hrp0097p1-343 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Facilitating Transition of Care Into Adulthood in Brain Cancer Survivors With Acquired Pediatric Growth Hormone Deficiency: Insights From an Advisory Board

Alter Craig , Boguszewski Margaret , Clemmons David , Dobri Georgiana , Geffner Mitchell , Kelepouris Nicky , Miller Bradley , Oh Rich , Shea Heidi , Yuen

Kevin

Childhood cancer survivors (CCS), particularly brain cancer survivors, are at risk of developing growth hormone deficiency (GHD) due to hypothalamic-pituitary damage from direct tumor mass effects or treatment. Optimization of testing, long-term treatment, and monitoring during care transition from pediatric to adult endocrinology providers remain challenging. A group of endocrinology experts convened to discuss these challenges, the risks and benefits of GH therapy in CCS wit...

hrp0097p1-554 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The Evaluation of Cranial Magnetic Resonance Images of Rapidly Progressive Early Puberty Cases

Kilinç Uğurlu Aylin , Özdem&idot;r Gökçe Ayse , Çakir Gündoğan Seçil , Seçil EkşİOğlu Ayşe , Boyraz

Mehmet

Purpose: We aimed to determine the frequency and distribution of intracranial pathologies in patients over 8 years of age by evaluating MRI images of patients diagnosed with early puberty-rapidly progressive.Materials and Methods: The study comprised 118 female patients diagnosed with precocious puberty (PP) and rapidly progressive early puberty (RPEP). The onset of puberty in girls before the age of 8 years is defined a...

hrp0097lb6 | Late Breaking | ESPE2023

A concomitant increase in thinness and weight excess in Brazilian schoolchildren: evaluation from 2010 to 2022

M de Jesus Luciana , M Pinto Renata , B D de Sousa Mariana , P de Oliveira Nayara , de S Gomes Laís

Introduction: The Body Mass Index (BMI) is an essential indicator for the nutritional assessment of children and reflects the exposure to health conditions that are harmful to the development of this population.Objective: To analyze the temporal trends of the BMI of Brazilian children aged 5-10 between 2010 and 2022.Patients and methods: Descriptive ecological study. Data obtained ...

hrp0097lb14 | Late Breaking | ESPE2023

Prevalence and risk factors of bone problems in children with supratentorial midline Low Grade Glioma.

van Roessel IMAA , Gorter JE , Bakker B , van den Heuvel - Eibrink MM , Lequin MH , van der Lugt J , Meijer L , Schouten - van Meeteren AYN , van Santen

HM

Introduction: Children with cancer are at increased risk of endocrine complications, especially children with a brain tumor. One of these late effects includes bone disorders (ranging from low bone mineral density (BMD) to osteoporosis). Children with a suprasellar Low Grade Glioma (LGG) may be especially at risk for bone problems due to exposure to multiple treatment modalities, hypothalamic dysfunction and/or decreased mobility in combination with vision los...

hrp0097lb19 | Late Breaking | ESPE2023

Identification of a novel homozygous mutation in LEPR gene associated with severe early-onset pediatric obesity in two sisters from Central Brazil

Machado Pinto Renata , P Pinto Irene , G Rodovalho Ricardo , de O Silva Lorena , VC Fukushima Lorraine , S Moreira Vanessa , S B de Souza Cristiane

Introduction: Early-onset severe obesity (before five years of age) without intellectual deficit, dysmorphisms, or malformations raises the hypothesis of monogenic obesity. The leptin receptor (Lepr) pathway is essential for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans.Objective: To report the clinical ...

hrp0097p2-254 | Late Breaking | ESPE2023

Decrease in the percentage of eutrophic adolescents in Brazil, temporal evaluation from 2010 to 2022.

M de Jesus Luciana , B D de Sousa Mariana , P de Oliveira Nayara , de S Gomes Laís , M Pinto Renata

Introduction: Adequate nutritional status of adolescents is essential for their healthy development, with health repercussions in both short-term and adult life.Objective: To analyze the temporal trends of the BMI of Brazilian adolescents (10 to 19 years old) between 2010 and 2022.Patients and methods: Descriptive ecological study. Data obtained from e-SUS Primary Care. The BMI cat...

hrp0097p2-264 | Late Breaking | ESPE2023

Improvement in the nutritional status of Brazilian children under five years of age, evaluation from 2010 to 2022.

M Pinto Renata , M de Jesus Luciana , B D de Sousa Mariana , P de Oliveira Nayara , de S Gomes Laís

Introduction: The good nutritional status of children in the first years of life is essential for their healthy growth and development. Evaluating the repercussions of nutritional status is fundamental since nutrition can influence both short-term and adult life.Objective: To analyze the temporal trends of the BMI of Brazilian children aged 0 to 5 between 2010 and 2022.Patients and methods:...

hrp0098fc3.6 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Adolescent Acne: Association to Sex, Age, Pubertal Stage and Circulating Concentrations of Testosterone and DHT

E. Jakobsen Nanna , A. Holmboe Stine , Holm Petersen Jørgen , Aksglaede Lise , P. Hagen Casper , S. Busch Alexander , Holm Johannsen Trine , Frederiksen Hanne , Juul Anders

Background: Presence of current acne is well described in adolescents and adults with altered sex steroid levels, e.g., in polycystic ovarian syndrome, androgen producing tumors and misuse of anabolic androgenic substances. However, less is known about the impact of physiological concentrations of testosterone and dihydrotestosterone (DHT) quantified by gold standard LC-MS/MS methodologies on the development of acne in healthy adolescent boys and girls.<p ...

hrp0098fc9.1 | Sex Endocrinology and Gonads | ESPE2024

A tiered approach to exome sequencing analysis in early-onset Primary Ovarian Insufficiency

McGlacken-Byrne Sinead , P Suntharalingham Jenifer , Ishida Miho , Buonocore Federica , del Valle Ignacio , Cameron-Pimblett Antoinette , Genomics UCL , T Dattani Mehul , C Achermann John , S Conway Gerard

Background: Sequencing of Primary Ovarian Insufficiency (POI) cohorts have identified variants in >100 “POI genes” in up to 50% of women. Establishing pathogenicity of these variants is challenging. Whether early-onset POI (EO-POI; adolescent-onset) has a unique genetic profile remains unknown.Methods: We performed exome sequencing (Nonacus) in an EO-POI cohort (sporadic and familial) and unaffected family...

hrp0098t19 | Top 20 Posters | ESPE2024

Ultrasonographic Evaluation of Ovarian and Uterine Morphology in Minipuberty and Associations with Reproductive Hormones: A COPANA Cohort Study of 302 infant girls.

Bistrup Fischer Margit , Mola Gylli , Scheel Lone , Bak Wraae Katrine , Lilleøre Rom Ane , Frederiksen Hanne , Sundberg Karin , Kristine Hegaard Hanne , Juul Anders , P Hagen Casper

Background: Minipuberty is considered an essential period for early diagnosis of endocrine disorders and reproductive organ maturation. While the complex dynamics of female reproductive hormones during minipuberty was recently described, detailed evaluation of ovarian and uterine morphology in relation to circulating levels of reproductive hormones remains to be elucidated.Aim: Report normative values of ovarian and uter...