknown.Objective and hypotheses: We investigated whether uric acid relates to carotid intima–media thickness (cIMT), a marker of preclinical atherosclerosis, in a rather large sample of school-age children and investigated the interaction of obesity sta...

hrp0082p2-d1-367 | Fat Metabolism & Obesity | ESPE2014

Prevalence of Idiopathic Intracranial Hypertension and Related Factors in Obese Children and Adolescents

Tepe Derya , Demirel Fatma , Seker Esra Dag , Tayfun Meltem , Esen Ihsan , Kara Ozlem , Arhan Ebru Petek

Background: Idiopathic intracranial hypertension (IIH) is a disorder of elevated intracranial pressure without any evidence of intracranial pathology or underlying systemic disease. Obesity was reported as a significant cause of IIH in childhood especially in adolescents.Objective and hypotheses: IIH is a disorder of elevated intracranial pressure without any evidence of intracranial pathology or underlying systemic disease. Obesity was reported as a sig...

hrp0082p2-d1-368 | Fat Metabolism & Obesity | ESPE2014

MAINTAIN: an Intervention Study of Weight Regain After Weight Loss in Adolescents and Children Reveals an Only Minor Role of Leptin in Weight Regain

Wiegand Susanna , Bau Anne-Madeleine , Ernert Andrea , Krude Heiko

Background: Lifestyle interventions show a long lasting weight reduction in only 10–20% of obese children and adolescents. Leptin as one major player within the central regulation of food intake and energy expenditure is most likely to mediate the endogenous drive for weight regain.Objective and hypotheses: To estimate weight regain after weight loss and the role of leptin in regain.Method: We included 153 obese children/adole...

hrp0082p2-d1-369 | Fat Metabolism & Obesity | ESPE2014

The Expression of IGF Type 1 Receptor is Increased in Obese Children

Ricco Rafaela , Custodio Rodrigo , Atique Patricia , Liberatore Raphael , Ricco Rubens , Martinelli Carlos

Background: Obese children are often taller than non-obese ones before puberty. Reports on the GH/IGF system in obese children are not consistent and do not explain the increased height observed. Changes in IGF1 bioavailability/bioactivity have been claimed as a possible explanation, however, no data is available regarding the expression of the IGF type 1 receptor (IGF1R) gene.Objective and hypotheses: To study the expression of IGF1R gene in obese child...

hrp0082p2-d1-370 | Fat Metabolism & Obesity | ESPE2014

Childhood Obesity, Renal Injury, and Future Disease Risk

Lateva Mina , Bliznakova Dimitrichka , Galcheva Sonya , Neshkinska Maria , Mladenov Vilhelm , Boyadzhiev Veselin , Halvadzhiyan Irina , Yordanova Galina , Iotova Violeta

Background: Evidence associates obesity with glomerular hyperperfusion. Concurrent inflammation, hypertension, dyslipidemia, and insulin resistance represent further established risks to renal health in both children and adults.Objective and hypotheses: To investigate the relationship between childhood obesity and risk of renal impairment.Method: A total of 114 (38.6% boys) obese according to the IOTF reference but otherwise health...

hrp0082p2-d1-371 | Fat Metabolism & Obesity | ESPE2014

Replacement of the Neonatal Leptin Surge During Maternal Deprivation Normalizes Some Endocrine Parameters but Exacerbates Others

Mela Virginia , Lopez-Rodriguez Alvaro , Penasco Sara , Barrios Vicente , Argente Jesus , Viveros Maria-Paz , Chowen Julie A

Introduction: Maternal deprivation (MD) during neonatal life has diverse long-term effects, including modification of metabolism. Some of these effects are sexually dimorphic. We have previously reported that MD in rats blocks the physiological neonatal leptin surge, which could underlie the long-term metabolic changes.Hypothesis: We hypothesized that replacement of leptin during MD would normalize long-term endocrine changes.Metho...

hrp0082p2-d1-372 | Fat Metabolism & Obesity | ESPE2014

Longitudinal Development of Adiponectin in Early Childhood and the Influence of Breastfeeding and Essential Fatty Acid Status

Roswall Josefine , Kjellberg Emma , Strandvik Birgitta , Dahlgren Jovanna

Background: Adiponectin is an adipokine related to insulin sensitivity. In adults and older children adiponectin correlates inversely to BMI, insulin resistance, and cardiovascular risk. Less is known about these relationships in early childhood.Objective and hypotheses: To explore the longitudinal development of adiponectin and correlations to early feeding patterns and serum essential fatty acids.Method: 324 term infants were fol...

hrp0082p2-d1-373 | Fat Metabolism & Obesity | ESPE2014

Expression Levels of the Growth-Arrest-Specific Transcript 5 in Overweight and Obese Children and Adolescents

Fragouli Terpsihori , Sertedaki Amalia , Farakla Ioanna , Nicolaides Nicolas C , Dracopoulou Maria , Papassotiriou Ioannis , Chrousos George P , Charmandari Evangelia

Background: The noncoding RNA growth-arrest-specific transcript 5 (Gas5) is abundant in cells whose growth has been arrested owing to lack of nutrients or growth factors. Gas5 is a riborepressor of the glucocorticoid receptor, influencing cell survival and metabolic activities during starvation by inhibiting the latter’s transcriptional activity.Aim: To determine the expression levels of Gas5 in blood samples of obese, overweight and lean children a...