ESPE Abstracts

Introduction: Insulin-like growth factor (IGF)-1, IGF binding proteins (IGFBPs) and regulatory metabolites, including cyclic Glycine-Proline (cGP), have a possible role in modifying infant growth trajectories through their effects on linear growth, and body composition. There is no consensus on how maternal BMI affects breast milk IGF1 level.Aim: We reviewed the recent literature about human milk (IGF)-1, and cGP concent...

Introduction: Accumulating evidence indicates various but significant effects of human milk IGF1 (HMIGF1) on infantile and childhood linear growth and weight gain. Studies on maternal factors affecting the level of HMIGF1 need to be clarified.Objectives and Methods: We performed electronic literature systematic review using PubMed, Google Scholar, and Web of Sciences with the aim to provide an update on maternal factors ...

Introduction: Breastfeeding is one of the most effective preventive measures of childhood obesity and many other chronic diseases. The effect of breastfeeding vs formula feeding in changing infant`s body composition remains unclear.Aim and Methods: The objective of this review is to update and summarize the recent literature (Pubmed, Google scholar, Scopus and Research gate in the past 10 years) on studies investig...

Introduction: Placental hormones can control the transfer of maternal nutrients to the fetus and modulate fetal and neonatal growth. Data about the interaction between maternal, placental and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research paper published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between maternal, placental and fetal/infant...

Introduction: Quality of life (QoL), comprises physical, psychological, environmental, and social aspects, is an index designed to measure the burden of chronic diseases and evaluate the treatment outcome. Thalassemia major (BTM) is a chronic disease in children that harms children QoL by interrupting physical function, emotional function, social function, and school function. ObjectivesAim: This study aims to identify t...

Introduction: Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition affects the growth, efficacy of treatments, and quality of life in children suffering from BTM.Objective: To evaluate the prevalence of malnutrition (BMI < 3rd centile for age and sex) or BMISDS < -2 in 10 Mediterranean and Middle east countries and the USA in the past 20 years.  <p c...

Introduction:Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). Malnutrition negatively affects their growth, efficacy of treatments, and quality of life.Objective: To evaluate the nutritional status and linear growth in 10 countries in the past 20 years.Methods: We performed an electronic search in PubMed, Google Scholar, and Web of Scie...

Background: Growth disorders in children often present a multifactorial challenge involving genetics, nutrition, and endocrine function. This case report focuses on a young girl with growth retardation linked to a homozygous pathogenic variant in the PAPPA2 gene, encoding pregnancy-associated plasma protein-A2 (PAPP-A2), a key regulator in the insulin-like growth factor 1 (IGF-I) axis.Case Presentation: A 5-year-old girl...

Introduction: The complex interplay between nutritional status, body mass index (BMI), and insulin-like growth factor-1 (IGF-1) is pivotal in understanding pediatric growth. Our study investigates these relationships to enhance growth outcomes in children.Objective: We aimed to evaluate the effects of nutritional interventions on BMI, height growth velocity, and IGF-1 levels in 125 underweight children aged 2-10, who und...

Introduction: Children born small for gestational age (SGA) are susceptible to abnormal glucose metabolism and insulin resistance, which may be exacerbated by (GH) therapy.Methods: A comprehensive analysis of existing literature was conducted to assess the outcomes and implications of GH treatment in this specific pediatric population.Results: 10 studies were reviewed, (1458 SGA ch...