hrp0098p2-143 | GH and IGFs | ESPE2024

Retrospective Analysis of Early Growth Patterns in Children Diagnosed with Growth Hormone Deficiency

Alyafei Fawzia , Soliman Ashraf , Abdulkayoum Anas , Ahmed Shayma , Hamed Noor , Elsiddig Sohair , Alaaraj Nada

Introduction: Growth Hormone Deficiency (GHD) in early childhood is a significant concern due to its impact on physical development. This retrospective study investigates the early growth patterns of children diagnosed with GHD during early childhood (average diagnosis age 5.2 years ± 1.1 years) to understand the progression of growth deviations in this population.Patients and Methods: Our study involved a retrospecti...

hrp0098p2-144 | GH and IGFs | ESPE2024

Growth Aberrations in a Yemeni Girl with Elevated IGF-1 Due to a PAPPA2 Gene Mutation: A Case Report

Elsiddig Sohair , Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Introduction: The PAPPA2 gene plays a crucial role in growth regulation through its interaction with the insulin-like growth factor (IGF) system. Mutations in this gene can lead to disrupted growth patterns. This case report describes the clinical course of a Yemeni girl with a pathogenic PAPPA2 variant, characterized by high IGF-1 levels and affected linear growth and weight gain.Case Presentation: A 5-year-old girl of ...

hrp0098p2-159 | Growth and Syndromes | ESPE2024

Correlation Patterns in Longitudinal Growth of Preterm AGA Infants with Birth Weight < 1.5 kg Over Five Years

Alyafei Fawzia , Soliman Ashraf , Abdulkayoum Anas , Alaaraj ada , Hamed Noor , Ahmed Shayma , Ali Hamdy

Background: Understanding the growth trajectories of preterm Appropriate for Gestational Age (AGA) infants with birth weights under 1.5 kg is crucial for optimizing their long-term health outcomes. This study explores the correlations between various growth parameters over five years to identify predictive markers for future growth.Methods: A longitudinal cohort study was conducted on preterm AGA infants (n = 50...

hrp0098p2-160 | Growth and Syndromes | ESPE2024

Early Growth Decline in Children with Growth Hormone Deficiency: A Comparative Study with Emphasis on Rapid Catch-Down Growth during early infancy.

Alyafei Fawzia , Soliman Ashraf , Abdulkayoum Anas , Ahmed Shayma , Hamed oor , Elsiddig Sohair , Alaaraj Nada

Introduction: Previous studies have demonstrated varying patterns of growth in children with Growth Hormone Deficiency (GHD), particularly in the first two years of life, a period crucial for growth and development. This study aims to compare the early growth patterns, specifically the rate of catch-down growth in the initial months post-birth, of children diagnosed with GHD. By juxtaposing our findings with existing literature, we seek to deepen the understan...

hrp0098p2-199 | Multisystem Endocrine Disorders | ESPE2024

Impact of Iron Chelation Therapy Adherence on Prediabetes Development in Young Adult β-Thalassemia Major Patients: A Comparative Analysis

De Sanctis Vincenzo , Soliman Ashraf , Daar Shahina , Campisi Saveria , Tzoulis Ploutarchos

Introduction: In β-Thalassemia major (β-TDT) the influence of consistent iron chelation therapy on prediabetes development remains uncertain.Objectives: To identify factors associated with prediabetes among β-TDT patients adhering to iron chelation therapy by comparing those who developed prediabetes versus those with normal glucose tolerance.Methods: This retrospect...

hrp0098p2-271 | Thyroid | ESPE2024

Thyroid Function Changes During Growth Hormone Therapy in Pediatric Patients: A Review and Comparison with Recent Data

Alaaraj Nada , Soliman Ashraf , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Elsayed Nagwa , Sabt Amal

Introduction: Growth hormone therapy is a cornerstone treatment for children with GHD and ISS. Its impact on the hypothalamic-pituitary-thyroid axis, however, has been a subject of ongoing research.Review of Literature:Early Observations (1992-2005): Pirazzoli et al. (1992) and Tang et al. (1997) were among the first to document changes in thyroid function due to ...

hrp0098p2-272 | Thyroid | ESPE2024

Thyroid function during GH therapy in children with GHD versus those with ISS

Alaaraj Nada , Soliman Ashraf , Alyafei Fawzia , Hamed Noor , Ahmed Shayma , Elsayed Nagwa , Bedair Abdelrahman

Introduction: Hypothyroidism in children leads to growth retardation. However, there is some evidence that recombinant human growth hormone (rhGH) therapy could suppress thyroid function. The actual incidence is controversial, however, with some studies showing a rare and others a high occurrence.Aim and Methods: This study examines the effects of Growth Hormone (GH) therapy on thyroid function, specifically focusing on ...

hrp0098p2-349 | Late Breaking | ESPE2024

Correlation of Pituitary Volume/Size/Height with Clinical Factors in Growth Hormone Deficiency Patients: A Comprehensive Review

Alyafei Fawzia , Soliman Ashraf , Alaaraj Nada , Hamed Noor , Ahmed Shayma , AlHemedi Noora , Elawwa Ahmed

This comprehensive literature review identified studies reporting MRI findings related to pituitary volume in children with GHD. Studies were selected for their relevance to clinical correlations involving short stature, GH peak levels, IGF-1 levels, and therapy response.Results: The 30 studies reviewed highlight significant structural abnormalities in the pituitary gland of children GHD. Key findings include anterior pituitary hypoplasi...

hrp0098p3-83 | Fat, Metabolism and Obesity | ESPE2024

The Relation between Obesity and Thyroid Function in Children and Adolescents

Hamed Noor , Soliman Ashraf , Sabt Amal , Alaaraj Nada , Ahmed Shayma , Alyafei Fawzia

Introduction: The prevalence of obesity in children and adolescents is increasing globally, prompting investigations into its effects on various health parameters, including thyroid function.Aim of the Review: To elucidate the relationship between obesity and thyroid function in the pediatric population through a review of recent studies.Review Results: Analysis of studies involvin...

hrp0098p3-125 | GH and IGFs | ESPE2024

Impact of Sex Steroid Priming on Growth Hormone Stimulation in Children with Short Stature: A Comparative Study"

Alyafei Fawzia , Hamed Noor , Alaaraj Nada , Elsayed Nagwa , Qusad Mohamed , Soliman Ashraf

Introduction: Growth hormone (GH) deficiency in children with short stature poses significant diagnostic and therapeutic challenges. Sex steroid priming before GH stimulation tests (GHST) is a strategy employed to enhance the diagnostic accuracy for GH deficiency. However, the efficacy and impact of this approach remain subjects of debate.Aim: This study aim ed to evaluate the effects of sex steroid priming on various gr...