hrp0097p2-288 | Late Breaking | ESPE2023

Validation of utility of a single LH measurement 40 minutes after depot Leuprolide acetate 3.75 mg and 11.25 mg in assessing gonadotropic activity in girls with CPP: Comparison with a standard GnRH stimulation test at diagnosis and during treatment.

Helvacıoğlu Didem , Demircioğlu Serap , Güran Tülay , Haliloğlu Belma , Türkmen Nilsu , Gurpınar Tosun Buşra , Kahveci Ahmet , Bereket Abdullah

Context: Intravenous Gonadotropin-Releasing-Hormone (GnRH) stimulation test has a central role in evaluating gonadotropic activation in the diagnosis and monitorization of the treatment in patients with central precocious puberty (CPP). However, this test is invasive, laborious, costly and availability of GnRH preparation is limited in some countries.Objective: To evaluate the utility of the LH level measured 40-minutes ...

hrp0098p2-42 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

The etiological distribution of elevated serum alkaline phosphatase levels and characteristics of children with transient hyperphosphatasemia

Bahar Balaban Berber İlkay , Öztürk Sercan , Güneş Sebla , Tekneci Ayşegül , Ünüvar Tolga , Anik Ahmet

Objective: Elevated serum alkaline phosphatase (ALP) levels in pediatric patients can result from various etiologies, with transient hyperphosphatasemia, bone pathologies, and hepatic diseases being the most common. This study aimed to elucidate the etiological factors responsible for elevated ALP levels and to evaluate the clinical presentations of transient hyperphosphatasemia in these patients.Materials and Methods: T...

hrp0098p2-69 | Diabetes and Insulin | ESPE2024

Venous Sodium, Potassium, and Glucose Results on Rapid Arterial Blood Gas Analyzer in Children with Diabetic Ketoacidosis: Are the Values Comparable with Results Obtained from the Central Laboratory?

Güneş Sebla , Öztürk Sercan , Şafak İlhan , Deveci Sevim Reyhan , Ünüvar Tolga , Anık Ahmet

Introduction: This retrospective study aim ed to assess the correlation between whole blood electrolytes measured by an arterial blood gas analyzer and serum electrolytes measured at a central laboratory, of patients with diabetic ketoacidosis (DKA).Materials and Methods: Children (1-18 years old) with DKA, followed up at Aydın Adnan Menderes University Faculty of Medicine Hospital between January 2017 and August 2...

hrp0098p2-71 | Diabetes and Insulin | ESPE2024

Severe Acute Kidney Injury in an Adolescent with Diabetic Ketoacidosis

Şen Küçük Kübra , Deveci Sevim Reyhan , Feray Arı Hatice , Ünüvar Tolga , Anık Ahmet

Introduction: Acute kidney injury (AKI) is a common complication in diabetic ketoacidosis (DKA). AKI in children with DKA is often mild and transient. Severe AKI is rare.Case: A 14-year-old female presented with symptoms consistent with recent-onset diabetes mellitus, accompanied by abdominal pain, vomiting, and respiratory distress over the preceding two days. Physical examination revealed confusion with a Glasgow Coma ...

hrp0098p2-324 | Late Breaking | ESPE2024

HOMA and Matsuda Index as Screening Tests for Cystic Fibrosis Associated Diabetes in Children

Albayrak Serpil , Arık Elif , Keskin Ozlem , Karaoglan Murat , Keskin Mehmet , Inal Gaye , Cesur Mahmut , Küçükosmanoğlu Ercan , Yıldırım Ahmet

Objective: Cystic fibrosis (CF) associated diabetes (CFRD) is a common comorbid condition in individuals with CF and its prevalence increases with age. There are reports in children aged 10 years and younger. The aimof this study was to estimate insulin resistance by HOMA-IR (Homeostatic Model Assessment) with oral glucose tolerance test (OGTT) data and Matsuda index to test glucose metabolism in relation to Matsuda insulin secretion in children with CF.<p...

hrp0098p2-298 | Late Breaking | ESPE2024

A real-world data analysis of 37 pediatric patients with pheochromocytoma and paraganglioma: Evaluation of the concordance between current diagnostic and treatment algorithms and clinical management practices in resource-limited settings

