hrp0084p3-1157 | Puberty | ESPE2015

Assessment of Endocrine Function in Egyptian Adolescent B-Thalassemia Major Patients

Dayem Soha Abd El , Kader Mona Abd El

Objective: To evaluate the endocrine function among Egyptian adolescent thalassemic patients.Patients and methods: 54 patients and 28 age-matched normal controls was included. Anthropometric measurements, clinical pubertal assessment were done for all patients. Oral glucose tolerance test (OGTT) was done to all patients and controls with measuring serum insulin level at 0.120 minutes. Insulin sensitivity and release index were calculated. 32 patients had...

hrp0084p3-720 | Diabetes | ESPE2015

Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient

Battah Ahmed , Dayem Soha Abd El , Bohy Abo El Magd El , Allah Nagwa Abd

Objective: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification.Patients and methods: It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 h holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. t-test, Mann–Whitney U-test ...

hrp0084p3-724 | Diabetes | ESPE2015

Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycaemic Control and Complication of Diabetes

Dayem Soha Abd El , Nazif Hayam K , Kader Mona Abd El , El-Tawil Maha , Battah Ahmed

Objective: To determine the influence of adolescent girls with type 1 DM on circulating levels of adiponectin and to study the relation between adiponectin level with glycemic control and complication of diabetes.Patients and methods: The study included 40 female adolescent type 1 diabetic patients and 40 healthy volunteer of the same age and sex. Blood sample was taken for assessment of glycosylated haemoglobin, lipid profile and adiponectine. Urine sam...

hrp0089p3-p417 | Diabetes & Insulin P3 | ESPE2018

Study of Children with Type 1 Diabetes Mellitus of Long Duration Attending Alexandria University Children’S Hospital

Fawzy Dina , Elsayed Shaymaa , Abd El-Moneim Mahmoud

Background: Type 1 diabetes mellitus (T1DM) is a complex metabolic disorder typically diagnosed in childhood and characterized by insufficient insulin production. Diabetic complications are still a major concern as they constitute the main cause of morbidity and mortality in diabetic patients despite the advances in T1DM treatment. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy ...

hrp0084p3-769 | Diabetes | ESPE2015

Cutaneous Manifestations among Type 1 Diabetic Patients in DEMPU

Youssef Randa , Ibrahim Amany , Amin Iman , Naser Amany Abd El

Background: Almost all diabetic patients eventually develop skin complications from the long-term effects of diabetes mellitus. Cutaneous manifestations generally appear subsequent to the development of diabetes but may be the first presenting sign, or even precede the diagnosis.Objective and hypotheses: To detect the prevalence and spectrum of skin manifestations in type 1 diabetic (T1D) patients attending the Diabetes Endocrine and Metabolism Pediatric...

hrp0084p2-253 | Diabetes | ESPE2015

Value of the Intrarenal Arterial Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients

Battah Ahmed , Dayem Soha Abd El , Bohy Abo El Magd El , Shohaby Amal El , Allah Nagwa Abd

Objective: To compare resistivity index (RI) in type 1 diabetic patients and normal controls, secondly to evaluate whether high RI is associated with different biomarkers of diabetic nephropathy (DN) as early detection of DN offers the best chance of delaying or possibly preventing progression to end-stage renal disease.Patients and methods: The study included 62 type 1 diabetic patients and 30 healthy volunteer of the same age and sex. Blood sample was ...

hrp0084p3-764 | Diabetes | ESPE2015

The Role of KCNJ11 Gene in Neonatal Diabetes

El Dayem Soha Abd , Shawky Shereen , Kader Mona Abd El , Kamel Solaf , Khalifa Rania Hassan , Lebedy Dalia El , Ahmed Dina

Background: Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of life. Infants with NDM do not produce enough insulin, leading to hyperglycaemia. An identified and potentially treatable form of monogenic diabetes is the neonatal diabetes caused by activating mutations of the KCNJ11 gene, which codes for the Kir6.2 subunit of the beta cell of the ATP sensitive potassium channel (KATP). The identification of KCNJ11 mutation has im...

hrp0095p1-441 | Diabetes and Insulin | ESPE2022

NEUROD1 mutation as a cause of neonatal diabetes: the rarest of the rare!

Abdelmeguid Yasmine , Elwan Samar , De Franco Elisa , Abd Elmaksoud Marwa , Khater Doaa

Background: NEUROD1 encoding neurogenic differentiation 1 is known to play an important role in the development of the pancreas and central nervous system. Heterozygous mutations have been rarely identified as a cause of maturity-onset diabetes of the young (MODY6). Biallelic NEUROD1 mutations have been reported to cause neonatal diabetes mellitus (NDM) as well. However, only 3 cases have been reported worldwide so far....

hrp0092p2-33 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Growth and Bone Mineral Density in Egyptian Children with Congenital Adrenal Hyperplasia on Glucocorticoid Replacement Therapy; A Single Center Study

Magdy Omar Omneya , Elsayed Shaymaa , Abokhashaba Mohamed , Abd El Fattah Magdy

Background: Children with congenital adrenal hyperplasia (CAH) need chronic glucocorticoid therapy, both to replace congenital deficit in cortisol synthesis and to suppress the overproduction of androgens by the adrenal cortex. High doses of glucocorticoid taken chronically might affect bone metabolism and lead to alterations of bone mass in this condition. In particular, they could increase bone resorption rate. Bone mineral density (BMD) by energy X-ray abso...

hrp0092p2-258 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Study of Autistic Features Among Children and Adolescents with Congenital Adrenal Hyperplasia

Elsayed Shaymaa , Omar Tarek , El Bardeny Magdy , El-Latif Soha Abd , Ibrahim Sandra

Introduction: Autism spectrum disorder (ASD) consists of a pattern of persistent deficits in social communication and interaction across multiple contexts together with restricted, repetitive patterns of behavior, interests or activities. In the general population autistic traits can be found more frequently in males than females. This male predominance indicates that high androgen levels may prenatally have influence on development of autistic traits.<p c...