Kurt Ilknur , Gurpinar Tosun Busra , Gul Uslu Nihal , Ozalp Kizilay Deniz , Dikmen Ibrahim , Ozguc Comlek Fatma , Bugrul Fuat , Bezen Digdem , Hatipoglu Nihal , Dogan Murat , Deniz Papatya Cakir Esra , Ucar Ahmet , Ozcabi Bahar , Yildirim Cakar Didem , Hatun Aytac Kaplan Emel , Sutcu Zumrut , Nur Hepokur Merve , Catli Gonul , Ahmet Ucakturk S , Demir Senol , Siklar Zeynep , Haliloglu Belma , Turan Serap , Bereket Abdullah , Guran Tulay

Background: Pheochromocytomas and paragangliomas (PPGLs) are rare pediatric neuroendocrine tumors. Data on the diagnosis, treatment and follow-up of PPGL in children are limited and lack standardization. Furthermore, variations in access to diagnostic and therapeutic resources across centers contribute to inconsistencies in clinical management.Aim: To identify variations in the clinical management of paediatric PPGL with...

hrp0095p1-170 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Increased Circulating Levels of Myo-inositol in Girls with Polycystic Ovary Syndrome

Üçer Bahadır Nisan , Metin Güler Eray , Kale Ebru , Aktaş Selman , Dağdeviren Çakır Aydilek , Kocabey Sütçü Zümrüt , Esen Firuzan , Beyaztaş Hakan , İmran Daştan Ali , Uçar Ahmet

Background: Myo-inositol(MI)is a polyol involved in intracellular signaling pathways of insulin and MI has been used orally for therapeutic purposes in girls and adult women with polycystic ovary syndrome(PCOS)with variable success. As yet, serum MI levels have not been assessed in girls with PCOS.Aim: Our primary goal was to compare serum MI levels in girls with PCOS with those in healthy peers. Secondary goal was to in...

hrp0092p1-175 | Bone, Growth Plate and Mineral Metabolism (1) | ESPE2019

Rare Causes of Osteogenesis Imperfecta are Common in Consanguineous Pedigrees

Kaygusuz Sare Betul , Arman Ahmet , Abali Saygin , Ata Pinar , Kirkgoz Tarik , Eltan Mehmet , Abali Zehra Yavas , Helvacioglu Didem , Tosun Busra Gurpinar , Menevse Tuba Seven , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Osteogenesis imperfecta (OI) is characterized by low bone mass and bone fragility mainly due to COL1A1/COL1A2 gene defects. However, >17 genes have been identified in the pathogenesis of OI. Here, we aim to characterize genotypic spectrum of our OI cohort.Methods: Forty-nine OI patients (28 males) from 38 different families (13 consanguineous/9 multiplex) were screened with the next-gene...

hrp0089p2-p177 | Fat, Metabolism and Obesity P2 | ESPE2018

The Effects of the Birth Weight on the Fat Distribution and Fatness Parameters of the Body

Hatipoğlu Nihal , Direk Gul , Hepokur Merve Nur , Tatlı Zeynep Uzan , Cicek Betul , Unalan Demet , Mazıcıoğlu M. Mumtaz , Ozturk Ahmet , Kurtoğlu Selim

The weight of birth affects the weight status and fat distribution in the later period of life. It is suggested that both low and high birth weight pose a risk for cardiometabolic diseases. In this study, the effects of birth weight on body fat mass and body fat distribution parameters during childhood and adolescence period were evaluated.Method: In this cross-sectional study, 4581 children ages between 6-17 years at primary and secon...

hrp0084p3-642 | Bone | ESPE2015

Comparison of Treatment Alternatives for Hypercalcemia due to Vitamin D Intoxication in Children

Demir Korcan , Doneray Hakan , Yesilkaya Ediz , Kara Cengiz , Atay Zeynep , Cetinkaya Semra , Cayir Atilla , Anik Ahmet , Eren Erdal , Demirel Fatma , Yilmaz Gulay Can , Ergur Ayca Torel , Kendirci Mustafa , Aycan Zehra , Bereket Abdullah , Aydin Murat , Orbak Zerrin , Ozkan Behzat

Background: No large study comparing efficiency of prednisolone, alendronate and pamidronate has been conducted so far in children with hypercalcemia due to vitamin D intoxication.Objective and hypotheses: To perform a multicentre, retrospective study assessing clinical characteristics and treatment results.Method: A standard questionnaire was uploaded to an online national database system (www.favorsci.org) to collect data of chil...